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Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis.
Kedia K, Wendler JP, Baker ES, Burnum-Johnson KE, Jarsberg LG, Stratton KG, Wright AT, Piehowski PD, Gritsenko MA, Lewinsohn DM, Sigal GB, Weiner MH, Smith RD, Jacobs JM, Nahid P. Kedia K, et al. Among authors: lewinsohn dm. Tuberculosis (Edinb). 2018 Sep;112:52-61. doi: 10.1016/j.tube.2018.07.005. Epub 2018 Jul 18. Tuberculosis (Edinb). 2018. PMID: 30205969 Free PMC article. Clinical Trial.
A repeating set of serum proteins (TTHY, AFAM, CRP, RET4, SAA1, PGRP2, among others) were found to change significantly in response to treatment, to strongly correlate with culture status, and at baseline to be predictive of future culture conversion. If validated in cohorts with …
A repeating set of serum proteins (TTHY, AFAM, CRP, RET4, SAA1, PGRP2, among others) were found to change significantly in response to treat …
Polyfunctional CD4+ T Cells As Targets for Tuberculosis Vaccination.
Lewinsohn DA, Lewinsohn DM, Scriba TJ. Lewinsohn DA, et al. Among authors: lewinsohn dm. Front Immunol. 2017 Oct 5;8:1262. doi: 10.3389/fimmu.2017.01262. eCollection 2017. Front Immunol. 2017. PMID: 29051764 Free PMC article. Review.
We conclude that induction of polyfunctional CD4(+) T cells is certainly not sufficient and may not even be necessary to mediate protection and suggest that other functional attributes, such as additional effector functions, T cell differentiation state, tissue homing potential, …
We conclude that induction of polyfunctional CD4(+) T cells is certainly not sufficient and may not even be necessary to mediate protection …
Reconstitution of hepatitis C virus-specific T-cellmediated immunity after liver transplantation.
Weston SJ, Leistikow RL, Reddy KR, Torres M, Wertheimer AM, Lewinsohn DM, Chou S, Davey MP, Corless C, O'Farrelly C, Nelson DR, Rosen HR. Weston SJ, et al. Among authors: lewinsohn dm. Hepatology. 2005 Jan;41(1):72-81. doi: 10.1002/hep.20507. Hepatology. 2005. PMID: 15619226
After transplantation, virological recurrence is the rule, but the spectrum of histological injury is wide, ranging from the development of allograft cirrhosis within a few years to minimal hepatitis despite long-term follow-up. The immunological correlates of this variabl …
After transplantation, virological recurrence is the rule, but the spectrum of histological injury is wide, ranging from the development of …