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p17/C18-ceramide-mediated mitophagy is an endogenous neuroprotective response in preclinical and clinical brain injury.
Karakaya E, Oleinik N, Edwards J, Tomberlin J, Barker RB, Berber B, Ericsson M, Alsudani H, Ergul A, Beyaz S, Lemasters JJ, Ogretmen B, Albayram O. Karakaya E, et al. Among authors: lemasters jj. PNAS Nexus. 2024 Feb 7;3(2):pgae018. doi: 10.1093/pnasnexus/pgae018. eCollection 2024 Feb. PNAS Nexus. 2024. PMID: 38328780 Free PMC article.
Repeat concussions (or repetitive mild traumatic brain injury [rmTBI]) are complex pathological processes consisting of a primary insult and long-term secondary complications and are also a prerequisite for chronic traumatic encephalopathy (CTE). ...Using a novel repetitiv …
Repeat concussions (or repetitive mild traumatic brain injury [rmTBI]) are complex pathological processes consisting of a primary insult and …
Glutamate contributes to alcohol hepatotoxicity by enhancing oxidative stress in mitochondria.
Teplova VV, Kruglov AG, Kovalyov LI, Nikiforova AB, Fedotcheva NI, Lemasters JJ. Teplova VV, et al. Among authors: lemasters jj. J Bioenerg Biomembr. 2017 Jun;49(3):253-264. doi: 10.1007/s10863-017-9713-0. Epub 2017 May 6. J Bioenerg Biomembr. 2017. PMID: 28478591 Free PMC article.
The biochemical and proteomic data obtained in the present work suggest that one of the main causes of an increase in ROS generation is enhanced oxidation of glutamate in response to long-term alcohol exposure. In the course of glutamate oxidation, liver mitochondria from …
The biochemical and proteomic data obtained in the present work suggest that one of the main causes of an increase in ROS generation is enha …
2',3'-Cyclic nucleotide 3'-phosphodiesterase as a messenger of protection of the mitochondrial function during melatonin treatment in aging.
Baburina Y, Odinokova I, Azarashvili T, Akatov V, Lemasters JJ, Krestinina O. Baburina Y, et al. Among authors: lemasters jj. Biochim Biophys Acta Biomembr. 2017 Jan;1859(1):94-103. doi: 10.1016/j.bbamem.2016.11.003. Epub 2016 Nov 9. Biochim Biophys Acta Biomembr. 2017. PMID: 27836641 Free PMC article.
The role of melatonin whose level decreases with aging is well understood. In the present study, we demonstrated that long-term treatment of aged rats with melatonin improved the functional state of mitochondria; thus, the Ca(2+) capacity was enhanced and mitochondrial swe …
The role of melatonin whose level decreases with aging is well understood. In the present study, we demonstrated that long-term treat …
Differential effects of rapamycin on rods and cones during light-induced stress in albino mice.
Kunchithapautham K, Coughlin B, Lemasters JJ, Rohrer B. Kunchithapautham K, et al. Among authors: lemasters jj. Invest Ophthalmol Vis Sci. 2011 May 5;52(6):2967-75. doi: 10.1167/iovs.10-6278. Invest Ophthalmol Vis Sci. 2011. PMID: 21273550 Free PMC article.
PURPOSE: Autophagy is a lysosomal machinery-dependent process that catabolizes cellular components/organelles and proteins in an autophagic vacuole (AV)-dependent and -independent manner, respectively. Short-term exposure of the retina to bright light results in shortening …
PURPOSE: Autophagy is a lysosomal machinery-dependent process that catabolizes cellular components/organelles and proteins in an autophagic …
Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition.
Theruvath TP, Zhong Z, Pediaditakis P, Ramshesh VK, Currin RT, Tikunov A, Holmuhamedov E, Lemasters JJ. Theruvath TP, et al. Among authors: lemasters jj. Hepatology. 2008 Jan;47(1):236-46. doi: 10.1002/hep.21912. Hepatology. 2008. PMID: 18023036 Free PMC article.
Additionally, minocycline decreased caspase-3 activity in graft homogenates (P < 0.05). Long-term graft survival was 27% and 33%, respectively, after vehicle and tetracycline treatment, which increased to 60% and 70% after minocycline and NIM811 (P < 0.05). ...

Additionally, minocycline decreased caspase-3 activity in graft homogenates (P < 0.05). Long-term graft survival was 27% and 33%,

…
Selective degradation of mitochondria by mitophagy.
Kim I, Rodriguez-Enriquez S, Lemasters JJ. Kim I, et al. Among authors: lemasters jj. Arch Biochem Biophys. 2007 Jun 15;462(2):245-53. doi: 10.1016/j.abb.2007.03.034. Epub 2007 Apr 12. Arch Biochem Biophys. 2007. PMID: 17475204 Free PMC article. Review.
Autophagic delivery to lysosomes is the major degradative pathway in mitochondrial turnover, and we use the term mitophagy to refer to mitochondrial degradation by autophagy. ...
Autophagic delivery to lysosomes is the major degradative pathway in mitochondrial turnover, and we use the term mitophagy to refer t …
Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging.
Lemasters JJ. Lemasters JJ. Rejuvenation Res. 2005 Spring;8(1):3-5. doi: 10.1089/rej.2005.8.3. Rejuvenation Res. 2005. PMID: 15798367
For this selective autophagy of mitochondria, we propose the term "mitophagy" to emphasize the non-random nature of the process. ...
For this selective autophagy of mitochondria, we propose the term "mitophagy" to emphasize the non-random nature of the process. ...
Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy.
Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE, Brenner DA. Lemasters JJ, et al. Antioxid Redox Signal. 2002 Oct;4(5):769-81. doi: 10.1089/152308602760598918. Antioxid Redox Signal. 2002. PMID: 12470504 Review.
Cellular features of necrosis, apoptosis, and autophagy frequently occur together after death signals and toxic stresses. A new term, necrapoptosis, describes such death processes that begin with a common stress or death signal, progress by shared pathways, but culminate i …
Cellular features of necrosis, apoptosis, and autophagy frequently occur together after death signals and toxic stresses. A new term, …
Alteration in Kupffer cell function after mild hemorrhagic shock.
Hunt JP, Hunter CT, Brownstein MR, Ku J, Roberts L, Currin RT, Lemasters JJ, Baker CC. Hunt JP, et al. Among authors: lemasters jj. Shock. 2001 May;15(5):403-7. doi: 10.1097/00024382-200115050-00012. Shock. 2001. PMID: 11336202
Resuscitation produced immediate recovery of blood pressure and allowed long-term recovery of the animals. Sham animals received anesthesia and monitoring only. ...
Resuscitation produced immediate recovery of blood pressure and allowed long-term recovery of the animals. Sham animals received anes …
Ischemic preconditioning of rat livers against cold storage-reperfusion injury: role of nonparenchymal cells and the phenomenon of heterologous preconditioning.
Arai M, Thurman RG, Lemasters JJ. Arai M, et al. Among authors: lemasters jj. Liver Transpl. 2001 Apr;7(4):292-9. doi: 10.1053/jlts.2001.23080. Liver Transpl. 2001. PMID: 11303287 Free article.
Finally, stored livers were transplanted into nontreated rats. Ischemic preconditioning improved recipient long-term survival after 30 hours of cold ischemic storage in UW solution from 30% to 80% and decreased serum tumor necrosis factor-alpha levels in posthepatic blood …
Finally, stored livers were transplanted into nontreated rats. Ischemic preconditioning improved recipient long-term survival after 3 …
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