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Acquisition of mitochondrial dysregulation and resistance to mitochondrial-mediated apoptosis after genotoxic insult in normal human fibroblasts: a possible model for early stage carcinogenesis.
Nickens KP, Han Y, Shandilya H, Larrimore A, Gerard GF, Kaldjian E, Patierno SR, Ceryak S. Nickens KP, et al. Among authors: larrimore a. Biochim Biophys Acta. 2012 Feb;1823(2):264-72. doi: 10.1016/j.bbamcr.2011.10.005. Epub 2011 Oct 25. Biochim Biophys Acta. 2012. PMID: 22057391 Free PMC article.
We previously generated sub-populations of BJ-hTERT human diploid fibroblasts, which have acquired death-resistance following exposure to hexavalent chromium [Cr(VI)], a broad-spectrum genotoxicant. Long-term exposure to certain forms of Cr(VI) is associated with respirato …
We previously generated sub-populations of BJ-hTERT human diploid fibroblasts, which have acquired death-resistance following exposure to he …