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The clinical impact of serious respiratory disease in children under the age of two years during the 2021-2022 bronchiolitis season in England, Scotland and Ireland.
Williams TC, Marlow R, Hardelid P, Lyttle MD, Lewis KM, Mpamhanga CD, Cunningham S, Roland D. Williams TC, et al. Among authors: lyttle md. J Infect Dis. 2023 Dec 2:jiad551. doi: 10.1093/infdis/jiad551. Online ahead of print. J Infect Dis. 2023. PMID: 38041864
Risk factors for admission and escalation of care included prematurity and congenital heart disease, but most admissions were for previously healthy term-born children. Of those aged 0-11 months who were admitted and tested for RSV, 1,907/3,912 (48.7%) tested positive. ... …
Risk factors for admission and escalation of care included prematurity and congenital heart disease, but most admissions were for previously …
Delineating COVID-19 subgroups using routine clinical data identifies distinct in-hospital outcomes.
Rangelov B, Young A, Lilaonitkul W, Aslani S, Taylor P, Guðmundsson E, Yang Q, Hu Y, Hurst JR, Hawkes DJ, Jacob J; Тhe NCCID Collaborative. Rangelov B, et al. Sci Rep. 2023 Jun 20;13(1):9986. doi: 10.1038/s41598-023-32469-9. Sci Rep. 2023. PMID: 37339958 Free PMC article.
We adapted an unsupervised data-driven model-SuStaIn, to be utilised for short-term infectious disease like COVID-19, based on 11 commonly recorded clinical measures. ...
We adapted an unsupervised data-driven model-SuStaIn, to be utilised for short-term infectious disease like COVID-19, based on 11 com …
Factors related to adverse long-term outcomes after mild traumatic brain injury in children: a scoping review.
Ijaz S, Scott L, Dawson S, Wilson R, Jackson J, Birnie K, Redaniel MT, Savović J, Wright I, Lyttle MD, Mytton J. Ijaz S, et al. Among authors: lyttle md. Arch Dis Child. 2023 Jun;108(6):492-497. doi: 10.1136/archdischild-2022-325202. Epub 2023 Mar 31. Arch Dis Child. 2023. PMID: 37001968 Free PMC article. Review.
OBJECTIVE: To identify demographic, premorbid and injury-related factors, or biomarkers associated with long-term (3 months) adverse outcomes in children after mild traumatic brain injury (mTBI). ...RESULTS: Seventy-three publications were included, reporting 12 long-te …
OBJECTIVE: To identify demographic, premorbid and injury-related factors, or biomarkers associated with long-term (3 months) adverse …
Incidence of traumatic brain injuries in head-injured children with seizures.
Borland ML, Dalziel SR, Phillips N, Dalton S, Lyttle MD, Bressan S, Oakley E, Kochar A, Furyk J, Cheek JA, Neutze J, Eapen N, Hearps SJ, Rausa VC, Babl FE; Paediatric Research in Emergency Departments International Collaborative (PREDICT) group. Borland ML, et al. Among authors: lyttle md. Emerg Med Australas. 2023 Apr;35(2):289-296. doi: 10.1111/1742-6723.14112. Epub 2022 Nov 2. Emerg Med Australas. 2023. PMID: 36323396 Free PMC article.
OBJECTIVE: Incidence and short-term outcomes of clinically important traumatic brain injury (ciTBI) in head-injured children presenting to ED with post-traumatic seizure (PTS) is not described in current literature. ...
OBJECTIVE: Incidence and short-term outcomes of clinically important traumatic brain injury (ciTBI) in head-injured children presenti …
Pain management in children and young adults with minor injury in emergency departments in the UK and Ireland: a PERUKI service evaluation.
Hartshorn S, Durnin S, Lyttle MD, Barrett M; PERUKI. Hartshorn S, et al. Among authors: lyttle md. BMJ Paediatr Open. 2022 Mar;6(1):e001273. doi: 10.1136/bmjpo-2021-001273. BMJ Paediatr Open. 2022. PMID: 36053599 Free PMC article.
BACKGROUND: Management of acute pain should commence at the earliest opportunity, as it has many short-term and long-term consequences. A research priority of Paediatric Emergency Research in the UK and Ireland (PERUKI) was to examine paediatric pain practices. ...
BACKGROUND: Management of acute pain should commence at the earliest opportunity, as it has many short-term and long-term cons …
Psychological distress during the acceleration phase of the COVID-19 pandemic: a survey of doctors practising in emergency medicine, anaesthesia and intensive care medicine in the UK and Ireland.
Roberts T, Daniels J, Hulme W, Hirst R, Horner D, Lyttle MD, Samuel K, Graham B, Reynard C, Barrett M, Foley J, Cronin J, Umana E, Vinagre J, Carlton E; collaborators of TERN, RAFT, PERUKI, ITERN, TRIC, and SATARN. Roberts T, et al. Among authors: lyttle md. Emerg Med J. 2021 Jun;38(6):450-459. doi: 10.1136/emermed-2020-210438. Epub 2021 Apr 8. Emerg Med J. 2021. PMID: 33832926
Findings from this study should inform strategies to optimise preparedness and explore modifiable factors associated with increased psychological distress in the short and long term. TRIAL REGISTRATION NUMBER: ISRCTN10666798....
Findings from this study should inform strategies to optimise preparedness and explore modifiable factors associated with increased psycholo …
Need for recovery amongst emergency physicians in the UK and Ireland: a cross-sectional survey.
Cottey L, Roberts T, Graham B, Horner D, Stevens KN, Enki D, Lyttle MD, Latour J; Trainee Emergency Research Network (TERN) and Paediatric Emergency Research in the UK and Ireland (PERUKI). Cottey L, et al. Among authors: lyttle md. BMJ Open. 2020 Nov 2;10(11):e041485. doi: 10.1136/bmjopen-2020-041485. BMJ Open. 2020. PMID: 33139301 Free PMC article.
Groups including male physicians, consultants, general practitioners (GPs) within the ED, those working in paediatric EDs and those with no long-term health condition or disability had a lower NFR Score. After adjusting for these characteristics, the NFR Score increased by …
Groups including male physicians, consultants, general practitioners (GPs) within the ED, those working in paediatric EDs and those with no …
Neonatal head injuries: A prospective Paediatric Research in Emergency Departments International Collaborative cohort study.
Eapen N, Borland ML, Phillips N, Kochar A, Dalton S, Cheek JA, Gilhotra Y, Neutze J, Lyttle MD, Donath S, Crowe L, Dalziel SR, Oakley E, Williams A, Hearps S, Bressan S, Babl FE. Eapen N, et al. Among authors: lyttle md. J Paediatr Child Health. 2020 May;56(5):764-769. doi: 10.1111/jpc.14736. Epub 2019 Dec 23. J Paediatr Child Health. 2020. PMID: 31868278
AIM: To characterise the causes, clinical characteristics and short-term outcomes of neonates who presented to paediatric emergency departments with a head injury. ...CONCLUSIONS: Neonatal head injuries are rare with a mostly benign short-term outcome and are approp …
AIM: To characterise the causes, clinical characteristics and short-term outcomes of neonates who presented to paediatric emergency d …
Parents' prioritised outcomes for trials investigating treatments for paediatric severe infection: a qualitative synthesis.
Woolfall K, O'Hara C, Deja E, Canter R, Khan I, Mouncey P, Carter A, Jones N, Watkins J, Lyttle MD, Tume L, Agbeko R, Tibby SM, Pappachan J, Thorburn K, Rowan KM, Peters MJ, Inwald D; PERUKI (Paediatric Emergency Research in the UK and Ireland) and PICS (Paediatric Intensive Care Society). Woolfall K, et al. Among authors: lyttle md. Arch Dis Child. 2019 Nov;104(11):1077-1082. doi: 10.1136/archdischild-2019-316807. Epub 2019 Jun 7. Arch Dis Child. 2019. PMID: 31175125 Free PMC article.
Fever study: n=44 parents, 33 mothers, 11 fathers, 7 were bereaved. RESULTS: In addition to survival, parents prioritised short-term outcomes including: organ and physiological functioning (eg, heart rate, breathing rate and temperature); their child looking and/or behavin …
Fever study: n=44 parents, 33 mothers, 11 fathers, 7 were bereaved. RESULTS: In addition to survival, parents prioritised short-term …
A prospective observational study to assess the diagnostic accuracy of clinical decision rules for children presenting to emergency departments after head injuries (protocol): the Australasian Paediatric Head Injury Rules Study (APHIRST).
Babl FE, Lyttle MD, Bressan S, Borland M, Phillips N, Kochar A, Dalziel SR, Dalton S, Cheek JA, Furyk J, Gilhotra Y, Neutze J, Ward B, Donath S, Jachno K, Crowe L, Williams A, Oakley E; PREDICT research network. Babl FE, et al. Among authors: lyttle md. BMC Pediatr. 2014 Jun 13;14:148. doi: 10.1186/1471-2431-14-148. BMC Pediatr. 2014. PMID: 24927811 Free PMC article.
Failure to identify a clinically significant intracranial injury in a timely fashion may result in long term neurodisability and death. Whilst cranial computed tomography (CT) provides rapid and definitive identification of intracranial injuries, it is resource intensive a …
Failure to identify a clinically significant intracranial injury in a timely fashion may result in long term neurodisability and deat …