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The persistent inflammation, immunosuppression, and catabolism syndrome 10 years later.
Efron PA, Brakenridge SC, Mohr AM, Barrios EL, Polcz VE, Anton S, Ozrazgat-Baslanti T, Bihorac A, Guirgis F, Loftus TJ, Rosenthal M, Leeuwenburgh C, Mankowski R, Moldawer LL, Moore FA. Efron PA, et al. Among authors: leeuwenburgh c. J Trauma Acute Care Surg. 2023 Nov 1;95(5):790-799. doi: 10.1097/TA.0000000000004087. Epub 2023 Aug 8. J Trauma Acute Care Surg. 2023. PMID: 37561664
In 2012, the University of Florida (UF) Sepsis Critical Illness Research Center (SCIRC) coined the term Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) to provide a mechanistic framework to study CCI in surgical patients. This was followed by a d …
In 2012, the University of Florida (UF) Sepsis Critical Illness Research Center (SCIRC) coined the term Persistent Inflammation, Immu …
The impact of sarcopenia and acute muscle mass loss on long-term outcomes in critically ill patients with intra-abdominal sepsis.
Cox MC, Booth M, Ghita G, Wang Z, Gardner A, Hawkins RB, Darden DB, Leeuwenburgh C, Moldawer LL, Moore FA, Efron PA, Anton S, Brakenridge SC. Cox MC, et al. Among authors: leeuwenburgh c. J Cachexia Sarcopenia Muscle. 2021 Oct;12(5):1203-1213. doi: 10.1002/jcsm.12752. Epub 2021 Jun 30. J Cachexia Sarcopenia Muscle. 2021. PMID: 34196134 Free PMC article.
Measured clinical outcomes included development of chronic critical illness (14 days in intensive care with persistent organ dysfunction), long-term functional status, and 1 year mortality. RESULTS: Among 47 sepsis patients enrolled (mean age 53 14 years), half (n = 23; 49 …
Measured clinical outcomes included development of chronic critical illness (14 days in intensive care with persistent organ dysfunction), l …
Lipid and lipoprotein predictors of functional outcomes and long-term mortality after surgical sepsis.
Guirgis FW, Leeuwenburgh C, Moldawer L, Ghita G, Black LP, Henson M, DeVos E, Holden D, Efron P, Reddy ST, Moore FA. Guirgis FW, et al. Among authors: leeuwenburgh c. Ann Intensive Care. 2021 May 20;11(1):82. doi: 10.1186/s13613-021-00865-x. Ann Intensive Care. 2021. PMID: 34018068 Free PMC article.
Lipid biomarkers including cholesterol are dynamically regulated during sepsis and predict short-term outcomes. In this study, we investigated the predictive ability of lipid biomarkers for physical function and long-term mortality after sepsis. ...
Lipid biomarkers including cholesterol are dynamically regulated during sepsis and predict short-term outcomes. In this study, we inv …
Older Adults Demonstrate Biomarker Evidence of the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) After Sepsis.
Mankowski RT, Anton SD, Ghita GL, Brumback B, Darden DB, Bihorac A, Leeuwenburgh C, Moldawer LL, Efron PA, Brakenridge SC, Moore FA. Mankowski RT, et al. Among authors: leeuwenburgh c. J Gerontol A Biol Sci Med Sci. 2022 Jan 7;77(1):188-196. doi: 10.1093/gerona/glab080. J Gerontol A Biol Sci Med Sci. 2022. PMID: 33721883 Free PMC article.
However, many older survivors develop chronic critical illness (CCI) with poor long-term outcomes. The etiology of CCI is multifactorial and the relative importance remains unclear. ...
However, many older survivors develop chronic critical illness (CCI) with poor long-term outcomes. The etiology of CCI is multifactor …
Septic Stability? Gut Microbiota in Young Adult Mice Maintains Overall Stability After Sepsis Compared to Old Adult Mice.
Mankowski RT, Thomas RM, Darden DB, Gharaibeh RZ, Hawkins RB, Cox MC, Apple C, Nacionales DC, Ungaro RF, Dirain ML, Moore FA, Leeuwenburgh C, Brakenridge SC, Clanton TL, Laitano O, Moldawer LL, Mohr AM, Efron PA. Mankowski RT, et al. Among authors: leeuwenburgh c. Shock. 2021 Apr 1;55(4):519-525. doi: 10.1097/SHK.0000000000001648. Shock. 2021. PMID: 32826817 Free PMC article.
The lack of microbiome stability could contribute to PICS and worse long-term outcomes in older adult sepsis survivors. Further studies are warranted to elucidate mechanistic pathways and potential therapeutics....
The lack of microbiome stability could contribute to PICS and worse long-term outcomes in older adult sepsis survivors. Further studi …
Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival.
Mankowski RT, Anton SD, Ghita GL, Brumback B, Cox MC, Mohr AM, Leeuwenburgh C, Moldawer LL, Efron PA, Brakenridge SC, Moore FA. Mankowski RT, et al. Among authors: leeuwenburgh c. J Am Geriatr Soc. 2020 Sep;68(9):1962-1969. doi: 10.1111/jgs.16435. Epub 2020 Apr 15. J Am Geriatr Soc. 2020. PMID: 32294254 Free PMC article.
OBJECTIVES: Sepsis has been called a "disease of the elderly," and as in-hospital mortality has decreased, more sepsis survivors are progressing into poorly characterized long-term outcomes. The purpose of this study was to describe the current epidemiology of sepsis in ol …
OBJECTIVES: Sepsis has been called a "disease of the elderly," and as in-hospital mortality has decreased, more sepsis survivors are progres …
Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability.
Glynn NW, Gmelin T, Santanasto AJ, Lovato LC, Lange-Maia BS, Nicklas BJ, Fielding RA, Manini TM, Myers VH, de Rekeneire N, Spring BJ, Pahor M, King AC, Rejeski WJ, Newman AB; Lifestyle Interventions and Independence for Elders Study Group. Glynn NW, et al. J Am Geriatr Soc. 2020 Mar;68(3):619-624. doi: 10.1111/jgs.16274. Epub 2019 Dec 22. J Am Geriatr Soc. 2020. PMID: 31867713 Free PMC article. Clinical Trial.
Results of baseline fatigue by intervention interaction was MMD (P = .18) and PMMD (P = .05). CONCLUSION: A long-term moderate intensity PA intervention was particularly effective at preserving mobility in older adults with higher levels of baseline fatigue. ...
Results of baseline fatigue by intervention interaction was MMD (P = .18) and PMMD (P = .05). CONCLUSION: A long-term moderate intens …
Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.
Hollen MK, Stortz JA, Darden D, Dirain ML, Nacionales DC, Hawkins RB, Cox MC, Lopez MC, Rincon JC, Ungaro R, Wang Z, Wu Q, Brumback B, Gauthier ML, Kladde M, Leeuwenburgh C, Segal M, Bihorac A, Brakenridge S, Moore FA, Baker HV, Mohr AM, Moldawer LL, Efron PA. Hollen MK, et al. Among authors: leeuwenburgh c. Crit Care. 2019 Nov 13;23(1):355. doi: 10.1186/s13054-019-2628-x. Crit Care. 2019. PMID: 31722736 Free PMC article.
Central to the host immunologic response to sepsis is the increase in circulating myeloid-derived suppressor cells (MDSCs), which have been demonstrated to be present and independently associated with poor long-term clinical outcomes. MDSCs are plastic cells and potentiall …
Central to the host immunologic response to sepsis is the increase in circulating myeloid-derived suppressor cells (MDSCs), which have been …
Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.
Stortz JA, Hollen MK, Nacionales DC, Horiguchi H, Ungaro R, Dirain ML, Wang Z, Wu Q, Wu KK, Kumar A, Foster TC, Stewart BD, Ross JA, Segal M, Bihorac A, Brakenridge S, Moore FA, Wohlgemuth SE, Leeuwenburgh C, Mohr AM, Moldawer LL, Efron PA. Stortz JA, et al. Among authors: leeuwenburgh c. Crit Care Med. 2019 Nov;47(11):e919-e929. doi: 10.1097/CCM.0000000000003926. Crit Care Med. 2019. PMID: 31389840 Free PMC article.
Furthermore, we aimed to create a model that allows the study of aging on the long-term host response to sepsis. DESIGN: Experimental study. SETTING: Research laboratory. ...
Furthermore, we aimed to create a model that allows the study of aging on the long-term host response to sepsis. DESIGN: Experimental …
Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors.
Custodero C, Wu Q, Ghita GL, Anton SD, Brakenridge SC, Brumback BA, Efron PA, Gardner AK, Leeuwenburgh C, Moldawer LL, Petersen JW, Moore FA, Mankowski RT. Custodero C, et al. Among authors: leeuwenburgh c. Crit Care. 2019 Jun 24;23(1):230. doi: 10.1186/s13054-019-2505-7. Crit Care. 2019. PMID: 31234943 Free PMC article.
BACKGROUND: Sepsis survivors often develop chronic critical illness (CCI) and demonstrate the persistent inflammation, immunosuppression, and catabolism syndrome predisposing them to long-term functional limitations and higher mortality. There is a need to identify biomark …
BACKGROUND: Sepsis survivors often develop chronic critical illness (CCI) and demonstrate the persistent inflammation, immunosuppression, an …
53 results