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Optimization of polygenic risk scores in BRCA1/2 pathogenic variant heterozygotes in epithelial ovarian cancer.
Flaum N, Bowes J, Smith MJ, Crosbie EJ, Edmondson R, Lophatananon A, Evans DG. Flaum N, et al. Among authors: lophatananon a. Genet Med. 2023 Sep;25(9):100898. doi: 10.1016/j.gim.2023.100898. Epub 2023 May 19. Genet Med. 2023. PMID: 37212253 Free article.
The optimized model (parity, age at menarche, menopause, and first full-term pregnancy) estimated AUC values of 0.872 to 0.876 and 21- to 23-fold increase in OR (BRCA1 heterozygotes) and AUC values of 0.857 to 0.867 and 40- to 41-fold increase (BRCA2 heterozygotes). ...
The optimized model (parity, age at menarche, menopause, and first full-term pregnancy) estimated AUC values of 0.872 to 0.876 and 21 …
Assessing the impact of MRI based diagnostics on pre-treatment disease classification and prognostic model performance in men diagnosed with new prostate cancer from an unscreened population.
Lophatananon A, Byrne MHV, Barrett T, Warren A, Muir K, Dokubo I, Georgiades F, Sheba M, Bibby L, Gnanapragasam VJ. Lophatananon A, et al. BMC Cancer. 2022 Aug 11;22(1):878. doi: 10.1186/s12885-022-09955-w. BMC Cancer. 2022. PMID: 35953766 Free PMC article.
Differences were retrofitted to a population cohort with long-term prostate cancer mortality (PCM) outcomes to simulate impact on model performance. ...Existing risk and prognostic models can continue to be used to counsel men about treatment option until long term …
Differences were retrofitted to a population cohort with long-term prostate cancer mortality (PCM) outcomes to simulate impact on mod …
Using the Movember Foundation's GAP3 cohort to measure the effect of active surveillance on patient-reported urinary and sexual function-a retrospective study in low-risk prostate cancer patients.
Crump RT, Remmers S, Van Hemelrijck M, Helleman J, Nieboer D, Roobol MJ, Venderbos LDF; Movember Foundation’s Global Action Plan Prostate Cancer Active Surveillance (GAP3) consortium. Crump RT, et al. Transl Androl Urol. 2021 Jun;10(6):2719-2727. doi: 10.21037/tau-20-1255. Transl Androl Urol. 2021. PMID: 34295757 Free PMC article.
In the meantime, clinicians and patients should anticipate a potential decline in erectile function and hence consider incorporating the risk of this harm into their discussion about opting for AS and also when deciding on the stringency of follow-up biopsy schedules with long- …
In the meantime, clinicians and patients should anticipate a potential decline in erectile function and hence consider incorporating the ris …
Active surveillance for prostate cancer: a narrative review of clinical guidelines.
Bruinsma SM, Bangma CH, Carroll PR, Leapman MS, Rannikko A, Petrides N, Weerakoon M, Bokhorst LP, Roobol MJ; Movember GAP3 consortium. Bruinsma SM, et al. Nat Rev Urol. 2016 Mar;13(3):151-67. doi: 10.1038/nrurol.2015.313. Epub 2016 Jan 27. Nat Rev Urol. 2016. PMID: 26813955 Review.
To enable truly evidence-based guidelines, further research that combines existing evidence, while also gathering information from more long-term studies is needed....
To enable truly evidence-based guidelines, further research that combines existing evidence, while also gathering information from more long …
A nurse-delivered advice intervention can reduce chronic non-steroidal anti-inflammatory drug use in general practice: a randomized controlled trial.
Jones AC, Coulson L, Muir K, Tolley K, Lophatananon A, Everitt L, Pringle M, Doherty M. Jones AC, et al. Among authors: lophatananon a. Rheumatology (Oxford). 2002 Jan;41(1):14-21. doi: 10.1093/rheumatology/41.1.14. Rheumatology (Oxford). 2002. PMID: 11792874 Clinical Trial.
CONCLUSIONS: Nurse-based intervention can reduce chronic NSAID usage and costs in primary care and would be cost-effective if maintained in the long term. This intervention package would be readily applicable in primary care....
CONCLUSIONS: Nurse-based intervention can reduce chronic NSAID usage and costs in primary care and would be cost-effective if maintained in …