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Metabolic effects of cardiovascular drugs.
Fragasso G, Margonato A, Spoladore R, Lopaschuk GD. Fragasso G, et al. Among authors: lopaschuk gd. Trends Cardiovasc Med. 2019 Apr;29(3):176-187. doi: 10.1016/j.tcm.2018.08.001. Epub 2018 Aug 7. Trends Cardiovasc Med. 2019. PMID: 30122289 Review.
In this context, drugs affecting global and cardiovascular metabolism besides their recognized main mechanism of action may be of special interest, for both potential beneficial and deleterious effects, especially in the long-term period. In all cases, these effects should …
In this context, drugs affecting global and cardiovascular metabolism besides their recognized main mechanism of action may be of special in …
Inhibition of Soluble Epoxide Hydrolase Limits Mitochondrial Damage and Preserves Function Following Ischemic Injury.
Akhnokh MK, Yang FH, Samokhvalov V, Jamieson KL, Cho WJ, Wagg C, Takawale A, Wang X, Lopaschuk GD, Hammock BD, Kassiri Z, Seubert JM. Akhnokh MK, et al. Among authors: lopaschuk gd. Front Pharmacol. 2016 Jun 7;7:133. doi: 10.3389/fphar.2016.00133. eCollection 2016. Front Pharmacol. 2016. PMID: 27375480 Free PMC article.
CONCLUSION: Inhibition or genetic deletion of sEH protects against long-term ischemia by preserving cardiac function and maintaining mitochondrial efficiency....
CONCLUSION: Inhibition or genetic deletion of sEH protects against long-term ischemia by preserving cardiac function and maintaining …
Effect of fatty acids on human bone marrow mesenchymal stem cell energy metabolism and survival.
Fillmore N, Huqi A, Jaswal JS, Mori J, Paulin R, Haromy A, Onay-Besikci A, Ionescu L, Thébaud B, Michelakis E, Lopaschuk GD. Fillmore N, et al. Among authors: lopaschuk gd. PLoS One. 2015 Mar 13;10(3):e0120257. doi: 10.1371/journal.pone.0120257. eCollection 2015. PLoS One. 2015. PMID: 25768019 Free PMC article.
These results also suggest that saturated fatty acids may be involved in the long-term impairment of BMMSC survival in vivo....
These results also suggest that saturated fatty acids may be involved in the long-term impairment of BMMSC survival in vivo....
FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.
Piao L, Sidhu VK, Fang YH, Ryan JJ, Parikh KS, Hong Z, Toth PT, Morrow E, Kutty S, Lopaschuk GD, Archer SL. Piao L, et al. Among authors: lopaschuk gd. J Mol Med (Berl). 2013 Mar;91(3):333-46. doi: 10.1007/s00109-012-0982-0. Epub 2012 Dec 18. J Mol Med (Berl). 2013. PMID: 23247844 Free PMC article.
The stimulus for PDK upregulation, its isoform specificity, and the long-term effects of PDK inhibition are unknown. We hypothesize that FOXO1-mediated PDK4 upregulation causes bioenergetic impairment and RV dysfunction, which can be reversed by dichloroacetate. ...
The stimulus for PDK upregulation, its isoform specificity, and the long-term effects of PDK inhibition are unknown. We hypothesize t …
ApoA-1 infusion reduces arterial cholesterol and myocardial lesions in a rat model of cardiac dysfunction and insulin resistance.
Borthwick F, Warnakula S, Mangat R, Uwiera RR, Russell JC, Kelly SE, Lee CY, Hryshko L, Mamo JC, Rye KA, Lopaschuk GD, Proctor SD. Borthwick F, et al. Among authors: lopaschuk gd. Atherosclerosis. 2012 Jun;222(2):402-8. doi: 10.1016/j.atherosclerosis.2012.03.006. Epub 2012 Mar 13. Atherosclerosis. 2012. PMID: 22483015
Further, acute rHDL infusion in carotid vessels reduced remnant lipoprotein associated-cholesterol deposition (30-86%; **p<0.01) ex vivo in IR and male Wistar rats and reduced (41%; *p<0.05) the frequency of early-stage myocardial lesions in IR rats. CONCLUSION: Short-te …
Further, acute rHDL infusion in carotid vessels reduced remnant lipoprotein associated-cholesterol deposition (30-86%; **p<0.01) ex vivo …
Long-term effects of intrauterine growth restriction on cardiac metabolism and susceptibility to ischaemia/reperfusion.
Rueda-Clausen CF, Morton JS, Lopaschuk GD, Davidge ST. Rueda-Clausen CF, et al. Among authors: lopaschuk gd. Cardiovasc Res. 2011 May 1;90(2):285-94. doi: 10.1093/cvr/cvq363. Epub 2010 Nov 19. Cardiovasc Res. 2011. PMID: 21097804
The aim of this study was to assess the long-term effect of IUGR on cardiac performance and energy metabolism under aerobic conditions and after ischaemia/reperfusion (IR) injury. ...CONCLUSION: Our results suggest that hypoxia-induced IUGR has long-term effects on …
The aim of this study was to assess the long-term effect of IUGR on cardiac performance and energy metabolism under aerobic condition …
Calorie restriction prevents hypertension and cardiac hypertrophy in the spontaneously hypertensive rat.
Dolinsky VW, Morton JS, Oka T, Robillard-Frayne I, Bagdan M, Lopaschuk GD, Des Rosiers C, Walsh K, Davidge ST, Dyck JR. Dolinsky VW, et al. Among authors: lopaschuk gd. Hypertension. 2010 Sep;56(3):412-21. doi: 10.1161/HYPERTENSIONAHA.110.154732. Epub 2010 Aug 9. Hypertension. 2010. PMID: 20696994
After 5 weeks of either ad libitum feeding or short-term CR, SHRs subjected to short-term CR had lower systolic blood pressure (BP) and reduced left ventricular wall thickness as assessed by noninvasive tail-cuff BP measurements and echocardiography, respectively. . …
After 5 weeks of either ad libitum feeding or short-term CR, SHRs subjected to short-term CR had lower systolic blood pressure …
Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy.
Wang X, Chow FL, Oka T, Hao L, Lopez-Campistrous A, Kelly S, Cooper S, Odenbach J, Finegan BA, Schulz R, Kassiri Z, Lopaschuk GD, Fernandez-Patron C. Wang X, et al. Among authors: lopaschuk gd. Circulation. 2009 May 12;119(18):2480-9. doi: 10.1161/CIRCULATIONAHA.108.835488. Epub 2009 Apr 27. Circulation. 2009. PMID: 19398663
METHODS AND RESULTS: In functional studies, we targeted MMP-7 in rodent models of acute, long-term, and spontaneous hypertension by 3 complementary approaches: (1) Pharmacological inhibition of activity, (2) expression knockdown (by antisense oligodeoxynucleotides and RNA …
METHODS AND RESULTS: In functional studies, we targeted MMP-7 in rodent models of acute, long-term, and spontaneous hypertension by 3 …
Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation.
Zhou L, Huang H, Yuan CL, Keung W, Lopaschuk GD, Stanley WC. Zhou L, et al. Among authors: lopaschuk gd. Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H954-60. doi: 10.1152/ajpheart.00557.2007. Epub 2007 Dec 14. Am J Physiol Heart Circ Physiol. 2008. PMID: 18083904 Free article.
In conclusion, 1) myocardial fatty acid oxidation increases with a short-term increase in cardiac workload, despite an increase in malonyl-CoA concentration, and 2) inhibition of fatty acid oxidation improves LV mechanical efficiency by increasing LV power without affectin …
In conclusion, 1) myocardial fatty acid oxidation increases with a short-term increase in cardiac workload, despite an increase in ma …
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