Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles.
Gimona M, Brizzi MF, Choo ABH, Dominici M, Davidson SM, Grillari J, Hermann DM, Hill AF, de Kleijn D, Lai RC, Lai CP, Lim R, Monguió-Tortajada M, Muraca M, Ochiya T, Ortiz LA, Toh WS, Yi YW, Witwer KW, Giebel B, Lim SK.
Gimona M, et al. Among authors: lim sk.
Cytotherapy. 2021 May;23(5):373-380. doi: 10.1016/j.jcyt.2021.01.001. Epub 2021 Apr 10.
Cytotherapy. 2021.
PMID: 33934807
However, it is increasingly clear that MSCs exert their therapeutic functions in a paracrine manner through the secretion of small extracellular vesicles (sEVs) of 50-200 nm in diameter. Unlike living cells that can persist long-term, sEVs are non-living and non-replicativ …
However, it is increasingly clear that MSCs exert their therapeutic functions in a paracrine manner through the secretion of small extracell …