Investigation of the enhanced antitumour potency of STING agonist after conjugation to polymer nanoparticles.
Dosta P, Cryer AM, Dion MZ, Shiraishi T, Langston SP, Lok D, Wang J, Harrison S, Hatten T, Ganno ML, Appleman VA, Taboada GM, Puigmal N, Ferber S, Kalash S, Prado M, Rodríguez AL, Kamoun WS, Abu-Yousif AO, Artzi N.
Dosta P, et al. Among authors: lok d.
Nat Nanotechnol. 2023 Nov;18(11):1351-1363. doi: 10.1038/s41565-023-01447-7. Epub 2023 Jul 13.
Nat Nanotechnol. 2023.
PMID: 37443252
This is shown to increase stability and loading, thereby expanding the therapeutic window in multiple syngeneic tumour models, enabling the study of how the long-term fate of the nanoparticles affects the immune response. In a melanoma mouse model, primary tumour clearance …
This is shown to increase stability and loading, thereby expanding the therapeutic window in multiple syngeneic tumour models, enabling the …