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Phenytoin Reduces Activity of Cardiac Ryanodine Receptor 2; A Potential Mechanism for Its Cardioprotective Action.
Ashna A, van Helden DF, Dos Remedios C, Molenaar P, Laver DR. Ashna A, et al. Among authors: laver dr. Mol Pharmacol. 2020 Apr;97(4):250-258. doi: 10.1124/mol.119.117721. Epub 2020 Feb 3. Mol Pharmacol. 2020. PMID: 32015008
Unfortunately, dantrolene is hepatotoxic and unsuitable for chronic long-term administration. Because phenytoin and dantrolene belong to the hydantoin class of compounds, we test the hypothesis that dantrolene and phenytoin have similar inhibitory effects on RyR2 using a s …
Unfortunately, dantrolene is hepatotoxic and unsuitable for chronic long-term administration. Because phenytoin and dantrolene belong …