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Autophagy regulates long-term cross-presentation by murine dendritic cells.
Ho NI, Camps MGM, Verdoes M, Münz C, Ossendorp F. Ho NI, et al. Among authors: munz c. Eur J Immunol. 2021 Apr;51(4):835-847. doi: 10.1002/eji.202048961. Epub 2021 Feb 10. Eur J Immunol. 2021. PMID: 33349928 Free PMC article.
In the current study, we investigated the role of autophagy in long-term antigen presentation. We show that the autophagy machinery has a negative impact on storage of antigen in DCs. ...Our results indicate that autophagosomes disrupt antigen storage in DCs and thereby re …
In the current study, we investigated the role of autophagy in long-term antigen presentation. We show that the autophagy machinery h …
Poorly cytotoxic terminally differentiated CD56negCD16pos NK cells accumulate in Kenyan children with Burkitt lymphomas.
Forconi CS, Cosgrove CP, Saikumar-Lakshmi P, Nixon CE, Foley J, Ong'echa JM, Otieno JA, Alter G, Münz C, Moormann AM. Forconi CS, et al. Among authors: munz c. Blood Adv. 2018 May 22;2(10):1101-1114. doi: 10.1182/bloodadvances.2017015404. Blood Adv. 2018. PMID: 29764843 Free PMC article.
Of note, the accumulation of poorly cytotoxic CD56(neg)CD16(pos) NK cells resolved in long-term eBL survivors. Our study demonstrates impaired NK cell-mediated immunosurveillance in eBL patients but with the potential to restore a protective NK cell repertoire after cancer …
Of note, the accumulation of poorly cytotoxic CD56(neg)CD16(pos) NK cells resolved in long-term eBL survivors. Our study demonstrates …
Regulatory T Cells in Endemic Burkitt Lymphoma Patients Are Associated with Poor Outcomes: A Prospective, Longitudinal Study.
Parsons E, Otieno JA, Ong'echa JM, Nixon CE, Vulule J, Münz C, Stewart VA, Moormann AM. Parsons E, et al. Among authors: munz c. PLoS One. 2016 Dec 29;11(12):e0167841. doi: 10.1371/journal.pone.0167841. eCollection 2016. PLoS One. 2016. PMID: 28033393 Free PMC article.
CD8+ T cell PD-1 expression was elevated in all eBL patients at time of diagnosis, but relapse patients tended to have persistently high PD-1 expression compared to long-term survivors. Non-survivors produced more CD4+ T-cell IL-10 in response to both Epstein-Barr Nuclear …
CD8+ T cell PD-1 expression was elevated in all eBL patients at time of diagnosis, but relapse patients tended to have persistently high PD- …
Both mature KIR+ and immature KIR- NK cells control pediatric acute B-cell precursor leukemia in NOD.Cg-Prkdcscid IL2rgtmWjl/Sz mice.
Kübler A, Woiterski J, Witte KE, Bühring HJ, Hartwig UF, Ebinger M, Oevermann L, Mezger M, Herr W, Lang P, Handgretinger R, Münz C, André MC. Kübler A, et al. Among authors: munz c. Blood. 2014 Dec 18;124(26):3914-23. doi: 10.1182/blood-2014-05-572743. Epub 2014 Oct 30. Blood. 2014. PMID: 25359989 Free article.
Notably, both adoptively transferred mature KIR(+) NK cells and immature KIR(-) NK cells arising early posttransplantation in humanized NSG mice exerted substantial antileukemic activity. Low-dose and long-term treatment of humanized NSG mice with the DNA-demethylating age …
Notably, both adoptively transferred mature KIR(+) NK cells and immature KIR(-) NK cells arising early posttransplantation in humanized NSG …
Rituximab induces sustained reduction of pathogenic B cells in patients with peripheral nervous system autoimmunity.
Maurer MA, Rakocevic G, Leung CS, Quast I, Lukačišin M, Goebels N, Münz C, Wardemann H, Dalakas M, Lünemann JD. Maurer MA, et al. Among authors: munz c. J Clin Invest. 2012 Apr;122(4):1393-402. doi: 10.1172/JCI58743. Epub 2012 Mar 19. J Clin Invest. 2012. PMID: 22426210 Free PMC article.
The B cell-depleting IgG1 monoclonal antibody rituximab can persistently suppress disease progression in some patients with autoimmune diseases. However, the mechanism underlying these long-term beneficial effects has remained unclear. Here, we evaluated Ig gene usage in p …
The B cell-depleting IgG1 monoclonal antibody rituximab can persistently suppress disease progression in some patients with autoimmune disea …