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Prevalence and Clinical Impact of Respiratory Viral Infections from the STOP2 Study of Cystic Fibrosis Pulmonary Exacerbations.
Ann Am Thorac Soc. 2024 Apr;21(4):595-603. doi: 10.1513/AnnalsATS.202306-576OC.
Ann Am Thorac Soc. 2024.
PMID: 37963297
Clinical Trial.
Virus positivity was associated with reduced risk of future PEx (hazard ratio, 0.82; 95% confidence interval, 0.69-0.99; P = 0.034) and longer median time to next PEx (255 d vs. 172 d; P = 0.021) compared with virus negativity.Conclusions: More than one-third of STOP2 participant …
Virus positivity was associated with reduced risk of future PEx (hazard ratio, 0.82; 95% confidence interval, 0.69-0.99; P = 0.034) and long …
Quantifying variation in home spirometry in people with cystic fibrosis during baseline health, and associations with clinical outcomes.
Thornton CS, Magaret AS, Carmody LA, Kalikin LM, Simon RH, LiPuma JJ, Caverly LJ.
Thornton CS, et al. Among authors: lipuma jj.
J Cyst Fibros. 2023 May 25:S1569-1993(23)00141-8. doi: 10.1016/j.jcf.2023.05.011. Online ahead of print.
J Cyst Fibros. 2023.
PMID: 37244842
METHODS: Near-daily home spirometry measurements were obtained from a cohort of pwCF enrolled in a long-term study of the airway microbiome. Associations between the degree of variation in home spirometry and the time to next PEx were evaluated. ...
METHODS: Near-daily home spirometry measurements were obtained from a cohort of pwCF enrolled in a long-term study of the airway micr …
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Maintenance tobramycin primarily affects untargeted bacteria in the CF sputum microbiome.
Nelson MT, Wolter DJ, Eng A, Weiss EJ, Vo AT, Brittnacher MJ, Hayden HS, Ravishankar S, Bautista G, Ratjen A, Blackledge M, McNamara S, Nay L, Majors C, Miller SI, Borenstein E, Simon RH, LiPuma JJ, Hoffman LR.
Nelson MT, et al. Among authors: lipuma jj.
Thorax. 2020 Sep;75(9):780-790. doi: 10.1136/thoraxjnl-2019-214187. Epub 2020 Jul 6.
Thorax. 2020.
PMID: 32631930
Free PMC article.
While the effects of inhaled tobramycin on P. aeruginosa abundance and lung function diminish with continued therapy, this maintenance treatment is known to improve long-term outcomes, underscoring how little is known about why antibiotics work in CF infections, what their …
While the effects of inhaled tobramycin on P. aeruginosa abundance and lung function diminish with continued therapy, this maintenance treat …
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Decade-long bacterial community dynamics in cystic fibrosis airways.
Zhao J, Schloss PD, Kalikin LM, Carmody LA, Foster BK, Petrosino JF, Cavalcoli JD, VanDevanter DR, Murray S, Li JZ, Young VB, LiPuma JJ.
Zhao J, et al. Among authors: lipuma jj.
Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5809-14. doi: 10.1073/pnas.1120577109. Epub 2012 Mar 26.
Proc Natl Acad Sci U S A. 2012.
PMID: 22451929
Free PMC article.
Antibiotic treatment was associated with pronounced shifts in community structure, but communities showed both short- and long-term resilience after antibiotic perturbation. There was a positive correlation between OTU occurrence and relative abundance, with a small number …
Antibiotic treatment was associated with pronounced shifts in community structure, but communities showed both short- and long-term r …
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Microbiological and immunologic considerations with aerosolized drug delivery.
LiPuma JJ.
LiPuma JJ.
Chest. 2001 Sep;120(3 Suppl):118S-123S. doi: 10.1378/chest.120.3_suppl.118s.
Chest. 2001.
PMID: 11555566
Clinical Trial.
The development of drug resistance is a major theoretical concern with the long-term delivery of aerosolized antibiotics via inhalation. A randomized, placebo-controlled, double-blind study, which compared inhaled tobramycin plus standard cystic fibrosis (CF) care to place …
The development of drug resistance is a major theoretical concern with the long-term delivery of aerosolized antibiotics via inhalati …
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