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Modeling of copy number variability in Pichia pastoris.
Lu AE, Maloney AJ, Dalvie NC, Brady JR, Love KR, Love JC, Braatz RD. Lu AE, et al. Among authors: love kr. Biotechnol Bioeng. 2021 May;118(5):1832-1839. doi: 10.1002/bit.27698. Epub 2021 Feb 19. Biotechnol Bioeng. 2021. PMID: 33527350
Development of continuous biopharmaceutical manufacturing processes is an area of active research. This study considers the long-term transgene copy number stability of Pichia pastoris in continuous bioreactors. ...
Development of continuous biopharmaceutical manufacturing processes is an area of active research. This study considers the long-term …
Rapid Developability Assessments to Formulate Recombinant Protein Antigens as Stable, Low-Cost, Multi-Dose Vaccine Candidates: Case-Study With Non-Replicating Rotavirus (NRRV) Vaccine Antigens.
Sawant N, Kaur K, Holland DA, Hickey JM, Agarwal S, Brady JR, Dalvie NC, Tracey MK, Velez-Suberbie ML, Morris SA, Jacob SI, Bracewell DG, Mukhopadhyay TK, Love KR, Love JC, Joshi SB, Volkin DB. Sawant N, et al. Among authors: love kr. J Pharm Sci. 2021 Mar;110(3):1042-1053. doi: 10.1016/j.xphs.2020.11.039. Epub 2020 Dec 5. J Pharm Sci. 2021. PMID: 33285182 Free PMC article.
These case-study results with P[8] and P[4] NRRV variants are discussed in terms of using this vaccine formulation developability workflow to better inform and optimize formulation design with a wide variety of recombinant protein antigens, with the long-term goal of rapid …
These case-study results with P[8] and P[4] NRRV variants are discussed in terms of using this vaccine formulation developability workflow t …
The yeast stands alone: the future of protein biologic production.
Love KR, Dalvie NC, Love JC. Love KR, et al. Curr Opin Biotechnol. 2018 Oct;53:50-58. doi: 10.1016/j.copbio.2017.12.010. Epub 2017 Dec 22. Curr Opin Biotechnol. 2018. PMID: 29277062 Review.
Specifically, Pichia pastoris is becoming a widely accepted yeast for biopharmaceutical manufacturing in much of the world owing to a clean secreted product and the rapidly expanding understanding of its cell biology as a host organism. We advocate for a near term partners …
Specifically, Pichia pastoris is becoming a widely accepted yeast for biopharmaceutical manufacturing in much of the world owing to a clean …
Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots.
Bonasio R, Carman CV, Kim E, Sage PT, Love KR, Mempel TR, Springer TA, von Andrian UH. Bonasio R, et al. Among authors: love kr. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14753-8. doi: 10.1073/pnas.0705201104. Epub 2007 Sep 4. Proc Natl Acad Sci U S A. 2007. PMID: 17785425 Free PMC article.
Most approaches to labeling proteins exploit noncovalent interactions, unsuitable to long-term studies, or genetic fusion to naturally occurring fluorescent proteins that often have unsatisfactory optical properties. ...
Most approaches to labeling proteins exploit noncovalent interactions, unsuitable to long-term studies, or genetic fusion to naturall …
OKT3 induction and steroid-free maintenance immunosuppression for treatment of high-risk heart transplant recipients.
Prieto M, Lake KD, Pritzker MR, Jorgensen CR, Arom KV, Love KR, Emery RW. Prieto M, et al. Among authors: love kr. J Heart Lung Transplant. 1991 Nov-Dec;10(6):901-11. J Heart Lung Transplant. 1991. PMID: 1661608
In conclusion, high-risk patients treated with OKT3 and steroid-free maintenance immunosuppression were managed on smaller doses of immunosuppressive drugs in the early postoperative period, and had excellent long-term survival rates. In this group of patients, rejection w …
In conclusion, high-risk patients treated with OKT3 and steroid-free maintenance immunosuppression were managed on smaller doses of immunosu …