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Radiology-based diagnosis of fungal pulmonary infections in high-risk hematology patients: are we making progress?
Lewis RE, Stanzani M, Morana G, Sassi C. Lewis RE, et al. Curr Opin Infect Dis. 2023 Aug 1;36(4):250-256. doi: 10.1097/QCO.0000000000000937. Epub 2023 Jun 9. Curr Opin Infect Dis. 2023. PMID: 37431554 Free PMC article. Review.
MRI-based approaches also show promise not only for early detection of small nodules and alveolar hemorrhage but can also be used to detect pulmonary vascular occlusion without radiation and iodinated contrast media. 18F-fluorodeoxyglucose (FDG) PET/computed tomography (FDG-PET/C …
MRI-based approaches also show promise not only for early detection of small nodules and alveolar hemorrhage but can also be used to detect …
Long-Term Outcome After Adoptive Immunotherapy With Natural Killer Cells: Alloreactive NK Cell Dose Still Matters.
Parisi S, Ruggeri L, Dan E, Rizzi S, Sinigaglia B, Ocadlikova D, Bontadini A, Giudice V, Urbani E, Ciardelli S, Sartor C, Cristiano G, Nanni J, Zannoni L, Chirumbolo G, Arpinati M, Lewis RE, Bonifazi F, Marconi G, Martinelli G, Papayannidis C, Paolini S, Velardi A, Cavo M, Lemoli RM, Curti A. Parisi S, et al. Among authors: lewis re. Front Immunol. 2022 Jan 31;12:804988. doi: 10.3389/fimmu.2021.804988. eCollection 2021. Front Immunol. 2022. PMID: 35173709 Free PMC article.
Management of drug-drug interactions of targeted therapies for haematological malignancies and triazole antifungal drugs.
Brüggemann RJ, Verheggen R, Boerrigter E, Stanzani M, Verweij PE, Blijlevens NMA, Lewis RE. Brüggemann RJ, et al. Among authors: lewis re. Lancet Haematol. 2022 Jan;9(1):e58-e72. doi: 10.1016/S2352-3026(21)00232-5. Epub 2021 Dec 8. Lancet Haematol. 2022. PMID: 34890539 Review.
However, most of these new drugs undergo extensive hepatic metabolism and exhibit moderate to severe drug-drug interactions with triazole antifungal agents, which are essential for the prophylaxis and long-term treatment of invasive fungal infections. In this Review, we gi …
However, most of these new drugs undergo extensive hepatic metabolism and exhibit moderate to severe drug-drug interactions with triazole an …
Prognostic Role of Bacterial and Fungal Infections in Patients With Liver Cirrhosis With and Without Acute-on-Chronic Liver Failure: A Prospective 2-Center Study.
Bartoletti M, Baldassarre M, Domenicali M, Lewis RE, Giannella M, Antognoli A, Rinaldi M, Zaccherini G, Verucchi G, Marconi L, Tamè M, Berardi S, Napoli L, Siniscalchi A, Fabbri A, Biselli M, Tufoni M, Pavarin RM, Trevisani F, Viale P, Bernardi M, Caraceni P. Bartoletti M, et al. Among authors: lewis re. Open Forum Infect Dis. 2020 Nov 4;7(11):ofaa453. doi: 10.1093/ofid/ofaa453. eCollection 2020 Nov. Open Forum Infect Dis. 2020. PMID: 33209950 Free PMC article.
Competing risk analysis showed that the negative impact of ACLF-related BFI on long-term prognosis was independent from Model for End-stage Liver Disease (MELD) incorporating serum sodium concentration score, comorbidity, and basal C-reactive protein level. ...CONCLUSIONS: …
Competing risk analysis showed that the negative impact of ACLF-related BFI on long-term prognosis was independent from Model for End …
Risk factors for recurrent carbapenem resistant Klebsiella pneumoniae bloodstream infection: a prospective cohort study.
Giannella M, Graziano E, Marconi L, Girometti N, Bartoletti M, Tedeschi S, Tumietto F, Cristini F, Ambretti S, Berlingeri A, Lewis RE, Viale P. Giannella M, et al. Among authors: lewis re. Eur J Clin Microbiol Infect Dis. 2017 Oct;36(10):1965-1970. doi: 10.1007/s10096-017-3020-x. Epub 2017 Jun 1. Eur J Clin Microbiol Infect Dis. 2017. PMID: 28567543
Recurrence is frequent among patients cured of a CR-KP BSI and is associated with higher long-term mortality. When feasible, source control is mandatory to avoid recurrence. ...
Recurrence is frequent among patients cured of a CR-KP BSI and is associated with higher long-term mortality. When feasible, source c …
Toll-like receptor (TLR) expression of immune system cells from metastatic breast cancer patients with circulating tumor cells.
Green TL, Santos MF, Ejaeidi AA, Craft BS, Lewis RE, Cruse JM. Green TL, et al. Among authors: lewis re. Exp Mol Pathol. 2014 Aug;97(1):44-8. doi: 10.1016/j.yexmp.2014.05.003. Epub 2014 May 14. Exp Mol Pathol. 2014. PMID: 24836676
However, the good intentions of TLRs are sometimes not transferred to positive long-term effects, due to their involvement in exacerbating inflammatory effects and even contributing to continued inflammation. ...Circulating tumor cells (CTCs) are neoplastic cells present i …
However, the good intentions of TLRs are sometimes not transferred to positive long-term effects, due to their involvement in exacerb …
Defining the role of echinocandin catechol functional groups in the development of secondary hepatocellular carcinoma.
Julius JM, Gaikwad A, Lowry A, Lewis RE, Lozano RD, Dalrymple JL, Coleman RL, Smith JA. Julius JM, et al. Among authors: lewis re. J Antimicrob Chemother. 2012 Feb;67(2):422-9. doi: 10.1093/jac/dkr494. Epub 2011 Nov 30. J Antimicrob Chemother. 2012. PMID: 22129592
CONCLUSIONS: At clinically achievable concentrations only B(0)C significantly inhibited COMT activity and increased CE concentrations. Short-term exposure did not alter the rate of cancer cell growth. Confirmation is needed to determine the clinical impact of long-term …
CONCLUSIONS: At clinically achievable concentrations only B(0)C significantly inhibited COMT activity and increased CE concentrations. Short …
Current concepts in antifungal pharmacology.
Lewis RE. Lewis RE. Mayo Clin Proc. 2011 Aug;86(8):805-17. doi: 10.4065/mcp.2011.0247. Mayo Clin Proc. 2011. PMID: 21803962 Free PMC article. Review.
Yet, many of these newer antifungal agents have important limitations in their spectrum of activity, pharmacokinetics, and unique predisposition for pharmacokinetic drug-drug interactions and unusual toxicities associated with long-term use. This article reviews key pharma …
Yet, many of these newer antifungal agents have important limitations in their spectrum of activity, pharmacokinetics, and unique predisposi …
How I treat mucormycosis.
Kontoyiannis DP, Lewis RE. Kontoyiannis DP, et al. Among authors: lewis re. Blood. 2011 Aug 4;118(5):1216-24. doi: 10.1182/blood-2011-03-316430. Epub 2011 May 26. Blood. 2011. PMID: 21622653 Free PMC article. Review.
The availability of posaconazole in an oral formulation that can be administered safely for prolonged periods makes it an attractive agent for long-term primary and secondary prophylaxis. However, serum drug concentration monitoring may be required to minimize breakthrough …
The availability of posaconazole in an oral formulation that can be administered safely for prolonged periods makes it an attractive agent f …
Azoles and antidepressants: a mini-review of the tolerability of co-administration.
Roussos P, Lewis RE, Kontoyiannis DP. Roussos P, et al. Among authors: lewis re. Mycoses. 2009 Sep;52(5):433-9. doi: 10.1111/j.1439-0507.2008.01677.x. Epub 2009 Jan 21. Mycoses. 2009. PMID: 19207836 Review.
Depression is a common condition in chronically ill immunosuppressed patients on long-term antifungal therapy with azoles. As both azoles and more recent antifungals are metabolised by the P450 enzymatic system in the liver, here we review the potential of clinically meani …
Depression is a common condition in chronically ill immunosuppressed patients on long-term antifungal therapy with azoles. As both az …
15 results