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Idiopathic pulmonary arterial hypertension and co-existing lung disease: is this a new phenotype?
Peacock AJ, Ling Y, Johnson MK, Kiely DG, Condliffe R, Elliot CA, Gibbs JSR, Howard LS, Pepke-Zaba J, Sheares KKK, Corris PA, Fisher AJ, Lordan JL, Gaine S, Coghlan JG, Wort SJ, Gatzoulis MA. Peacock AJ, et al. Among authors: lordan jl. Pulm Circ. 2020 Mar 30;10(1):2045894020914851. doi: 10.1177/2045894020914851. eCollection 2020 Jan-Mar. Pulm Circ. 2020. PMID: 32284847 Free PMC article.
This survival was significantly worse in 'IPAH (lung disease) ' even after adjusting for age, gender, smoking history, comorbidities and haemodynamics. 'IPAH (lung disease) ' patients had similar short-term improvement in six-minute walk distance with anti-pulmonary arteri …
This survival was significantly worse in 'IPAH (lung disease) ' even after adjusting for age, gender, smoking history, comorbidities and hae …
Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension. A Double-Blind Placebo-controlled Clinical Trial.
White RJ, Jerjes-Sanchez C, Bohns Meyer GM, Pulido T, Sepulveda P, Wang KY, Grünig E, Hiremath S, Yu Z, Gangcheng Z, Yip WLJ, Zhang S, Khan A, Deng CQ, Grover R, Tapson VF; FREEDOM-EV Investigators. White RJ, et al. Am J Respir Crit Care Med. 2020 Mar 15;201(6):707-717. doi: 10.1164/rccm.201908-1640OC. Am J Respir Crit Care Med. 2020. PMID: 31765604 Free PMC article. Clinical Trial.
The primary endpoint was the time to first adjudicated clinical worsening event: death; hospitalization due to worsening PAH; initiation of inhaled or parenteral prostacyclin therapy; disease progression; or unsatisfactory long-term clinical response.Measurements and Main …
The primary endpoint was the time to first adjudicated clinical worsening event: death; hospitalization due to worsening PAH; initiation of …
Long-term effect of azithromycin in bronchiolitis obliterans syndrome.
Gan CT, Ward C, Meachery G, Lordan JL, Fisher AJ, Corris PA. Gan CT, et al. Among authors: lordan jl. BMJ Open Respir Res. 2019 Oct 15;6(1):e000465. doi: 10.1136/bmjresp-2019-000465. eCollection 2019. BMJ Open Respir Res. 2019. PMID: 31673366 Free PMC article. Clinical Trial.
Survival of patients with early BOS was similar to late-onset BOS (log-rank test p=0.74). DISCUSSION: Long-term treatment with azithromycin slows down the progression of BOS, although the effect of TLI may affect the observed attenuation of FEV(1) decline. BOS progression …
Survival of patients with early BOS was similar to late-onset BOS (log-rank test p=0.74). DISCUSSION: Long-term treatment with azithr …
Change in type-2 biomarkers and related cytokines with prednisolone in uncontrolled severe oral corticosteroid dependent asthmatics: an interventional open-label study.
Busby J, Holweg CTJ, Chai A, Bradding P, Cai F, Chaudhuri R, Mansur AH, Lordan JL, Matthews JG, Menzies-Gow A, Niven R, Staton T, Heaney LG. Busby J, et al. Among authors: lordan jl. Thorax. 2019 Aug;74(8):806-809. doi: 10.1136/thoraxjnl-2018-212709. Epub 2019 Apr 2. Thorax. 2019. PMID: 30940770
Following rescue OCS, 1 month is sufficient before using type-2 biomarkers to guide long-term treatment. TRIAL REGISTRATION NUMBER: NCT01948401....
Following rescue OCS, 1 month is sufficient before using type-2 biomarkers to guide long-term treatment. TRIAL REGISTRATION NUMBER: N …
Survival in portopulmonary hypertension: Outcomes of the United Kingdom National Pulmonary Arterial Hypertension Registry.
Sithamparanathan S, Nair A, Thirugnanasothy L, Coghlan JG, Condliffe R, Dimopoulos K, Elliot CA, Fisher AJ, Gaine S, Gibbs JSR, Gatzoulis MA, E Handler C, Howard LS, Johnson M, Kiely DG, Lordan JL, Peacock AJ, Pepke-Zaba J, Schreiber BE, Sheares KKK, Wort SJ, Corris PA; National Pulmonary Hypertension Service Research Collaboration of the United Kingdom and Ireland. Sithamparanathan S, et al. Among authors: lordan jl. J Heart Lung Transplant. 2017 Jul;36(7):770-779. doi: 10.1016/j.healun.2016.12.014. Epub 2016 Dec 31. J Heart Lung Transplant. 2017. PMID: 28190786
BACKGROUND: Portopulmonary hypertension (PoPH) is a rare condition associated with poor survival, and the effect of modern therapies that target pulmonary arterial hypertension (PAH) on long-term outcome is unknown. This study investigated the baseline characteristics and …
BACKGROUND: Portopulmonary hypertension (PoPH) is a rare condition associated with poor survival, and the effect of modern therapies that ta …
Observational study of lung transplant recipients surviving 20 years.
Sithamparanathan S, Thirugnanasothy L, Clark S, Dark JH, Fisher AJ, Gould KF, Hasan A, Lordan JL, Meachery G, Parry G, Corris PA. Sithamparanathan S, et al. Among authors: lordan jl. Respir Med. 2016 Aug;117:103-8. doi: 10.1016/j.rmed.2016.06.008. Epub 2016 Jun 7. Respir Med. 2016. PMID: 27492519 Free article. Clinical Trial.
BACKGROUND: Lung transplant recipients have reduced long-term survival compared with other solid organ recipients. There is a lack of published data on the characteristics of very long term survivors. ...CONCLUSIONS: In our experience, 20-year survivors of lung tran …
BACKGROUND: Lung transplant recipients have reduced long-term survival compared with other solid organ recipients. There is a lack of …
Pregnancy after lung and heart-lung transplantation.
Thakrar MV, Morley K, Lordan JL, Meachery G, Fisher AJ, Parry G, Corris PA. Thakrar MV, et al. Among authors: lordan jl. J Heart Lung Transplant. 2014 Jun;33(6):593-8. doi: 10.1016/j.healun.2014.02.008. Epub 2014 Feb 17. J Heart Lung Transplant. 2014. PMID: 24709268
Six patients have since died, with pregnancy contributing to 1 death. Five pregnancies were unplanned, with only 1 resulting in birth. Six pregnancies ended with spontaneous termination, and 2 were terminated for medical reasons. ...Mean change in Forced expiratory volume …
Six patients have since died, with pregnancy contributing to 1 death. Five pregnancies were unplanned, with only 1 resulting in birth
Non-cystic fibrosis bronchiectasis.
McDonnell MJ, Ward C, Lordan JL, Rutherford RM. McDonnell MJ, et al. Among authors: lordan jl. QJM. 2013 Aug;106(8):709-15. doi: 10.1093/qjmed/hct109. Epub 2013 May 30. QJM. 2013. PMID: 23728208 Review.
The associated burden of disease in terms of increased morbidity, reduced quality of life and the socioeconomic cost of long-term management is significant. Further research is essential to improve our understanding of the development and progression of this disease. ...
The associated burden of disease in terms of increased morbidity, reduced quality of life and the socioeconomic cost of long-term man …
Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: results from the pulmonary hypertension registry of the United Kingdom and Ireland.
Ling Y, Johnson MK, Kiely DG, Condliffe R, Elliot CA, Gibbs JS, Howard LS, Pepke-Zaba J, Sheares KK, Corris PA, Fisher AJ, Lordan JL, Gaine S, Coghlan JG, Wort SJ, Gatzoulis MA, Peacock AJ. Ling Y, et al. Among authors: lordan jl. Am J Respir Crit Care Med. 2012 Oct 15;186(8):790-6. doi: 10.1164/rccm.201203-0383OC. Epub 2012 Jul 12. Am J Respir Crit Care Med. 2012. PMID: 22798320
In comparison with the earlier cohorts, patients diagnosed in 2007-2009 were older, more obese, had lower percent diffusing capacity of carbon monoxide,(,) and more comorbidities, but better survival. Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension …
In comparison with the earlier cohorts, patients diagnosed in 2007-2009 were older, more obese, had lower percent diffusing capacity of carb …
Pulmonary arterial hypertension and lung transplantation.
Lordan JL, Corris PA. Lordan JL, et al. Expert Rev Respir Med. 2011 Jun;5(3):441-54. doi: 10.1586/ers.11.21. Expert Rev Respir Med. 2011. PMID: 21702664 Review.
Recent transplant outcomes for PAH are encouraging, albeit with early postoperative risks, a requirement for long-term surveillance, immunosuppression and transplant immunosuppression-specific morbidity....
Recent transplant outcomes for PAH are encouraging, albeit with early postoperative risks, a requirement for long-term surveillance, …
13 results