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How do we expand the lung donor pool?
Levvey BJ, Snell GI. Levvey BJ, et al. Curr Opin Pulm Med. 2024 Mar 29. doi: 10.1097/MCP.0000000000001076. Online ahead of print. Curr Opin Pulm Med. 2024. PMID: 38546199
Donors beyond age 70 years are providing better than expected long-term outcomes. Hepatitis C PCR positive donor lungs can be safely used if treated postoperatively with appropriate antivirals. ...
Donors beyond age 70 years are providing better than expected long-term outcomes. Hepatitis C PCR positive donor lungs can be safely …
Donation after Brain Death versus Donation after Circulatory Death: Lung Donor Management Issues.
Snell GI, Levvey BJ, Levin K, Paraskeva M, Westall G. Snell GI, et al. Among authors: levvey bj. Semin Respir Crit Care Med. 2018 Apr;39(2):138-147. doi: 10.1055/s-0037-1615820. Epub 2018 Mar 26. Semin Respir Crit Care Med. 2018. PMID: 29579767 Review.
There are important differences in the public's understanding, legal and consent processes, intensive care unit strategies, lung pathophysiology, logistics, and potential-to-actual donor conversion rates between DBD and DCD. Notwithstanding, the short- and long-term outcom …
There are important differences in the public's understanding, legal and consent processes, intensive care unit strategies, lung pathophysio …
Continued Successful Evolution of Extended Criteria Donor Lungs for Transplantation.
Kotecha S, Hobson J, Fuller J, Paul E, Levvey BJ, Whitford H, Paraskeva M, McGiffin D, Snell GI, Westall GP. Kotecha S, et al. Among authors: levvey bj. Ann Thorac Surg. 2017 Nov;104(5):1702-1709. doi: 10.1016/j.athoracsur.2017.05.042. Epub 2017 Sep 28. Ann Thorac Surg. 2017. PMID: 28964417
There was no correlation between donor score and any of the recipient outcomes, and excellent short-term and longer-term survival was achieved. CONCLUSIONS: Future studies examining lung transplantation outcomes with EVLP must consider the excellent results that can …
There was no correlation between donor score and any of the recipient outcomes, and excellent short-term and longer-term survi …
Long-term successful outcomes from kidney transplantation after lung and heart-lung transplantation.
Otani S, Levvey BJ, Westall GP, Paraskeva M, Whitford H, Williams T, McGiffin DC, Walker R, Menahem S, Snell GI. Otani S, et al. Among authors: levvey bj. Ann Thorac Surg. 2015 Mar;99(3):1032-8. doi: 10.1016/j.athoracsur.2014.11.023. Epub 2015 Jan 23. Ann Thorac Surg. 2015. PMID: 25624053
By contrast, late living related kidney Tx after lung Tx is associated with excellent long-term survival and acceptable kidney and lung allograft function....
By contrast, late living related kidney Tx after lung Tx is associated with excellent long-term survival and acceptable kidney and lu …
Lessons and insights from ABO-incompatible lung transplantation.
Snell GI, Holmes M, Levvey BJ, Shipp A, Robertson C, Westall GP, Cohney S. Snell GI, et al. Among authors: levvey bj. Am J Transplant. 2013 May;13(5):1350-3. doi: 10.1111/ajt.12185. Epub 2013 Mar 6. Am J Transplant. 2013. PMID: 23465218 Free article.
It is apparent that ABOi lung transplantation can result in surprisingly successful long-term outcomes. Low pretransplant antibody titers likely aid this and, in pediatric neonatal or infant cases, this may not be uncommon. ...Understanding the monitoring, prevention and t …
It is apparent that ABOi lung transplantation can result in surprisingly successful long-term outcomes. Low pretransplant antibody ti …
Cytomegalovirus replication within the lung allograft is associated with bronchiolitis obliterans syndrome.
Paraskeva M, Bailey M, Levvey BJ, Griffiths AP, Kotsimbos TC, Williams TP, Snell G, Westall G. Paraskeva M, et al. Among authors: levvey bj. Am J Transplant. 2011 Oct;11(10):2190-6. doi: 10.1111/j.1600-6143.2011.03663.x. Epub 2011 Jul 27. Am J Transplant. 2011. PMID: 21794087 Free article.
As antiviral prophylaxis adequately suppresses CMV longer prophylactic strategies may improve long-term outcome in lung transplantation....
As antiviral prophylaxis adequately suppresses CMV longer prophylactic strategies may improve long-term outcome in lung transplantati …
Thoracic organ transplantation from donation-after-cardiac-death donors.
Snell GI, Levvey BJ. Snell GI, et al. Among authors: levvey bj. Transplantation. 2009 Jul 27;88(2):147-8. doi: 10.1097/TP.0b013e3181abbdcb. Transplantation. 2009. PMID: 19623007
Considering this, if we are to avoid confusing the lay and medical public, perhaps the better term is donation-after-cardiocirculatory death....
Considering this, if we are to avoid confusing the lay and medical public, perhaps the better term is donation-after-cardiocirculator …
Preliminary report of the safety and efficacy of hyperbaric oxygen therapy for specific complications of lung transplantation.
Higuchi T, Oto T, Millar IL, Levvey BJ, Williams TJ, Snell GI. Higuchi T, et al. Among authors: levvey bj. J Heart Lung Transplant. 2006 Nov;25(11):1302-9. doi: 10.1016/j.healun.2006.08.006. Epub 2006 Oct 11. J Heart Lung Transplant. 2006. PMID: 17097493
Five patients had complete resolution of these life-threatening complications. Long-term survival and graft function were excellent, although graft function temporarily fell. ...
Five patients had complete resolution of these life-threatening complications. Long-term survival and graft function were excellent, …
Everolimus alters the bronchoalveolar lavage and endobronchial biopsy immunologic profile post-human lung transplantation.
Snell GI, Levvey BJ, Zheng L, Bailey M, Orsida B, Law L, Whitford HM, Kotsimbos TC, Williams TJ. Snell GI, et al. Among authors: levvey bj. Am J Transplant. 2005 Jun;5(6):1446-51. doi: 10.1111/j.1600-6143.2005.00863.x. Am J Transplant. 2005. PMID: 15888053 Free article. Clinical Trial.
Everolimus has recently shown promise in terms of short- and long-term clinical lung transplant outcomes. This study aims to determine the altered lung allograft cellular and cytokine mileau when everolimus is substituted for azathioprine (AZA). ...
Everolimus has recently shown promise in terms of short- and long-term clinical lung transplant outcomes. This study aims to determin …
Sirolimus allows renal recovery in lung and heart transplant recipients with chronic renal impairment.
Snell GI, Levvey BJ, Chin W, Kotsimbos T, Whitford H, Waters KN, Richardson M, Williams TJ. Snell GI, et al. Among authors: levvey bj. J Heart Lung Transplant. 2002 May;21(5):540-6. doi: 10.1016/s1053-2498(01)00421-1. J Heart Lung Transplant. 2002. PMID: 11983543
RESULTS: After 30 days, 4 of 5 dialyzed patients ceased dialysis and 15 of 20 patients with an elevated serum creatinine (Cr) (mean Cr 0.29 mmol/liter) improved their Cr. The direction of change in Cr at 30 days predicted longer term Cr. The starting Cr did not predict the …
RESULTS: After 30 days, 4 of 5 dialyzed patients ceased dialysis and 15 of 20 patients with an elevated serum creatinine (Cr) (mean Cr 0.29 …