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Newborn screening alone insufficient to improve pulmonary outcomes for cystic fibrosis.
Barreda CB, Farrell PM, Laxova A, Eickhoff JC, Braun AT, Coller RJ, Rock MJ. Barreda CB, et al. Among authors: laxova a. J Cyst Fibros. 2021 May;20(3):492-498. doi: 10.1016/j.jcf.2020.06.002. Epub 2020 Jun 13. J Cyst Fibros. 2021. PMID: 32546430 Free PMC article.
Because the evaluations of these subjects by protocol ended in 2012, our objective was to assess long-term pulmonary and mortality outcomes. METHODS: Retrospective analysis of the RCT cohort utilized longitudinal outcome measures obtained from the Cystic Fibrosis Foundatio …
Because the evaluations of these subjects by protocol ended in 2012, our objective was to assess long-term pulmonary and mortality ou …
Long-term follow-up of cystic fibrosis newborn screening: psychosocial functioning of adolescents and young adults.
Tluczek A, Laxova A, Grieve A, Heun A, Brown RL, Rock MJ, Gershan WM, Farrell PM. Tluczek A, et al. Among authors: laxova a. J Cyst Fibros. 2014 Mar;13(2):227-34. doi: 10.1016/j.jcf.2013.10.001. Epub 2013 Oct 21. J Cyst Fibros. 2014. PMID: 24157354 Free PMC article.
BACKGROUND: Long-term psychosocial outcomes of cystic fibrosis (CF) patients diagnosed through newborn screening remain unknown. ...
BACKGROUND: Long-term psychosocial outcomes of cystic fibrosis (CF) patients diagnosed through newborn screening remain unknown. ...
Evidence on improved outcomes with early diagnosis of cystic fibrosis through neonatal screening: enough is enough!
Farrell PM, Lai HJ, Li Z, Kosorok MR, Laxova A, Green CG, Collins J, Hoffman G, Laessig R, Rock MJ, Splaingard ML. Farrell PM, et al. Among authors: laxova a. J Pediatr. 2005 Sep;147(3 Suppl):S30-6. doi: 10.1016/j.jpeds.2005.08.012. J Pediatr. 2005. PMID: 16202779 Clinical Trial.
Follow-up evaluation for 16 years showed that height and weight differences persisted long term. Although screened patients had better chest x-ray scores at diagnosis, our trial suggests that the effects of confounders such as Pseudomonas aeruginosa infections led to deter …
Follow-up evaluation for 16 years showed that height and weight differences persisted long term. Although screened patients had bette …
Respiratory infections with Pseudomonas aeruginosa in children with cystic fibrosis: early detection by serology and assessment of risk factors.
West SE, Zeng L, Lee BL, Kosorok MR, Laxova A, Rock MJ, Splaingard MJ, Farrell PM. West SE, et al. Among authors: laxova a. JAMA. 2002 Jun 12;287(22):2958-67. doi: 10.1001/jama.287.22.2958. JAMA. 2002. PMID: 12052125
Once P aeruginosa infection is established, eradication may be impossible, and progressive lung disease often aggravates morbidity and mortality risks. The ability to diagnose CF by genetic testing at birth makes it possible to determine the temporal sequence of events tha …
Once P aeruginosa infection is established, eradication may be impossible, and progressive lung disease often aggravates morbidity and morta …
Wisconsin cystic fibrosis chest radiograph scoring system: validation and standardization for application to longitudinal studies.
Koscik RE, Kosorok MR, Farrell PM, Collins J, Peters ME, Laxova A, Green CG, Zeng L, Rusakow LS, Hardie RC, Campbell PW, Gurney JW. Koscik RE, et al. Among authors: laxova a. Pediatr Pulmonol. 2000 Jun;29(6):457-67. doi: 10.1002/(sici)1099-0496(200006)29:6<457::aid-ppul8>3.0.co;2-9. Pediatr Pulmonol. 2000. PMID: 10821728
Quantitative chest radiology applied to children with cystic fibrosis studied long-term in longitudinal research projects requires the careful use of sensitive scoring methods and careful selection and training of multiple raters. ...
Quantitative chest radiology applied to children with cystic fibrosis studied long-term in longitudinal research projects requires th …
Cystic fibrosis newborn screening: impact on reproductive behavior and implications for genetic counseling.
Mischler EH, Wilfond BS, Fost N, Laxova A, Reiser C, Sauer CM, Makholm LM, Shen G, Feenan L, McCarthy C, Farrell PM. Mischler EH, et al. Among authors: laxova a. Pediatrics. 1998 Jul;102(1 Pt 1):44-52. doi: 10.1542/peds.102.1.44. Pediatrics. 1998. PMID: 9651412 Clinical Trial.
There were 3 pregnancies with CF detected, all of which were carried to term. In the false-positive groups, >95% of families initially understood that their child definitely did not have CF. ...
There were 3 pregnancies with CF detected, all of which were carried to term. In the false-positive groups, >95% of families initi …
Nutritional assessment of infants with cystic fibrosis diagnosed through screening.
Mischler EH, Marcus MS, Sondel SA, Laxova A, Carey P, Langhough R, Farrell PM. Mischler EH, et al. Among authors: laxova a. Pediatr Pulmonol Suppl. 1991;7:56-63. doi: 10.1002/ppul.1950110712. Pediatr Pulmonol Suppl. 1991. PMID: 1782132 Clinical Trial.
Careful attention should be paid to vitamin E and essential fatty acid status in all CF infants. The numbers in this study are small and the long-term consequences of early nutritional intervention await the conclusion of the randomized, controlled study on-going in Wiscon …
Careful attention should be paid to vitamin E and essential fatty acid status in all CF infants. The numbers in this study are small and the …