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Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study.
Chanchlani N, Lin S, Bewshea C, Hamilton B, Thomas A, Smith R, Roberts C, Bishara M, Nice R, Lees CW, Sebastian S, Irving PM, Russell RK, McDonald TJ, Goodhand JR, Ahmad T, Kennedy NA; PANTS Consortium. Chanchlani N, et al. Lancet Gastroenterol Hepatol. 2024 Apr 16:S2468-1253(24)00044-X. doi: 10.1016/S2468-1253(24)00044-X. Online ahead of print. Lancet Gastroenterol Hepatol. 2024. PMID: 38640937
Low drug concentrations at the end of the induction period predict loss of response by year 3 of treatment, suggesting higher drug concentrations during the first year of treatment, particularly during induction, might lead to better long-term outcomes. Anti-drug antibodie …
Low drug concentrations at the end of the induction period predict loss of response by year 3 of treatment, suggesting higher drug concentra …
"The anxiety coming up to every scan-It destroyed me": A qualitative study of the lived experience of cytomegalovirus infection during pregnancy.
Tripathi T, Watson J, Skrzypek H, Stump H, Lewis S, Hui L. Tripathi T, et al. Among authors: lewis s. Prenat Diagn. 2024 Apr 5. doi: 10.1002/pd.6564. Online ahead of print. Prenat Diagn. 2024. PMID: 38578535
Interview transcripts were analyzed using inductive content analysis. RESULTS: Twelve participants were interviewed: 6 had a live birth, 4 had terminations of pregnancy, 1 had a neonatal death and 1 was pregnant at the time of interview. ...The pregnancy and postpartum per …
Interview transcripts were analyzed using inductive content analysis. RESULTS: Twelve participants were interviewed: 6 had a live birth …
A practical guide to the appropriate analysis of eGFR data over time: A simulation study.
DeVries T, Carroll KJ, Lewis SA. DeVries T, et al. Among authors: lewis sa. Pharm Stat. 2024 Apr 3. doi: 10.1002/pst.2381. Online ahead of print. Pharm Stat. 2024. PMID: 38568372
In several therapeutic areas, including chronic kidney disease (CKD) and immunoglobulin A nephropathy (IgAN), there is a growing interest in how best to analyze estimated glomerular filtration rate (eGFR) data over time in randomized clinical trials including how to best accommod …
In several therapeutic areas, including chronic kidney disease (CKD) and immunoglobulin A nephropathy (IgAN), there is a growing interest in …
Factors Associated with the Maintenance of Cost-Effectiveness at 5 Years in Adult Spinal Deformity Corrective Surgery.
Passias PG, Mir JM, Dave P, Smith JS, Lafage R, Gum J, Line BG, Diebo B, Daniels AH, Hamilton DK, Buell TJ, Scheer JK, Eastlack RK, Mullin JP, Mundis GM, Hosogane N, Yagi M, Schoenfeld AJ, Uribe JS, Anand N, Mummaneni PV, Chou D, Klineberg EO, Kebaish KM, Lewis SJ, Gupta MC, Kim HJ, Hart RA, Lenke LG, Ames CP, Shaffrey CI, Schwab FJ, Lafage V, Hostin RA Jr, Bess S, Burton DC; International Spine Study Group. Passias PG, et al. Among authors: lewis sj. Spine (Phila Pa 1976). 2024 Mar 11. doi: 10.1097/BRS.0000000000004982. Online ahead of print. Spine (Phila Pa 1976). 2024. PMID: 38462731
STUDY DESIGN: Retrospective cohort. OBJECTIVE: To evaluate factors associated with the long-term durability of cost-effectiveness (CE) in ASD patients. BACKGROUND: A substantial increase in costs associated with the surgical treatment for adult spinal deformity (ASD) has g …
STUDY DESIGN: Retrospective cohort. OBJECTIVE: To evaluate factors associated with the long-term durability of cost-effectiveness (CE …
Neurostimulation for Advanced Parkinson Disease and Quality of Life at 5 Years: A Nonrandomized Controlled Trial.
Jost ST, Aloui S, Evans J, Ashkan K, Sauerbier A, Rizos A, Petry-Schmelzer JN, Gronostay A, Fink GR, Visser-Vandewalle V, Antonini A, Silverdale M, Timmermann L, Martinez-Martin P, Chaudhuri KR, Dafsari HS; International Parkinson and Movement Disorders Society Non-Motor Parkinson’s Disease Study Group and EUROPAR. Jost ST, et al. JAMA Netw Open. 2024 Jan 2;7(1):e2352177. doi: 10.1001/jamanetworkopen.2023.52177. JAMA Netw Open. 2024. PMID: 38236600 Free PMC article. Clinical Trial.
However, controlled studies with more than 3 years of follow-up are lacking. OBJECTIVE: To investigate the long-term effects of STN-DBS on QOL compared with standard-of-care medication (MED). ...The association between changes in QOL and ADL, but not motor impairment or co …
However, controlled studies with more than 3 years of follow-up are lacking. OBJECTIVE: To investigate the long-term effects of STN-D …
Utility of nifedipine use for Doppler ultrasound early after liver transplantation to predict short-term complications and long-term outcomes.
Kadaba P, Beitia L, Rosen A, Weinberg A, Lewis S, Simpson WL. Kadaba P, et al. Among authors: lewis s. Abdom Radiol (NY). 2024 Apr;49(4):1103-1112. doi: 10.1007/s00261-023-04152-0. Epub 2024 Jan 14. Abdom Radiol (NY). 2024. PMID: 38219253
PURPOSE: To evaluate the response to nifedipine administration measured by changes in hepatic arterial (HA) flow on post-operative Doppler ultrasound (US) to predict short-term complications and long-term outcomes in liver transplant (LT) patients. ...The responder …
PURPOSE: To evaluate the response to nifedipine administration measured by changes in hepatic arterial (HA) flow on post-operative Doppler u …
Gene therapy with bidridistrogene xeboparvovec for limb-girdle muscular dystrophy type 2E/R4: phase 1/2 trial results.
Mendell JR, Pozsgai ER, Lewis S, Griffin DA, Lowes LP, Alfano LN, Lehman KJ, Church K, Reash NF, Iammarino MA, Sabo B, Potter R, Neuhaus S, Li X, Stevenson H, Rodino-Klapac LR. Mendell JR, et al. Among authors: lewis s. Nat Med. 2024 Jan;30(1):199-206. doi: 10.1038/s41591-023-02730-9. Epub 2024 Jan 4. Nat Med. 2024. PMID: 38177855 Free PMC article. Clinical Trial.
The 2-year safety and efficacy of bidridistrogene xeboparvovec support clinical development advancement. Further studies are necessary to confirm the long-term safety and efficacy of this gene therapy. ClinicalTrials.gov registration: NCT03652259 ....
The 2-year safety and efficacy of bidridistrogene xeboparvovec support clinical development advancement. Further studies are necessary to co …
Safety and efficacy of doravirine as first-line therapy in adults with HIV-1: week 192 results from the open-label extensions of the DRIVE-FORWARD and DRIVE-AHEAD phase 3 trials.
Orkin C, Molina JM, Cahn P, Lombaard J, Supparatpinyo K, Kumar S, Campbell H, Wan H, Teal V, Jin Xu Z, Asante-Appiah E, Sklar P, Teppler H, Lahoulou R; DRIVE-FORWARD and DRIVE-AHEAD collaborators. Orkin C, et al. Lancet HIV. 2024 Feb;11(2):e75-e85. doi: 10.1016/S2352-3018(23)00258-8. Epub 2023 Dec 20. Lancet HIV. 2024. PMID: 38141637 Clinical Trial.
INTERPRETATION: Favourable efficacy and safety profiles for doravirine at week 96 were maintained through to week 192 in participants who continued or switched to doravirine, supporting use of doravirine for long-term first-line HIV-1 treatment and for virologically suppre …
INTERPRETATION: Favourable efficacy and safety profiles for doravirine at week 96 were maintained through to week 192 in participants who co …
Politicians, experts, and patient representatives call for the UK government to reverse the rate of antidepressant prescribing.
Davies J, Read J, Kruger D, Crisp N, Lamb N, Dixon M, Everington S, Hollins S, Moncrieff J, Giurca BC, van Tulleken C, Chouinard G, Dooley M, Guy A, Horowitz M, Kinderman P, Johnstone L, Montagu L, Nardi AE, Stacey S, Bell M, Tresidder A, Watson J, Lewis S, Spada M, Payne R, Akhtar N, Buckland C, Levett J, Whitcombe S, Marshall-Andrews L. Davies J, et al. Among authors: lewis s. BMJ. 2023 Dec 5;383:2730. doi: 10.1136/bmj.p2730. BMJ. 2023. PMID: 38052460 No abstract available.
Surgical versus non-surgical interventions for displaced intra-articular calcaneal fractures.
Lewis SR, Pritchard MW, Solomon JL, Griffin XL, Bruce J. Lewis SR, et al. Cochrane Database Syst Rev. 2023 Nov 7;11(11):CD008628. doi: 10.1002/14651858.CD008628.pub3. Cochrane Database Syst Rev. 2023. PMID: 37933733 Review.
We collected data for the following outcomes: function in the short term (within three months of injury) or long term (more than three months after injury), chronic pain, health-related quality of life (HRQoL) and ability to return to normal activities, as well as c …
We collected data for the following outcomes: function in the short term (within three months of injury) or long term (more th …
383 results