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Aerosol-Mediated Non-Viral Lung Gene Therapy: The Potential of Aminoglycoside-Based Cationic Liposomes.
Le Gall T, Berchel M, Davies L, Mottais A, Ghanem R, Fautrel A, Gill D, Hyde S, Lehn P, Lehn JM, Lemiègre L, Benvegnu T, Jaffrès PA, Pitard B, Montier T. Le Gall T, et al. Among authors: lehn p. Pharmaceutics. 2021 Dec 23;14(1):25. doi: 10.3390/pharmaceutics14010025. Pharmaceutics. 2021. PMID: 35056921 Free PMC article.
A single aerosol treatment with one such formulation was found to mediate long-term lung transgene expression, exceeding half the animal's lifetime. ...
A single aerosol treatment with one such formulation was found to mediate long-term lung transgene expression, exceeding half the ani …
Prognostic value of perioperative red blood cell transfusion and anemia on survival and recurrence in oral squamous cell carcinoma.
Spanier G, Böttcher J, Gerken M, Fischer R, Roth G, Lehn P, Klingelhöffer C, Meier JK, Fraccaroli A, Tischer J, Ettl T, Klinkhammer-Schalke M, Reichert TE, Spoerl S. Spanier G, et al. Among authors: lehn p. Oral Oncol. 2020 Aug;107:104773. doi: 10.1016/j.oraloncology.2020.104773. Epub 2020 May 7. Oral Oncol. 2020. PMID: 32388408
CONCLUSION: Preoperative anemia and RBT are significantly associated with impaired long-term outcome of patients suffering from OSCC. Future studies are needed to evaluate differentiated effects of RBTs in anemic and non-anemic OSCC patients and accordingly providing indiv …
CONCLUSION: Preoperative anemia and RBT are significantly associated with impaired long-term outcome of patients suffering from OSCC. …
[Gene therapy of Gaucher's and Fabry's diseases: current status and prospects].
Fabrega S, Lehn P. Fabrega S, et al. Among authors: lehn p. J Soc Biol. 2002;196(2):175-81. J Soc Biol. 2002. PMID: 12360746 Review. French.
Indeed, several recent studies aiming at creating a large in vivo source of alpha-galactosidase have yielded positive long-term results in the Fabry knock-out mouse model....
Indeed, several recent studies aiming at creating a large in vivo source of alpha-galactosidase have yielded positive long-term resul …
Gene therapy using bone marrow transplantation: a 1990 update.
Lehn PM. Lehn PM. Bone Marrow Transplant. 1990 May;5(5):287-93. Bone Marrow Transplant. 1990. PMID: 2190657 Review.
Thus, significant levels of expression of the transgene have been achieved in murine long-term transplant recipients. However, the results obtained so far in large animal studies are still disappointing. ...
Thus, significant levels of expression of the transgene have been achieved in murine long-term transplant recipients. However, the re …
Treatment of severe cytomegalovirus infection with ganciclovir and high-dose intravenous immunoglobulin in patients with allogeneic bone marrow transplants. A pilot study.
Lehn P, Quessar A, Devergie A, Esperou-Bourdeau H, Traineau R, Trédaniel J, Benbunan M, Bussel A, Jolivet I, Mazeron MC, et al. Lehn P, et al. Nouv Rev Fr Hematol (1978). 1990;32(1):17-20. Nouv Rev Fr Hematol (1978). 1990. PMID: 2161510
Out of 18 BMT patients with CMV isolated from BAL in the absence of pulmonary signs, 9 became long-term survivors without any episode of CMV pneumonia and 9 died. However, only 2 patients died because of CMV pneumonia. ...
Out of 18 BMT patients with CMV isolated from BAL in the absence of pulmonary signs, 9 became long-term survivors without any episode …
Long-term study of chimaerism in bone marrow transplantation recipients for severe aplastic anaemia.
Keable H, Bourhis JH, Brison O, Lehn P, Schenmetzler C, Devergie A, Gluckman E. Keable H, et al. Among authors: lehn p. Br J Haematol. 1989 Apr;71(4):525-33. doi: 10.1111/j.1365-2141.1989.tb06313.x. Br J Haematol. 1989. PMID: 2565730
We used minisatellite probes to analyse by DNA fingerprints the long-term engraftment (median 4.3 years, range 1-2) of 21 bone marrow transplantation recipients for severe aplastic anaemia. ...Red cell surface phenotype was also used as marker of engraftment in most cases. …
We used minisatellite probes to analyse by DNA fingerprints the long-term engraftment (median 4.3 years, range 1-2) of 21 bone marrow …
Role of immunosuppressive drugs for prevention of graft-v-host disease after bone marrow transplantation.
Devergie A, Esperou H, Traineau R, Varrin F, Lehn P, Gluckman E. Devergie A, et al. Among authors: lehn p. Nouv Rev Fr Hematol (1978). 1989;31(2):73-5. Nouv Rev Fr Hematol (1978). 1989. PMID: 2671932 Clinical Trial.
These results show that the improvement of methods of prevention of GVHD did not affect significantly long term survival after BMT....
These results show that the improvement of methods of prevention of GVHD did not affect significantly long term survival after BMT... …
Bone marrow transplantation for chronic granulocytic leukemia.
Lehn P, Devergie A, Benbunan M, Lemercier N, Raffoux C, Rabian C, Vilmer E, Azogui O, Irti T, Gluckman E. Lehn P, et al. J Natl Cancer Inst. 1986 Jun;76(6):1301-5. J Natl Cancer Inst. 1986. PMID: 3520072
Thirty-three patients had allogeneic grafts; only 2 received the grafts during blast crisis, and neither is a long-term survivor. Of the 13 patients who had grafts in the accelerated phase, 6 died of complications related to the transplantation, and 1 died after a myelobla …
Thirty-three patients had allogeneic grafts; only 2 received the grafts during blast crisis, and neither is a long-term survivor. Of …