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Long-term safety and efficacy of tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study.
Flume PA, Biner RF, Downey DG, Brown C, Jain M, Fischer R, De Boeck K, Sawicki GS, Chang P, Paz-Diaz H, Rubin JL, Yang Y, Hu X, Pasta DJ, Millar SJ, Campbell D, Wang X, Ahluwalia N, Owen CA, Wainwright CE; VX14-661-110 study group. Flume PA, et al. Lancet Respir Med. 2021 Jul;9(7):733-746. doi: 10.1016/S2213-2600(20)30510-5. Epub 2021 Feb 10. Lancet Respir Med. 2021. PMID: 33581080
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability, and efficacy of tezacaftor-ivacaftor in participants aged 12 years or older with cystic fibrosis who were homozygous or heterozygous for t …
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability …
The UK Lung Cancer Screening Trial: a pilot randomised controlled trial of low-dose computed tomography screening for the early detection of lung cancer.
Field JK, Duffy SW, Baldwin DR, Brain KE, Devaraj A, Eisen T, Green BA, Holemans JA, Kavanagh T, Kerr KM, Ledson M, Lifford KJ, McRonald FE, Nair A, Page RD, Parmar MK, Rintoul RC, Screaton N, Wald NJ, Weller D, Whynes DK, Williamson PR, Yadegarfar G, Hansell DM. Field JK, et al. Among authors: ledson m. Health Technol Assess. 2016 May;20(40):1-146. doi: 10.3310/hta20400. Health Technol Assess. 2016. PMID: 27224642 Free PMC article. Clinical Trial.
Lung cancer was more common in the lowest socioeconomic group. Short-term adverse psychosocial consequences were observed in participants who were randomised to the intervention arm and in those who had a major lung abnormality detected, but these differences were modest a …
Lung cancer was more common in the lowest socioeconomic group. Short-term adverse psychosocial consequences were observed in particip …
Long-term effect of insulin treatment in cystic fibrosis-related diabetes.
Mohan K, Israel KL, Miller H, Grainger R, Ledson MJ, Walshaw MJ. Mohan K, et al. Among authors: ledson mj. Respiration. 2008;76(2):181-6. doi: 10.1159/000110206. Epub 2007 Oct 25. Respiration. 2008. PMID: 17960051
BACKGROUND: Although insulin treatment confers short-term benefit in cystic fibrosis-related diabetes (CFRD), few studies have compared its long-term effect on the clinical outcome. OBJECTIVES: In this study, we aimed to investigate the long-term impact of in …
BACKGROUND: Although insulin treatment confers short-term benefit in cystic fibrosis-related diabetes (CFRD), few studies have compar …
Comparison of methods of assessment of renal function in cystic fibrosis (CF) patients.
Al-Aloul M, Jackson M, Bell G, Ledson M, Walshaw M. Al-Aloul M, et al. Among authors: ledson m. J Cyst Fibros. 2007 Jan;6(1):41-7. doi: 10.1016/j.jcf.2006.05.004. Epub 2006 Jun 27. J Cyst Fibros. 2007. PMID: 16807143 Free article.
Renal failure is increasingly being recognised in CF patients, usually as a consequence of long-term nephrotoxic therapy. There is a need for a simple method of assessment of renal function in this patient group. ...
Renal failure is increasingly being recognised in CF patients, usually as a consequence of long-term nephrotoxic therapy. There is a …
Renal impairment in cystic fibrosis patients due to repeated intravenous aminoglycoside use.
Al-Aloul M, Miller H, Alapati S, Stockton PA, Ledson MJ, Walshaw MJ. Al-Aloul M, et al. Among authors: ledson mj. Pediatr Pulmonol. 2005 Jan;39(1):15-20. doi: 10.1002/ppul.20138. Pediatr Pulmonol. 2005. PMID: 15521084 Clinical Trial.
Although there are reports of cases of acute renal failure occurring in cystic fibrosis (CF) patients, usually in association with the use of nephrotoxic antibiotic therapy, there have been no studies of renal function in this patient group. We hypothesized that long-term …
Although there are reports of cases of acute renal failure occurring in cystic fibrosis (CF) patients, usually in association with the use o …