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Factors contributing to U.S. parents' decisions to administer melatonin to children.
Hartstein LE, Garrison MM, Lewin D, Boergers J, Hiraki BK, Harsh JR, LeBourgeois MK. Hartstein LE, et al. Sleep Med. 2024 Feb;114:49-54. doi: 10.1016/j.sleep.2023.12.018. Epub 2023 Dec 22. Sleep Med. 2024. PMID: 38154149
OBJECTIVE: Pediatric melatonin use is increasingly prevalent in the U.S. despite limited research on its efficacy and long-term safety. The current study investigated factors contributing to parents' decisions whether to give children melatonin. ...
OBJECTIVE: Pediatric melatonin use is increasingly prevalent in the U.S. despite limited research on its efficacy and long-term safet …
Impact of the COVID-19 pandemic on children's sleep habits: an ECHO study.
Lucchini M, Bekelman TA, Li M, Knapp EA, Dong Y, Ballard S, Deoni S, Dunlop AL, Elliott AJ, Ferrara A, Friedman C, Galarce M, Gilbert-Diamond D, Glueck D, Hedderson M, Hockett CW, Karagas MR, LeBourgeois MK, Margolis A, McDonald J, Ngai P, Pellerite M, Sauder K, Ma T, Dabelea D; Environmental influences on Child Health Outcomes. Lucchini M, et al. Pediatr Res. 2023 Feb;93(3):586-594. doi: 10.1038/s41390-022-02309-z. Epub 2022 Oct 4. Pediatr Res. 2023. PMID: 36195633 Free PMC article.
This is one of the first study on this topic in the US, including prospective pre-pandemic qualitative and quantitative data on sleep habits. Our findings highlight the pandemic long-term impact on childhood sleep. Results warrants further investigations on implications fo …
This is one of the first study on this topic in the US, including prospective pre-pandemic qualitative and quantitative data on sleep habits …
Rapid Improvement after Starting Elexacaftor-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and Advanced Pulmonary Disease.
Burgel PR, Durieu I, Chiron R, Ramel S, Danner-Boucher I, Prevotat A, Grenet D, Marguet C, Reynaud-Gaubert M, Macey J, Mely L, Fanton A, Quetant S, Lemonnier L, Paillasseur JL, Da Silva J, Martin C; French Cystic Fibrosis Reference Network Study Group. Burgel PR, et al. Am J Respir Crit Care Med. 2021 Jul 1;204(1):64-73. doi: 10.1164/rccm.202011-4153OC. Am J Respir Crit Care Med. 2021. PMID: 33600738

The mean (95% confidence interval) absolute increase in the ppFEV(1) was +15.1 (+13.8 to +16.4; P < 0.0001), and the mean (95% confidence interval) in weight was +4.2 kg (+3.9 to +4.6; P < 0.0001). The number of patients requiring long-term oxygen, noninvasive ventil

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The mean (95% confidence interval) absolute increase in the ppFEV(1) was +15.1 (+13.8 to +16.4; P < 0.0001), and the mean (95% confidence

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Is the raised volume rapid thoracic compression technique ready for use in clinical trials in infants with cystic fibrosis?
Matecki S, Kent L, de Boeck K, Le Bourgeois M, Zielen S, Braggion C, Arets HG, Bradley J, Davis S, Sermet I, Reix P; respiratory function group of the European Cystic Fibrosis Society Clinical Trial Network. Matecki S, et al. Among authors: le bourgeois m. J Cyst Fibros. 2016 Jan;15(1):10-20. doi: 10.1016/j.jcf.2015.03.015. Epub 2015 Apr 15. J Cyst Fibros. 2016. PMID: 25890589 Free article. Review.
We advise its use currently in phase I/II trials and as a secondary endpoint in phase III studies. We emphasise the need for (1) more short-term variability and longitudinal 'natural history' studies, and (2) robust reference values for commercially available devices....
We advise its use currently in phase I/II trials and as a secondary endpoint in phase III studies. We emphasise the need for (1) more short- …
Technical and practical issues for tidal breathing measurements of nasal nitric oxide in children.
Beydon N, Chambellan A, Alberti C, de Blic J, Clément A, Escudier E, Le Bourgeois M. Beydon N, et al. Among authors: le bourgeois m. Pediatr Pulmonol. 2015 Dec;50(12):1374-82. doi: 10.1002/ppul.23167. Epub 2015 Mar 2. Pediatr Pulmonol. 2015. PMID: 25731630
TB-nNO could differ between the two nostrils by more than 10% (or 10 ppb when nNO absolute value lower 100 ppb) in 32-43% of the tested children, according to the different tidal breathing values, and was reproducible in the long term but influenced by ambient NO. Despite …
TB-nNO could differ between the two nostrils by more than 10% (or 10 ppb when nNO absolute value lower 100 ppb) in 32-43% of the tested chil …
Asphyxiating thoracic dysplasia: clinical and molecular review of 39 families.
Baujat G, Huber C, El Hokayem J, Caumes R, Do Ngoc Thanh C, David A, Delezoide AL, Dieux-Coeslier A, Estournet B, Francannet C, Kayirangwa H, Lacaille F, Le Bourgeois M, Martinovic J, Salomon R, Sigaudy S, Malan V, Munnich A, Le Merrer M, Le Quan Sang KH, Cormier-Daire V. Baujat G, et al. Among authors: le bourgeois m. J Med Genet. 2013 Feb;50(2):91-8. doi: 10.1136/jmedgenet-2012-101282. J Med Genet. 2013. PMID: 23339108
The clinical and molecular heterogeneity leads to difficulties in the evaluation of the long-term prognosis. METHODS: We investigated 53 ATD cases (23 living cases and 30 fetuses) from 39 families. ...The presence of only one mutation in six families and the exclusion of t …
The clinical and molecular heterogeneity leads to difficulties in the evaluation of the long-term prognosis. METHODS: We investigated …
The lung is involved in juvenile dermatomyositis.
Pouessel G, Deschildre A, Le Bourgeois M, Cuisset JM, Catteau B, Karila C, Nève V, Thumerelle C, Quartier P, Tillie-Leblond I. Pouessel G, et al. Among authors: le bourgeois m. Pediatr Pulmonol. 2013 Oct;48(10):1016-25. doi: 10.1002/ppul.22742. Epub 2012 Dec 31. Pediatr Pulmonol. 2013. PMID: 23281200
Longitudinal studies are needed to assess pediatric characteristics, long-term outcomes, and responses to treatment taking into account the risk-benefit ratio....
Longitudinal studies are needed to assess pediatric characteristics, long-term outcomes, and responses to treatment taking into accou …
Respiratory outcome in children with scimitar syndrome.
Chemin A, Bonnet D, Le Bourgeois M, Levy M, Delacourt C; Respiratory Outcome in Scimitar Syndrome Collaborators. Chemin A, et al. Among authors: le bourgeois m. J Pediatr. 2013 Feb;162(2):275-9.e1. doi: 10.1016/j.jpeds.2012.07.066. Epub 2012 Sep 14. J Pediatr. 2013. PMID: 22985724
Pulmonary hypoplasia appears as an independent marker of long-term severity in these patients....
Pulmonary hypoplasia appears as an independent marker of long-term severity in these patients....
Familial interstitial disease with I73T mutation: A mid- and long-term study.
Abou Taam R, Jaubert F, Emond S, Le Bourgeois M, Epaud R, Karila C, Feldmann D, Scheinmann P, de Blic J. Abou Taam R, et al. Among authors: le bourgeois m. Pediatr Pulmonol. 2009 Feb;44(2):167-75. doi: 10.1002/ppul.20970. Pediatr Pulmonol. 2009. PMID: 19148933
OBJECTIVES: To describe the long-term course and the management in children of chronic interstitial lung disease associated with I73T mutation. ...
OBJECTIVES: To describe the long-term course and the management in children of chronic interstitial lung disease associated with I73T …
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