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Lung function is abnormal in 3-month-old infants with cystic fibrosis diagnosed by newborn screening.
Hoo AF, Thia LP, Nguyen TT, Bush A, Chudleigh J, Lum S, Ahmed D, Balfour Lynn I, Carr SB, Chavasse RJ, Costeloe KL, Price J, Shankar A, Wallis C, Wyatt HA, Wade A, Stocks J; London Cystic Fibrosis Collaboration. Hoo AF, et al. Thorax. 2012 Oct;67(10):874-81. doi: 10.1136/thoraxjnl-2012-201747. Epub 2012 Jun 29. Thorax. 2012. PMID: 22752198
BACKGROUND: Long-term benefits of newborn screening (NBS) for cystic fibrosis (CF) have been established with respect to nutritional status, but effects on pulmonary health remain unclear. ...
BACKGROUND: Long-term benefits of newborn screening (NBS) for cystic fibrosis (CF) have been established with respect to nutritional …
Minimal change in structural, functional and inflammatory markers of lung disease in newborn screened infants with cystic fibrosis at one year.
Davies G, Thia LP, Stocks J, Bush A, Hoo AF, Wade A, Nguyen TTD, Brody AS, Calder A, Klein NJ, Carr SB, Wallis C, Suri R, Pao CS, Ruiz G, Balfour-Lynn IM; London Cystic Fibrosis Collaboration (LCFC). Davies G, et al. J Cyst Fibros. 2020 Nov;19(6):896-901. doi: 10.1016/j.jcf.2020.01.006. Epub 2020 Feb 7. J Cyst Fibros. 2020. PMID: 32044244 Free article.
CONCLUSIONS: In this UK NBS cohort at one year of age, lung and airway damage is much milder and associations between inflammation, abnormal physiology and structural changes were at best weak, contrary to our hypothesis and previously published reports. Continued follow-up will …
CONCLUSIONS: In this UK NBS cohort at one year of age, lung and airway damage is much milder and associations between inflammation, abnormal …