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The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.
Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. Willsey AJ, et al. Among authors: lowenstein dh. Cell. 2018 Jul 26;174(3):505-520. doi: 10.1016/j.cell.2018.06.016. Cell. 2018. PMID: 30053424 Free PMC article. Review.
These efforts will include a team of geneticists, structural biologists, neurobiologists, systems biologists, and clinicians, leveraging a wide array of experimental approaches and creating a collaborative infrastructure necessary for long-term investigation. This initiati …
These efforts will include a team of geneticists, structural biologists, neurobiologists, systems biologists, and clinicians, leveraging a w …
A definition and classification of status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus.
Trinka E, Cock H, Hesdorffer D, Rossetti AO, Scheffer IE, Shinnar S, Shorvon S, Lowenstein DH. Trinka E, et al. Among authors: lowenstein dh. Epilepsia. 2015 Oct;56(10):1515-23. doi: 10.1111/epi.13121. Epub 2015 Sep 4. Epilepsia. 2015. PMID: 26336950 Free article. Review.
The proposed new definition of SE is as follows: Status epilepticus is a condition resulting either from the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms, which lead to abnormally, prolonged seizures (after time point t1 ). It …
The proposed new definition of SE is as follows: Status epilepticus is a condition resulting either from the failure of the mechanisms respo …
Posttraumatic epilepsy: a major problem in desperate need of major advances.
Garga N, Lowenstein DH. Garga N, et al. Among authors: lowenstein dh. Epilepsy Curr. 2006 Jan-Feb;6(1):1-5. doi: 10.1111/j.1535-7511.2005.00083.x. Epilepsy Curr. 2006. PMID: 16477313 Free PMC article.
Laboratory studies, which have relied primarily on the fluid-percussion model, have documented long-term hyperexcitability associated with TBI, and recent studies are shedding light on the structural and electrophysiological abnormalities that may underlie epileptogenesis …
Laboratory studies, which have relied primarily on the fluid-percussion model, have documented long-term hyperexcitability associated …
The Academy at Harvard Medical School: nurturing teaching and stimulating innovation.
Thibault GE, Neill JM, Lowenstein DH. Thibault GE, et al. Among authors: lowenstein dh. Acad Med. 2003 Jul;78(7):673-81. doi: 10.1097/00001888-200307000-00005. Acad Med. 2003. PMID: 12857684
The authors describe the academy's membership criteria, structure, governance, activities, institutional impact, and plans for long-term evaluation, and indicate challenges the academy will face in the future....
The authors describe the academy's membership criteria, structure, governance, activities, institutional impact, and plans for long-term …
The prehospital treatment of status epilepticus (PHTSE) study: design and methodology.
Lowenstein DH, Alldredge BK, Allen F, Neuhaus J, Corry M, Gottwald M, O'Neil N, Ulrich S, Isaacs SM, Gelb A. Lowenstein DH, et al. Control Clin Trials. 2001 Jun;22(3):290-309. doi: 10.1016/s0197-2456(01)00120-9. Control Clin Trials. 2001. PMID: 11384791 Clinical Trial.
The Prehospital Treatment of Status Epilepticus (PHTSE) study is a prospective, randomized, double-blind, placebo-controlled study designed to address the following aims: (1) to determine whether administration of benzodiazepines by paramedics is an effective and safe means of tr …
The Prehospital Treatment of Status Epilepticus (PHTSE) study is a prospective, randomized, double-blind, placebo-controlled study designed …
Recent advances related to basic mechanisms of epileptogenesis.
Lowenstein DH. Lowenstein DH. Epilepsy Res Suppl. 1996;11:45-60. Epilepsy Res Suppl. 1996. PMID: 9294727 Review.
A variety of clinical observations suggest that certain forms of epilepsy are due to long-term, progressive changes in neural networks that eventually provoke spontaneous and recurring seizures. ...
A variety of clinical observations suggest that certain forms of epilepsy are due to long-term, progressive changes in neural network …
The stress protein response and its potential relationship to prolonged seizure activity.
Lowenstein DH. Lowenstein DH. Clin Neuropharmacol. 1995 Apr;18(2):148-58. doi: 10.1097/00002826-199504000-00006. Clin Neuropharmacol. 1995. PMID: 8635174 Review.
Given the growing numbers of genes that appear to be modulated by seizures, it appears that seizures initiate a tremendous cascade of changes in gene expression over both the short and the long term. In this article, I discuss two main classes of gene products that are mod …
Given the growing numbers of genes that appear to be modulated by seizures, it appears that seizures initiate a tremendous cascade of change …
Prognostic factors of pentobarbital therapy for refractory generalized status epilepticus.
Yaffe K, Lowenstein DH. Yaffe K, et al. Among authors: lowenstein dh. Neurology. 1993 May;43(5):895-900. doi: 10.1212/wnl.43.5.895. Neurology. 1993. PMID: 8492944

Survival was associated with a history of epilepsy, absence of multiorgan failure before or during PBC, age < 40 years, and absence of hypotension requiring vasopressors during PBC. Long-term follow-up in seven of eight survivors (mean, 2.9 years; range, 1 to 5 years) s

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Survival was associated with a history of epilepsy, absence of multiorgan failure before or during PBC, age < 40 years, and absence of hy

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Status epilepticus at an urban public hospital in the 1980s.
Lowenstein DH, Alldredge BK. Lowenstein DH, et al. Neurology. 1993 Mar;43(3 Pt 1):483-8. doi: 10.1212/wnl.43.3_part_1.483. Neurology. 1993. PMID: 8450988
The review was designed to determine whether the etiologies of SE at our hospital have changed over the last two decades, and to investigate the relationships between etiology, response to anticonvulsant therapy, and short-term clinical outcome. Of 154 patients reviewed, t …
The review was designed to determine whether the etiologies of SE at our hospital have changed over the last two decades, and to investigate …
Differential expression of K+ channel mRNAs in the rat brain and down-regulation in the hippocampus following seizures.
Tsaur ML, Sheng M, Lowenstein DH, Jan YN, Jan LY. Tsaur ML, et al. Among authors: lowenstein dh. Neuron. 1992 Jun;8(6):1055-67. doi: 10.1016/0896-6273(92)90127-y. Neuron. 1992. PMID: 1610565
In addition, seizure activity caused a reduction of Kv1.2 and Kv4.2 mRNAs in the dentate granule cells of the hippocampus, raising the possibility that K+ channel gene regulation may play a role in long-term neuronal plasticity....
In addition, seizure activity caused a reduction of Kv1.2 and Kv4.2 mRNAs in the dentate granule cells of the hippocampus, raising the possi …
13 results