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Multicenter Population Pharmacokinetics of Fentanyl in Neonatal Surgical Patients Using Dried Blood Spot Specimen Collection Demonstrates Maturation of Elimination Clearance.
Rzasa Lynn RS, Henthorn TK, Zuk J, Hammer GB, Drover DR, Levy RJ, Maxwell LG, Sadhasivam S, Suresh S, Galinkin JL. Rzasa Lynn RS, et al. Among authors: levy rj. Anesth Analg. 2024 Feb 1;138(2):447-455. doi: 10.1213/ANE.0000000000006808. Epub 2024 Jan 12. Anesth Analg. 2024. PMID: 38215717
A population PK analysis was used to describe fentanyl disposition in term and preterm neonates. Covariates for the model parameters, including body weight, PMA, birth status (preterm or term), and presence of congenital cardiac disease, were assessed in a st …
A population PK analysis was used to describe fentanyl disposition in term and preterm neonates. Covariates for the model parameters, …
Valved Conduits for Right Ventricular Outflow Tract Reconstruction: A Review of Current Technologies and Future Directions.
Singh SK, Faridmoayer E, Vitale N, Woodard E, Xue Y, Abramov A, Levy RJ, Ferrari G. Singh SK, et al. Among authors: levy rj. Pediatr Cardiol. 2023 Dec 2. doi: 10.1007/s00246-023-03346-z. Online ahead of print. Pediatr Cardiol. 2023. PMID: 38041710 Review.
Currently, cryopreserved homografts are often used given their superiority shown in long-term data. Significant limitations remain in the cost and availability of the graft, particularly for smaller sizes. Contegra conduits are available in a variety of sizes. Nonetheless, …
Currently, cryopreserved homografts are often used given their superiority shown in long-term data. Significant limitations remain in …
Propofol toxicity in the developing mouse heart mitochondria.
Barajas MB, Brunner SD, Wang A, Griffiths KK, Levy RJ. Barajas MB, et al. Among authors: levy rj. Pediatr Res. 2022 Nov;92(5):1341-1349. doi: 10.1038/s41390-022-01985-1. Epub 2022 Feb 16. Pediatr Res. 2022. PMID: 35173299 Free PMC article.
BACKGROUND: Propofol infusion syndrome (PRIS) is a potentially lethal consequence of long-term propofol administration. Children are vulnerable and cardiac involvement is often prominent and associated with mortality. ...
BACKGROUND: Propofol infusion syndrome (PRIS) is a potentially lethal consequence of long-term propofol administration. Children are …
Noncalcific Mechanisms of Bioprosthetic Structural Valve Degeneration.
Marro M, Kossar AP, Xue Y, Frasca A, Levy RJ, Ferrari G. Marro M, et al. Among authors: levy rj. J Am Heart Assoc. 2021 Feb 2;10(3):e018921. doi: 10.1161/JAHA.120.018921. Epub 2021 Jan 26. J Am Heart Assoc. 2021. PMID: 33494616 Free PMC article. Review.
Bioprosthetic heart valves (BHVs) largely circumvent the need for long-term anticoagulation compared with mechanical valves but are increasingly susceptible to deterioration and reduced durability with reoperation rates of 10% and 30% at 10 and 15 years, respectively. ...
Bioprosthetic heart valves (BHVs) largely circumvent the need for long-term anticoagulation compared with mechanical valves but are i …
A Case of Abulia From Left Middle Cerebral Artery Stroke in an Adolescent Treated Successfully With Short Duration Olanzapine.
Connor AT, Crawford A, Levy RJ, Schneider LM, Hollander SA, Shaw RJ. Connor AT, et al. Among authors: levy rj. Clin Neuropharmacol. 2020 May/Jun;43(3):86-89. doi: 10.1097/WNF.0000000000000389. Clin Neuropharmacol. 2020. PMID: 32384311
There have been reports of poststroke patients with abulia being treated by modulating this dopamine circuitry and in some cases with short-term low-dose olanzapine. CONCLUSION: Further research is needed to develop a better understanding of the pathophysiology of abulia l …
There have been reports of poststroke patients with abulia being treated by modulating this dopamine circuitry and in some cases with short- …
Stent-based delivery of adeno-associated viral vectors with sustained vascular transduction and iNOS-mediated inhibition of in-stent restenosis.
Fishbein I, Guerrero DT, Alferiev IS, Foster JB, Minutolo NG, Chorny M, Monteys AM, Driesbaugh KH, Nagaswami C, Levy RJ. Fishbein I, et al. Among authors: levy rj. Gene Ther. 2017 Nov;24(11):717-726. doi: 10.1038/gt.2017.82. Epub 2017 Aug 23. Gene Ther. 2017. PMID: 28832561 Free PMC article.
Our results: 1) demonstrate the feasibility of reversible immobilization of AAV2 vectors using vector tethering by AAV2-specific Ab appended to the stent surface through covalently attached PrG, 2) show sustained release kinetics of PrG/Ab-immobilized AAV2 vector particles into s …
Our results: 1) demonstrate the feasibility of reversible immobilization of AAV2 vectors using vector tethering by AAV2-specific Ab appended …
Magnetically enhanced cell delivery for accelerating recovery of the endothelium in injured arteries.
Adamo RF, Fishbein I, Zhang K, Wen J, Levy RJ, Alferiev IS, Chorny M. Adamo RF, et al. Among authors: levy rj. J Control Release. 2016 Jan 28;222:169-75. doi: 10.1016/j.jconrel.2015.12.025. Epub 2015 Dec 17. J Control Release. 2016. PMID: 26704936 Free PMC article.
The slow and often incomplete endothelium regrowth after injury is the primary cause of serious short- and long-term complications, including thrombosis, restenosis and neoatherosclerosis. ...
The slow and often incomplete endothelium regrowth after injury is the primary cause of serious short- and long-term complications, i …
Deletion of Rapgef6, a candidate schizophrenia susceptibility gene, disrupts amygdala function in mice.
Levy RJ, Kvajo M, Li Y, Tsvetkov E, Dong W, Yoshikawa Y, Kataoka T, Bolshakov VY, Karayiorgou M, Gogos JA. Levy RJ, et al. Transl Psychiatry. 2015 Jun 9;5(6):e577. doi: 10.1038/tp.2015.75. Transl Psychiatry. 2015. PMID: 26057047 Free PMC article.
Neural activation measured by cFOS phosphorylation demonstrated a reduction in hippocampal and amygdala activation after fear conditioning, while neural morphology assessment uncovered reduced spine density and primary dendrite number in pyramidal neurons of the CA3 hippocampal r …
Neural activation measured by cFOS phosphorylation demonstrated a reduction in hippocampal and amygdala activation after fear conditioning, …
Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice.
Kvajo M, McKellar H, Drew LJ, Lepagnol-Bestel AM, Xiao L, Levy RJ, Blazeski R, Arguello PA, Lacefield CO, Mason CA, Simonneau M, O'Donnell JM, MacDermott AB, Karayiorgou M, Gogos JA. Kvajo M, et al. Among authors: levy rj. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):E1349-58. doi: 10.1073/pnas.1114113108. Epub 2011 Nov 2. Proc Natl Acad Sci U S A. 2011. PMID: 22049344 Free PMC article.
We uncover widespread and cumulative cytoarchitectural alterations in the dentate gyrus during neonatal and adult neurogenesis, which include errors in axonal targeting and are accompanied by changes in short-term plasticity at the mossy fiber/CA3 circuit. We also provide …
We uncover widespread and cumulative cytoarchitectural alterations in the dentate gyrus during neonatal and adult neurogenesis, which includ …
C1 esterase inhibitor concentrate in 1085 Hereditary Angioedema attacks--final results of the I.M.P.A.C.T.2 study.
Craig TJ, Bewtra AK, Bahna SL, Hurewitz D, Schneider LC, Levy RJ, Moy JN, Offenberger J, Jacobson KW, Yang WH, Eidelman F, Janss G, Packer FR, Rojavin MA, Machnig T, Keinecke HO, Wasserman RL. Craig TJ, et al. Among authors: levy rj. Allergy. 2011 Dec;66(12):1604-11. doi: 10.1111/j.1398-9995.2011.02702.x. Epub 2011 Sep 2. Allergy. 2011. PMID: 21884533 Clinical Trial.
METHODS: I.M.P.A.C.T.2 was an open-label extension study of I.M.P.A.C.T.1 to evaluate the safety and efficacy of long-term treatment with 20 U/kg C1-INH for successive HAE attacks at any body location. ...CONCLUSIONS: A single dose of 20 U/kg C1-INH concentrate is safe and …
METHODS: I.M.P.A.C.T.2 was an open-label extension study of I.M.P.A.C.T.1 to evaluate the safety and efficacy of long-term treatment …
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