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Analysis of the Li-Fraumeni Spectrum Based on an International Germline TP53 Variant Data Set: An International Agency for Research on Cancer TP53 Database Analysis.
Kratz CP, Freycon C, Maxwell KN, Nichols KE, Schiffman JD, Evans DG, Achatz MI, Savage SA, Weitzel JN, Garber JE, Hainaut P, Malkin D. Kratz CP, et al. JAMA Oncol. 2021 Dec 1;7(12):1800-1805. doi: 10.1001/jamaoncol.2021.4398. JAMA Oncol. 2021. PMID: 34709361 Free PMC article.
DESIGN, SETTING, AND PARTICIPANTS: We analyzed and classified the germline variant data set of the International Agency for Research on Cancer TP53 database that contains data on a cohort of 3034 persons from 1282 families reported in the scientific literature since 1990. We defi …
DESIGN, SETTING, AND PARTICIPANTS: We analyzed and classified the germline variant data set of the International Agency for Research on Canc …
Lithium and suicide prevention in bipolar disorder.
Benard V, Vaiva G, Masson M, Geoffroy PA. Benard V, et al. Encephale. 2016 Jun;42(3):234-41. doi: 10.1016/j.encep.2016.02.006. Epub 2016 Mar 19. Encephale. 2016. PMID: 27000268 Review.
It appears crucial for Li efficacy in suicide prevention to maintain the Li blood concentrations in the efficient therapeutic zone and to instate long-term Li treatment. The "impulsive-aggressive" endophenotype is associated with suicide in BD. ...
It appears crucial for Li efficacy in suicide prevention to maintain the Li blood concentrations in the efficient therapeutic zone and to in …
Single-dispersed polyoxometalate clusters embedded on multilayer graphene as a bifunctional electrocatalyst for efficient Li-S batteries.
Lei J, Fan XX, Liu T, Xu P, Hou Q, Li K, Yuan RM, Zheng MS, Dong QF, Chen JJ. Lei J, et al. Nat Commun. 2022 Jan 11;13(1):202. doi: 10.1038/s41467-021-27866-5. Nat Commun. 2022. PMID: 35017484 Free PMC article.
Due to the interfacial charge transfer and exposure of unsaturated cobalt sites, the composite demonstrates efficient polysulfides adsorption and reduced activation energy for polysulfides conversion, thus serving as a bifunctional electrocatalyst. When tested in full Li-S …
Due to the interfacial charge transfer and exposure of unsaturated cobalt sites, the composite demonstrates efficient polysulfides adsorptio …
Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids.
Osete JR, Akkouh IA, Ievglevskyi O, Vandenberghe M, de Assis DR, Ueland T, Kondratskaya E, Holen B, Szabo A, Hughes T, Smeland OB, Steen VM, Andreassen OA, Djurovic S. Osete JR, et al. Mol Psychiatry. 2023 Jul;28(7):3033-3043. doi: 10.1038/s41380-023-01944-0. Epub 2023 Jan 18. Mol Psychiatry. 2023. PMID: 36653674 Free PMC article.
Moreover, Li regulated secretion of pro-inflammatory cytokines and increased mitochondrial reserve capacity in BD hCS. Through long-term Li treatment of a human 3D brain model, this study partly elucidates the functional and transcriptional mechanisms underlying the …
Moreover, Li regulated secretion of pro-inflammatory cytokines and increased mitochondrial reserve capacity in BD hCS. Through long-term …
Exploring the genetics of lithium response in bipolar disorders.
Herrera-Rivero M, Adli M, Akiyama K, Akula N, Amare AT, Ardau R, Arias B, Aubry JM, Backlund L, Bellivier F, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Cearns M, Cervantes P, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cruceanu C, Czerski PM, Dalkner N, Degenhardt F, Del Zompo M, DePaulo JR, Etain B, Falkai P, Ferensztajn-Rochowiak E, Forstner AJ, Frank J, Frisén L, Frye MA, Fullerton JM, Gallo C, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hasler R, Hauser J, Heilbronner U, Herms S, Hoffmann P, Hou L, Hsu YH, Jamain S, Jiménez E, Kahn JP, Kassem L, Kato T, Kelsoe J, Kittel-Schneider S, Kuo PH, Kusumi I, König B, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Maj M, Manchia M, Marie-Claire C, Martinsson L, McCarthy MJ, McElroy SL, Millischer V, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Novák T, Nöthen MM, O'Donovan C, Ozaki N, Papiol S, Pfennig A, Pisanu C, Potash JB, Reif A, Reininghaus E, Richard-Lepouriel H, Roberts G, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schubert KO, Schulte EC, Schweizer BW, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Sta… See abstract for full author list ➔ Herrera-Rivero M, et al. Res Sq [Preprint]. 2023 Dec 2:rs.3.rs-3677630. doi: 10.21203/rs.3.rs-3677630/v1. Res Sq. 2023. PMID: 38077040 Free PMC article. Preprint.
BP-I and BP-II) according to the clinical presentation. Moreover, long-term Li treatment has been linked to adverse side-effects that are a cause of concern and non-adherence, including the risk of developing chronic medical conditions such as thyroid and renal dise …
BP-I and BP-II) according to the clinical presentation. Moreover, long-term Li treatment has been linked to adverse side-effec …
The Relationship Between Lithium and Cancer Proliferation: A Case-Based Review of the Literature.
Ozerdem A, Ceylan D, Targıtay B. Ozerdem A, et al. Curr Drug Metab. 2018;19(8):653-662. doi: 10.2174/1389200219666180430095933. Curr Drug Metab. 2018. PMID: 29708074 Review.
RESULTS: The limited data on the relationship between Li and cancer proliferation in clinical populations support neither a positive relationship between long-term Li use and increased urinary tract cancers nor an overall cancer risk. ...CONCLUSION: Despite the pres …
RESULTS: The limited data on the relationship between Li and cancer proliferation in clinical populations support neither a positive relatio …
Three-Dimensional Anionic Cyclodextrin-Based Covalent Organic Frameworks.
Zhang Y, Duan J, Ma D, Li P, Li S, Li H, Zhou J, Ma X, Feng X, Wang B. Zhang Y, et al. Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16313-16317. doi: 10.1002/anie.201710633. Epub 2017 Nov 22. Angew Chem Int Ed Engl. 2017. PMID: 29106041
The inclusion of pliable moieties in the robust open framework endows these CD-COFs with dynamic features, leading to a prominent Li ion conductivity of up to 2.7 mS cm(-1) at 30 C and excellent long-term Li ion stripping/plating stability. Exchanging the counterion …
The inclusion of pliable moieties in the robust open framework endows these CD-COFs with dynamic features, leading to a prominent Li ion con …
Genotype-phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry.
Penkert J, Strüwe FJ, Dutzmann CM, Doergeloh BB, Montellier E, Freycon C, Keymling M, Schlemmer HP, Sänger B, Hoffmann B, Gerasimov T, Blattmann C, Fetscher S, Frühwald M, Hettmer S, Kordes U, Ridola V, Kroiss Benninger S, Mastronuzzi A, Schott S, Nees J, Prokop A, Redlich A, Seidel MG, Zimmermann S, Pajtler KW, Pfister SM, Hainaut P, Kratz CP. Penkert J, et al. J Hematol Oncol. 2022 Aug 16;15(1):107. doi: 10.1186/s13045-022-01332-1. J Hematol Oncol. 2022. PMID: 35974385 Free PMC article.
The condition represents one of the most relevant genetic causes of cancer in children and adults due to its frequency and high cancer risk. The term Li-Fraumeni spectrum reflects the evolving phenotypic variability of the condition. ...
The condition represents one of the most relevant genetic causes of cancer in children and adults due to its frequency and high cancer risk. …
Lithium Treatment Induces Cardiac Dysfunction in Mice.
L'Abbate S, Nicolini G, Marchetti S, Forte G, Lepore E, Unfer V, Kusmic C. L'Abbate S, et al. Int J Mol Sci. 2023 Nov 1;24(21):15872. doi: 10.3390/ijms242115872. Int J Mol Sci. 2023. PMID: 37958854 Free PMC article.
Concerns about its toxicity and negative impact on the heart have recently been raised. We investigated the effects of long-term Li treatment on the heart, liver, and kidney in mice. Sixteen C57BL/6J mice were randomly assigned to receive oral administration of Li c …
Concerns about its toxicity and negative impact on the heart have recently been raised. We investigated the effects of long-term L …
Hybrid asset localization using light fidelity and Bluetooth Low Energy.
Albraheem L, Alshathri H, Alsheddi R, Alotaibi R, Alkharashi G. Albraheem L, et al. PLoS One. 2022 Sep 29;17(9):e0274452. doi: 10.1371/journal.pone.0274452. eCollection 2022. PLoS One. 2022. PMID: 36173962 Free PMC article.
It has been proven that visible light can be used to transfer data. A German physicist, Harald Haas, introduced the term "Li-Fi", which stands for "light fidelity", as a new technology that uses light as a medium to deliver data. ...In addition, the mobile applicati …
It has been proven that visible light can be used to transfer data. A German physicist, Harald Haas, introduced the term "Li-F …
26 results