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Opportunistic dried blood spot sampling validates and optimizes a pediatric population pharmacokinetic model of metronidazole.
Randell RL, Balevic SJ, Greenberg RG, Cohen-Wolkowiez M, Thompson EJ, Venkatachalam S, Smith MJ, Bendel C, Bliss JM, Chaaban H, Chhabra R, Dammann CEL, Downey LC, Hornik C, Hussain N, Laughon MM, Lavery A, Moya F, Saxonhouse M, Sokol GM, Trembath A, Weitkamp J-H, Hornik CP; Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee. Randell RL, et al. Among authors: laughon mm. Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0153323. doi: 10.1128/aac.01533-23. Epub 2024 Mar 14. Antimicrob Agents Chemother. 2024. PMID: 38477706 Free PMC article.
Using the resulting predictive equation, we estimated plasma metronidazole concentrations (ePlasma) from 399 DBS collected from 122 preterm and term infants [mean (SD): post natal age 16.7 (15.8) days, GA 31.4 (5.1) weeks] from the Antibiotic Safety in Infants with Complic …
Using the resulting predictive equation, we estimated plasma metronidazole concentrations (ePlasma) from 399 DBS collected from 122 preterm …
Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study.
Green CE, Tyson JE, Heyne RJ, Hintz SR, Vohr BR, Bann CM, Das A, Bell EF, Debsareea SB, Stephens E, Gantz MG, Petrie Huitema CM, Johnson KJ, Watterberg KL, Mosquera R, Peralta-Carcelen M, Wilson-Costello DE, Colaizy TT, Maitre NL, Merhar SL, Adams-Chapman I, Fuller J, Hartley-McAndrew ME, Malcolm WF, Winter S, Duncan AF, Myer GJ, Kicklighter SD, Wyckoff MH, DeMauro SB, Hibbs AM, Stoll BJ, Carlo WA, Van Meurs KP, Rysavy MA, Patel RM, Sánchez PJ, Laptook AR, Cotten CM, D'Angio CT, Walsh MC; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Green CE, et al. J Perinatol. 2023 Nov;43(11):1398-1405. doi: 10.1038/s41372-023-01729-x. Epub 2023 Aug 4. J Perinatol. 2023. PMID: 37542155 Free PMC article.
CONCLUSION: Impairment rates among EP infants appear to be substantially underestimated from Bayley III norms. These rates may be best assessed by comparison with healthy term infants followed with minimal attrition from birth in the same centers. GOV ID: Term …
CONCLUSION: Impairment rates among EP infants appear to be substantially underestimated from Bayley III norms. These rates may be best asses …
Placental transfusion and short-term outcomes among extremely preterm infants.
Kumbhat N, Eggleston B, Davis AS, Van Meurs KP, DeMauro SB, Foglia EE, Lakshminrusimha S, Walsh MC, Watterberg KL, Wyckoff MH, Das A, Handley SC; Generic Database Subcommittee of the NICHD Neonatal Research Network; undefined. Kumbhat N, et al. Arch Dis Child Fetal Neonatal Ed. 2021 Jan;106(1):62-68. doi: 10.1136/archdischild-2019-318710. Epub 2020 Jul 30. Arch Dis Child Fetal Neonatal Ed. 2021. PMID: 32732380 Free PMC article.
OBJECTIVE: To compare short-term outcomes after placental transfusion (delayed cord clamping (DCC) or umbilical cord milking (UCM)) versus immediate cord clamping among extremely preterm infants. ...
OBJECTIVE: To compare short-term outcomes after placental transfusion (delayed cord clamping (DCC) or umbilical cord milking (UCM)) v …
Rifampin Pharmacokinetics and Safety in Preterm and Term Infants.
Smith PB, Cotten CM, Hudak ML, Sullivan JE, Poindexter BB, Cohen-Wolkowiez M, Boakye-Agyeman F, Lewandowski A, Anand R, Benjamin DK Jr, Laughon MM; Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee. Smith PB, et al. Among authors: laughon mm. Antimicrob Agents Chemother. 2019 May 24;63(6):e00284-19. doi: 10.1128/AAC.00284-19. Print 2019 Jun. Antimicrob Agents Chemother. 2019. PMID: 30910891 Free PMC article. Clinical Trial.
Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age.
Sarkar S, Shankaran S, Barks J, Do BT, Laptook AR, Das A, Ambalavanan N, Van Meurs KP, Bell EF, Sanchez PJ, Hintz SR, Wyckoff MH, Stoll BJ, Carlo WA; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Sarkar S, et al. J Pediatr. 2018 Apr;195:59-65.e3. doi: 10.1016/j.jpeds.2017.12.010. Epub 2018 Feb 2. J Pediatr. 2018. PMID: 29398046 Free PMC article.
Antecedents and Outcomes of Abnormal Cranial Imaging in Moderately Preterm Infants.
Natarajan G, Shankaran S, Saha S, Laptook A, Das A, Higgins R, Stoll BJ, Bell EF, Carlo WA, D'Angio C, DeMauro SB, Sanchez P, Van Meurs K, Vohr B, Newman N, Hale E, Walsh M; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Natarajan G, et al. J Pediatr. 2018 Apr;195:66-72.e3. doi: 10.1016/j.jpeds.2017.11.036. Epub 2018 Feb 1. J Pediatr. 2018. PMID: 29395186 Free PMC article.
RESULTS: Among 7021 infants, 4184 (60%) underwent cranial imaging. These infants had lower gestational ages and birth weights and higher rates of small for gestational age, outborn birth, cesarean delivery, neonatal resuscitation, and treatment with surfactant, comp …
RESULTS: Among 7021 infants, 4184 (60%) underwent cranial imaging. These infants had lower gestational ages and birth weights and hig …
Delivery Room Resuscitation and Short-Term Outcomes in Moderately Preterm Infants.
Bajaj M, Natarajan G, Shankaran S, Wyckoff M, Laptook AR, Bell EF, Stoll BJ, Carlo WA, Vohr BR, Saha S, Van Meurs KP, Sanchez PJ, D'Angio CT, Higgins RD, Das A, Newman N, Walsh MC; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Bajaj M, et al. J Pediatr. 2018 Apr;195:33-38.e2. doi: 10.1016/j.jpeds.2017.11.039. Epub 2018 Jan 3. J Pediatr. 2018. PMID: 29306493 Free PMC article.
In-Hospital Outcomes Following Extracorporeal Membrane Oxygenation in a Retrospective Cohort of Infants.
Schueller M, Greenberg RG, Smith PB, Laughon MM, Clark RH, Hornik CP. Schueller M, et al. Among authors: laughon mm. Am J Perinatol. 2017 Nov;34(13):1347-1353. doi: 10.1055/s-0037-1603593. Epub 2017 May 25. Am J Perinatol. 2017. PMID: 28561190 Free PMC article.
STUDY DESIGN: We examined a cohort study of infants 32 weeks of gestational age and 1,800 g birth weight supported with ECMO in a Pediatrix Medical Group neonatal intensive care unit from 1998 to 2013. ...Survival to discharge was 87% but was lower in premature compared wi …
STUDY DESIGN: We examined a cohort study of infants 32 weeks of gestational age and 1,800 g birth weight supported with ECMO in a Ped …
Safety of Enalapril in Infants Admitted to the Neonatal Intensive Care Unit.
Ku LC, Zimmerman K, Benjamin DK, Clark RH, Hornik CP, Smith PB; Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee. Ku LC, et al. Pediatr Cardiol. 2017 Jan;38(1):155-161. doi: 10.1007/s00246-016-1496-2. Epub 2016 Nov 8. Pediatr Cardiol. 2017. PMID: 27826711 Free PMC article.
This study is the largest to date examining the safety of enalapril in young term and preterm infants without significant structural cardiac disease....
This study is the largest to date examining the safety of enalapril in young term and preterm infants without significant structural …
Risk Factors and In-Hospital Outcomes following Tracheostomy in Infants.
Lee JH, Smith PB, Quek MB, Laughon MM, Clark RH, Hornik CP. Lee JH, et al. Among authors: laughon mm. J Pediatr. 2016 Jun;173:39-44.e1. doi: 10.1016/j.jpeds.2016.01.072. Epub 2016 Mar 2. J Pediatr. 2016. PMID: 26944265 Free PMC article.
In-hospital mortality after tracheostomy was 14% (125 of 885). On adjusted analysis, near-term gestational age (GA), small for GA status, pulmonary diagnoses, number of days of forced fraction of inspired oxygen >0.4, and inotropic support before tracheostomy were assoc …
In-hospital mortality after tracheostomy was 14% (125 of 885). On adjusted analysis, near-term gestational age (GA), small for GA sta …
16 results