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Lithium Treatment Induces Cardiac Dysfunction in Mice.
L'Abbate S, Nicolini G, Marchetti S, Forte G, Lepore E, Unfer V, Kusmic C. L'Abbate S, et al. Int J Mol Sci. 2023 Nov 1;24(21):15872. doi: 10.3390/ijms242115872. Int J Mol Sci. 2023. PMID: 37958854 Free PMC article.
Concerns about its toxicity and negative impact on the heart have recently been raised. We investigated the effects of long-term Li treatment on the heart, liver, and kidney in mice. Sixteen C57BL/6J mice were randomly assigned to receive oral administration of Li c …
Concerns about its toxicity and negative impact on the heart have recently been raised. We investigated the effects of long-term L …
Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids.
Osete JR, Akkouh IA, Ievglevskyi O, Vandenberghe M, de Assis DR, Ueland T, Kondratskaya E, Holen B, Szabo A, Hughes T, Smeland OB, Steen VM, Andreassen OA, Djurovic S. Osete JR, et al. Mol Psychiatry. 2023 Jul;28(7):3033-3043. doi: 10.1038/s41380-023-01944-0. Epub 2023 Jan 18. Mol Psychiatry. 2023. PMID: 36653674 Free PMC article.
Moreover, Li regulated secretion of pro-inflammatory cytokines and increased mitochondrial reserve capacity in BD hCS. Through long-term Li treatment of a human 3D brain model, this study partly elucidates the functional and transcriptional mechanisms underlying the …
Moreover, Li regulated secretion of pro-inflammatory cytokines and increased mitochondrial reserve capacity in BD hCS. Through long-term …
Genotype-phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry.
Penkert J, Strüwe FJ, Dutzmann CM, Doergeloh BB, Montellier E, Freycon C, Keymling M, Schlemmer HP, Sänger B, Hoffmann B, Gerasimov T, Blattmann C, Fetscher S, Frühwald M, Hettmer S, Kordes U, Ridola V, Kroiss Benninger S, Mastronuzzi A, Schott S, Nees J, Prokop A, Redlich A, Seidel MG, Zimmermann S, Pajtler KW, Pfister SM, Hainaut P, Kratz CP. Penkert J, et al. J Hematol Oncol. 2022 Aug 16;15(1):107. doi: 10.1186/s13045-022-01332-1. J Hematol Oncol. 2022. PMID: 35974385 Free PMC article.
The condition represents one of the most relevant genetic causes of cancer in children and adults due to its frequency and high cancer risk. The term Li-Fraumeni spectrum reflects the evolving phenotypic variability of the condition. ...
The condition represents one of the most relevant genetic causes of cancer in children and adults due to its frequency and high cancer risk. …
New Horizons for Conventional Lithium Ion Battery Technology.
Erickson EM, Ghanty C, Aurbach D. Erickson EM, et al. J Phys Chem Lett. 2014 Oct 2;5(19):3313-24. doi: 10.1021/jz501387m. Epub 2014 Sep 15. J Phys Chem Lett. 2014. PMID: 26278438
This article concentrates on Li intercalation and Li alloying electrodes, relevant to the term Li ion batteries....
This article concentrates on Li intercalation and Li alloying electrodes, relevant to the term Li ion batteries....
Solid renal tumours of collecting duct origin in patients on chronic lithium therapy.
Rookmaaker MB, van Gerven HA, Goldschmeding R, Boer WH. Rookmaaker MB, et al. Clin Kidney J. 2012 Oct;5(5):412-5. doi: 10.1093/ckj/sfs091. Clin Kidney J. 2012. PMID: 26019817 Free PMC article.
BACKGROUND: Lithium (Li) is an invaluable drug for the treatment of bipolar disorder. Long-term Li use is associated with renal complications including the formation of uncomplicated renal cysts caused by proliferation and expansion of collecting duct (CD) cells. .. …
BACKGROUND: Lithium (Li) is an invaluable drug for the treatment of bipolar disorder. Long-term Li use is associated with rena …
Lithium chloride at a therapeutic concentration reduces Ca2+ response in protein kinase C down-regulated human astrocytoma cells.
Kurita M, Mashiko H, Rai M, Kumasaka T, Kouno Si, Niwa Si, Nakahata N. Kurita M, et al. Eur J Pharmacol. 2002 May 3;442(1-2):17-22. doi: 10.1016/s0014-2999(02)01491-7. Eur J Pharmacol. 2002. PMID: 12020677
Since the therapeutic efficacy of Li+ in the treatment of mood disorder is observed only after chronic administration, we examined whether long-term Li+ treatment with a therapeutic concentration affected the elevation of intracellular-free Ca2+ concentration ([Ca2+ …
Since the therapeutic efficacy of Li+ in the treatment of mood disorder is observed only after chronic administration, we examined whether l …
Gabapentin does not alter single-dose lithium pharmacokinetics.
Frye MA, Kimbrell TA, Dunn RT, Piscitelli S, Grothe D, Vanderham E, Corá-Locatelli G, Post RM, Ketter TA. Frye MA, et al. J Clin Psychopharmacol. 1998 Dec;18(6):461-4. doi: 10.1097/00004714-199812000-00008. J Clin Psychopharmacol. 1998. PMID: 9864078 Clinical Trial.
These data indicate that gabapentin treatment at this high therapeutic dose does not cause clinically significant alterations in short-term Li pharmacokinetics in patients with normal renal function. ...
These data indicate that gabapentin treatment at this high therapeutic dose does not cause clinically significant alterations in short-te …