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A practical guide to the appropriate analysis of eGFR data over time: A simulation study.
DeVries T, Carroll KJ, Lewis SA. DeVries T, et al. Among authors: lewis sa. Pharm Stat. 2024 Apr 3. doi: 10.1002/pst.2381. Online ahead of print. Pharm Stat. 2024. PMID: 38568372
In several therapeutic areas, including chronic kidney disease (CKD) and immunoglobulin A nephropathy (IgAN), there is a growing interest in how best to analyze estimated glomerular filtration rate (eGFR) data over time in randomized clinical trials including how to best accommod …
In several therapeutic areas, including chronic kidney disease (CKD) and immunoglobulin A nephropathy (IgAN), there is a growing interest in …
HMGB2 regulates the differentiation and stemness of exhausted CD8+ T cells during chronic viral infection and cancer.
Neubert EN, DeRogatis JM, Lewis SA, Viramontes KM, Ortega P, Henriquez ML, Buisson R, Messaoudi I, Tinoco R. Neubert EN, et al. Among authors: lewis sa. Nat Commun. 2023 Sep 13;14(1):5631. doi: 10.1038/s41467-023-41352-0. Nat Commun. 2023. PMID: 37704621 Free PMC article.
Despite Hmgb2(-/-) CD8(+) T cells expressing TCF-1 and TOX, these master regulators were unable to sustain Tpex differentiation and long-term survival during persistent antigen. Furthermore, HMGB2 also had a cell-intrinsic function in the differentiation and function of me …
Despite Hmgb2(-/-) CD8(+) T cells expressing TCF-1 and TOX, these master regulators were unable to sustain Tpex differentiation and long- …
Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation.
Lewis SA, Shetty S, Gamble S, Heim J, Zhao N, Stitt G, Pankratz M, Mangum T, Marku I, Rosenberg RB, Wilfong AA, Fahey MC, Kim S, Myers SJ, Appavu B, Kruer MC. Lewis SA, et al. Orphanet J Rare Dis. 2023 Aug 3;18(1):225. doi: 10.1186/s13023-023-02756-9. Orphanet J Rare Dis. 2023. PMID: 37537625 Free PMC article.
CONCLUSION: Although the invasive nature of the trial necessitated a short-term, non-randomized, unblinded intervention, quantitative longitudinal neurophysiologic monitoring indicated benefit, providing class II evidence in support of intrathecal MgSO(4) for select forms …
CONCLUSION: Although the invasive nature of the trial necessitated a short-term, non-randomized, unblinded intervention, quantitative …
Ethanol Consumption Induces Nonspecific Inflammation and Functional Defects in Alveolar Macrophages.
Lewis SA, Doratt BM, Sureshchandra S, Jankeel A, Newman N, Shen W, Grant KA, Messaoudi I. Lewis SA, et al. Am J Respir Cell Mol Biol. 2022 Jul;67(1):112-124. doi: 10.1165/rcmb.2021-0346OC. Am J Respir Cell Mol Biol. 2022. PMID: 35380939 Free PMC article.
In this study, we use a rhesus macaque model of voluntary ethanol self-administration to study the effects of long-term alcohol drinking on the immunological landscape of the lung. ...
In this study, we use a rhesus macaque model of voluntary ethanol self-administration to study the effects of long-term alcohol drink …
Profiling of extracellular vesicle-bound miRNA to identify candidate biomarkers of chronic alcohol drinking in nonhuman primates.
Lewis SA, Doratt B, Sureshchandra S, Pan T, Gonzales SW, Shen W, Grant KA, Messaoudi I. Lewis SA, et al. Alcohol Clin Exp Res. 2022 Feb;46(2):221-231. doi: 10.1111/acer.14760. Epub 2021 Dec 29. Alcohol Clin Exp Res. 2022. PMID: 34910314 Free PMC article.
BACKGROUND: Long-term alcohol drinking is associated with numerous health complications including susceptibility to infection, cancer, and organ damage. ...CONCLUSION: This exploratory study identified several EV-miRNAs that could serve as biomarkers of long-term al …
BACKGROUND: Long-term alcohol drinking is associated with numerous health complications including susceptibility to infection, cancer …
Development of a Yoga Program for Type-2 Diabetes Prevention (YOGA-DP) Among High-Risk People in India.
Chattopadhyay K, Mishra P, Manjunath NK, Harris T, Hamer M, Greenfield SM, Wang H, Singh K, Lewis SA, Tandon N, Kinra S, Prabhakaran D. Chattopadhyay K, et al. Among authors: lewis sa. Front Public Health. 2020 Nov 17;8:548674. doi: 10.3389/fpubh.2020.548674. eCollection 2020. Front Public Health. 2020. PMID: 33313032 Free PMC article.
Once participants complete the program, they are strongly encouraged to maintain a healthy lifestyle in the long-term. Conclusions: We systematically developed a novel Yoga program for T2DM prevention (YOGA-DP) among high-risk people in India. ...
Once participants complete the program, they are strongly encouraged to maintain a healthy lifestyle in the long-term. Conclusions: W …
Analysis of outcomes for intravitreal bevacizumab in the treatment of choroidal neovascularization secondary to ocular histoplasmosis.
Cionni DA, Lewis SA, Petersen MR, Foster RE, Riemann CD, Sisk RA, Hutchins RK, Miller DM. Cionni DA, et al. Among authors: lewis sa. Ophthalmology. 2012 Feb;119(2):327-32. doi: 10.1016/j.ophtha.2011.08.032. Epub 2011 Nov 30. Ophthalmology. 2012. PMID: 22133795
PURPOSE: To assess the long-term outcomes of intravitreal bevacizumab (IVB) in the treatment of choroidal neovascularization (CNV) secondary to presumed ocular histoplasmosis syndrome (POHS). ...
PURPOSE: To assess the long-term outcomes of intravitreal bevacizumab (IVB) in the treatment of choroidal neovascularization (CNV) se …
Knowledge and information needs of young people with epilepsy and their parents: Mixed-method systematic review.
Lewis SA, Noyes J, Mackereth S. Lewis SA, et al. BMC Pediatr. 2010 Dec 31;10:103. doi: 10.1186/1471-2431-10-103. BMC Pediatr. 2010. PMID: 21194484 Free PMC article. Review.
BACKGROUND: Young people with neurological impairments such as epilepsy are known to receive less adequate services compared to young people with other long-term conditions. The time (age 13-19 years) around transition to adult services is particularly important in facilit …
BACKGROUND: Young people with neurological impairments such as epilepsy are known to receive less adequate services compared to young people …
25 results