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Long-term safety and efficacy of tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study.
Lancet Respir Med. 2021 Jul;9(7):733-746. doi: 10.1016/S2213-2600(20)30510-5. Epub 2021 Feb 10.
Lancet Respir Med. 2021.
PMID: 33581080
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability, and efficacy of tezacaftor-ivacaftor in participants aged 12 years or older with cystic fibrosis who were homozygous or heterozygous for t …
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability …
Long-term effect of insulin treatment in cystic fibrosis-related diabetes.
Mohan K, Israel KL, Miller H, Grainger R, Ledson MJ, Walshaw MJ.
Mohan K, et al. Among authors: ledson mj.
Respiration. 2008;76(2):181-6. doi: 10.1159/000110206. Epub 2007 Oct 25.
Respiration. 2008.
PMID: 17960051
BACKGROUND: Although insulin treatment confers short-term benefit in cystic fibrosis-related diabetes (CFRD), few studies have compared its long-term effect on the clinical outcome. OBJECTIVES: In this study, we aimed to investigate the long-term impact of in …
BACKGROUND: Although insulin treatment confers short-term benefit in cystic fibrosis-related diabetes (CFRD), few studies have compar …
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Renal impairment in cystic fibrosis patients due to repeated intravenous aminoglycoside use.
Al-Aloul M, Miller H, Alapati S, Stockton PA, Ledson MJ, Walshaw MJ.
Al-Aloul M, et al. Among authors: ledson mj.
Pediatr Pulmonol. 2005 Jan;39(1):15-20. doi: 10.1002/ppul.20138.
Pediatr Pulmonol. 2005.
PMID: 15521084
Clinical Trial.
Although there are reports of cases of acute renal failure occurring in cystic fibrosis (CF) patients, usually in association with the use of nephrotoxic antibiotic therapy, there have been no studies of renal function in this patient group. We hypothesized that long-term …
Although there are reports of cases of acute renal failure occurring in cystic fibrosis (CF) patients, usually in association with the use o …
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