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Antifibrinolytics for heavy menstrual bleeding.
Bryant-Smith AC, Lethaby A, Farquhar C, Hickey M. Bryant-Smith AC, et al. Among authors: lethaby a. Cochrane Database Syst Rev. 2018 Apr 15;4(4):CD000249. doi: 10.1002/14651858.CD000249.pub2. Cochrane Database Syst Rev. 2018. PMID: 29656433 Free PMC article. Review.
Oral treatment for HMB includes antifibrinolytic drugs, which are designed to reduce bleeding by inhibiting clot-dissolving enzymes in the endometrium.Historically, there has been some concern that using the antifibrinolytic tranexamic acid (TXA) for HMB may increase the risk of …
Oral treatment for HMB includes antifibrinolytic drugs, which are designed to reduce bleeding by inhibiting clot-dissolving enzymes in the e …
Preoperative medical therapy before surgery for uterine fibroids.
Lethaby A, Puscasiu L, Vollenhoven B. Lethaby A, et al. Cochrane Database Syst Rev. 2017 Nov 15;11(11):CD000547. doi: 10.1002/14651858.CD000547.pub2. Cochrane Database Syst Rev. 2017. PMID: 29139105 Free PMC article. Review.
Gonadotropin-hormone releasing analogues (GnRHa) induce a state of hypo-oestrogenism that shrinks fibroids , but has unacceptable side effects if used long-term. Other potential hormonal treatments, include progestins and selective progesterone-receptor modulators (SPRMs). …
Gonadotropin-hormone releasing analogues (GnRHa) induce a state of hypo-oestrogenism that shrinks fibroids , but has unacceptable side effec …
Long-term hormone therapy for perimenopausal and postmenopausal women.
Marjoribanks J, Farquhar C, Roberts H, Lethaby A, Lee J. Marjoribanks J, et al. Among authors: lethaby a. Cochrane Database Syst Rev. 2017 Jan 17;1(1):CD004143. doi: 10.1002/14651858.CD004143.pub5. Cochrane Database Syst Rev. 2017. PMID: 28093732 Free PMC article. Review.
This is an updated version of a Cochrane review first published in 2005. OBJECTIVES: To assess effects of long-term HT (at least 1 year's duration) on mortality, cardiovascular outcomes, cancer, gallbladder disease, fracture and cognition in perimenopausal and postmenopaus …
This is an updated version of a Cochrane review first published in 2005. OBJECTIVES: To assess effects of long-term HT (at least 1 ye …
Surgery versus medical therapy for heavy menstrual bleeding.
Marjoribanks J, Lethaby A, Farquhar C. Marjoribanks J, et al. Among authors: lethaby a. Cochrane Database Syst Rev. 2016 Jan 29;2016(1):CD003855. doi: 10.1002/14651858.CD003855.pub3. Cochrane Database Syst Rev. 2016. PMID: 26820670 Free PMC article. Review.
The main limitations were lack of blinding, attrition and imprecision. Moreover, it was difficult to interpret long-term study findings as many women randomised to medical interventions subsequently underwent surgery. ...It was unclear what proportion of women assigned to …
The main limitations were lack of blinding, attrition and imprecision. Moreover, it was difficult to interpret long-term study findin …
Fibroids (uterine myomatosis, leiomyomas).
Lethaby A, Vollenhoven B. Lethaby A, et al. BMJ Clin Evid. 2015 Jun 2;2015:0814. BMJ Clin Evid. 2015. PMID: 26032466 Free PMC article. Review.
Risk factors for fibroids include obesity, having no children, and no long-term use of the oral contraceptive pill. Fibroids tend to shrink or fibrose after the menopause. ...
Risk factors for fibroids include obesity, having no children, and no long-term use of the oral contraceptive pill. Fibroids tend to …
Progesterone or progestogen-releasing intrauterine systems for heavy menstrual bleeding.
Lethaby A, Hussain M, Rishworth JR, Rees MC. Lethaby A, et al. Cochrane Database Syst Rev. 2015 Apr 30;(4):CD002126. doi: 10.1002/14651858.CD002126.pub3. Cochrane Database Syst Rev. 2015. PMID: 25924648 Updated. Review.
It is associated with a greater reduction in HMB, improved quality of life and appears to be more acceptable long term but is associated with more minor adverse effects than oral therapy.When compared to endometrial ablation, it is not clear whether the LNG IUS offers any …
It is associated with a greater reduction in HMB, improved quality of life and appears to be more acceptable long term but is associa …
Pre-operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding.
Tan YH, Lethaby A. Tan YH, et al. Among authors: lethaby a. Cochrane Database Syst Rev. 2013 Nov 15;(11):CD010241. doi: 10.1002/14651858.CD010241.pub2. Cochrane Database Syst Rev. 2013. PMID: 24234875 Review.
AUTHORS' CONCLUSIONS: Low-quality evidence suggests that endometrial thinning with GnRHa and danazol before hysteroscopic surgery improves operating conditions and short-term postoperative outcomes. GnRHa produced slightly more consistent endometrial thinning than was prod …
AUTHORS' CONCLUSIONS: Low-quality evidence suggests that endometrial thinning with GnRHa and danazol before hysteroscopic surgery improves o …
Endometrial resection and ablation techniques for heavy menstrual bleeding.
Lethaby A, Penninx J, Hickey M, Garry R, Marjoribanks J. Lethaby A, et al. Cochrane Database Syst Rev. 2013 Aug 30;(8):CD001501. doi: 10.1002/14651858.CD001501.pub4. Cochrane Database Syst Rev. 2013. PMID: 23990373 Updated. Review.
Endometrial ablation is less invasive and preserves the uterus, although long-term studies have found that the costs of ablative surgery approach the cost of hysterectomy due to the requirement for repeat procedures. ...
Endometrial ablation is less invasive and preserves the uterus, although long-term studies have found that the costs of ablative surg …
36 results