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Principles of transcriptional regulation and evolution of the metabolic system in E. coli.
Seshasayee AS, Fraser GM, Babu MM, Luscombe NM. Seshasayee AS, et al. Among authors: luscombe nm. Genome Res. 2009 Jan;19(1):79-91. doi: 10.1101/gr.079715.108. Epub 2008 Oct 3. Genome Res. 2009. PMID: 18836036 Free PMC article.
Organisms must adapt to make optimal use of the metabolic system in response to environmental changes. In the long-term, this involves evolution of the genomic repertoire of enzymes; in the short-term, transcriptional control ensures that appropriate enzymes are exp …
Organisms must adapt to make optimal use of the metabolic system in response to environmental changes. In the long-term, this involve …
Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility.
Pearson MM, Sebaihia M, Churcher C, Quail MA, Seshasayee AS, Luscombe NM, Abdellah Z, Arrosmith C, Atkin B, Chillingworth T, Hauser H, Jagels K, Moule S, Mungall K, Norbertczak H, Rabbinowitsch E, Walker D, Whithead S, Thomson NR, Rather PN, Parkhill J, Mobley HL. Pearson MM, et al. Among authors: luscombe nm. J Bacteriol. 2008 Jun;190(11):4027-37. doi: 10.1128/JB.01981-07. Epub 2008 Mar 28. J Bacteriol. 2008. PMID: 18375554 Free PMC article.
The gram-negative enteric bacterium Proteus mirabilis is a frequent cause of urinary tract infections in individuals with long-term indwelling catheters or with complicated urinary tracts (e.g., due to spinal cord injury or anatomic abnormality). ...Here we report the comp …
The gram-negative enteric bacterium Proteus mirabilis is a frequent cause of urinary tract infections in individuals with long-term i …
Protein family and fold occurrence in genomes: power-law behaviour and evolutionary model.
Qian J, Luscombe NM, Gerstein M. Qian J, et al. Among authors: luscombe nm. J Mol Biol. 2001 Nov 2;313(4):673-81. doi: 10.1006/jmbi.2001.5079. J Mol Biol. 2001. PMID: 11697896
In the model, genomes evolve through two basic operations: (i) duplication of existing genes; (ii) net flow of new genes. The flow term is closely related to the exponent b and can accommodate considerable gene loss; however, we demonstrate that the observed data is reprod …
In the model, genomes evolve through two basic operations: (i) duplication of existing genes; (ii) net flow of new genes. The flow term …
Interrelating different types of genomic data, from proteome to secretome: 'oming in on function.
Greenbaum D, Luscombe NM, Jansen R, Qian J, Gerstein M. Greenbaum D, et al. Among authors: luscombe nm. Genome Res. 2001 Sep;11(9):1463-8. doi: 10.1101/gr.207401. Genome Res. 2001. PMID: 11544189 Free article.
Thus, a key approach in genomic research is to divide the cellular contents into distinct sub-populations, which are often given an "-omic" term. For example, the proteome is the full complement of proteins encoded by the genome, and the secretome is the part of it secrete …
Thus, a key approach in genomic research is to divide the cellular contents into distinct sub-populations, which are often given an "-omic" …