Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum.
Kümpornsin K, Kochakarn T, Yeo T, Okombo J, Luth MR, Hoshizaki J, Rawat M, Pearson RD, Schindler KA, Mok S, Park H, Uhlemann AC, Jana GP, Maity BC, Laleu B, Chenu E, Duffy J, Moliner Cubel S, Franco V, Gomez-Lorenzo MG, Gamo FJ, Winzeler EA, Fidock DA, Chookajorn T, Lee MCS.
Kümpornsin K, et al. Among authors: lee mcs.
Nat Commun. 2023 May 27;14(1):3059. doi: 10.1038/s41467-023-38774-1.
Nat Commun. 2023.
PMID: 37244916
Free PMC article.
We validate mutations in a previously uncharacterised gene, PF3D7_1359900, which we term quinoxaline resistance protein (QRP1), as causal for resistance to MMV665794 and a panel of quinoxaline analogues. ...
We validate mutations in a previously uncharacterised gene, PF3D7_1359900, which we term quinoxaline resistance protein (QRP1), as ca …