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Effects of a Partially Supervised Conditioning Program in Cystic Fibrosis: An International Multicenter, Randomized Controlled Trial (ACTIVATE-CF).
Hebestreit H, Kriemler S, Schindler C, Stein L, Karila C, Urquhart DS, Orenstein DM, Lands LC, Schaeff J, Eber E, Radtke T; ACTIVATE-CF Study Working Group. Hebestreit H, et al. Among authors: lands lc. Am J Respir Crit Care Med. 2022 Feb 1;205(3):330-339. doi: 10.1164/rccm.202106-1419OC. Am J Respir Crit Care Med. 2022. PMID: 34735776 Free PMC article. Clinical Trial.
Rationale: The long-term effects of vigorous physical activity (PA) on lung function in cystic fibrosis are unclear. ...
Rationale: The long-term effects of vigorous physical activity (PA) on lung function in cystic fibrosis are unclear. ...
Long-term bone mineral density changes and fractures in lung transplant recipients with cystic fibrosis.
Durette G, Jomphe V, Bureau NJ, Poirier C, Ferraro P, Lands LC, Mailhot G. Durette G, et al. Among authors: lands lc. J Cyst Fibros. 2021 May;20(3):525-532. doi: 10.1016/j.jcf.2020.09.012. Epub 2020 Oct 21. J Cyst Fibros. 2021. PMID: 34108100 Free article.
BACKGROUND: Little is known about long-term bone mineral density (BMD) changes and fractures in lung transplant recipients with cystic fibrosis (CF). ...
BACKGROUND: Little is known about long-term bone mineral density (BMD) changes and fractures in lung transplant recipients with cysti …
Long-term safety and efficacy of tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study.
Flume PA, Biner RF, Downey DG, Brown C, Jain M, Fischer R, De Boeck K, Sawicki GS, Chang P, Paz-Diaz H, Rubin JL, Yang Y, Hu X, Pasta DJ, Millar SJ, Campbell D, Wang X, Ahluwalia N, Owen CA, Wainwright CE; VX14-661-110 study group. Flume PA, et al. Lancet Respir Med. 2021 Jul;9(7):733-746. doi: 10.1016/S2213-2600(20)30510-5. Epub 2021 Feb 10. Lancet Respir Med. 2021. PMID: 33581080
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability, and efficacy of tezacaftor-ivacaftor in participants aged 12 years or older with cystic fibrosis who were homozygous or heterozygous for t …
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability …
Trends, Determinants, and Impact on Survival of Post-Lung Transplant Weight Changes: A Single-center Longitudinal Retrospective Study.
Jomphe V, Nguyen C, Durette G, Chagnon M, Nasir B, Poirier C, Ferraro P, Lands LC, Mailhot G. Jomphe V, et al. Among authors: lands lc. Transplantation. 2019 Dec;103(12):2614-2623. doi: 10.1097/TP.0000000000002696. Transplantation. 2019. PMID: 31765365
Although previous studies have focused on weight changes at fixed time periods and relatively early after transplant, trends over time and long-term weight evolution have not been described in this population. ...
Although previous studies have focused on weight changes at fixed time periods and relatively early after transplant, trends over time and l …
Oral non-steroidal anti-inflammatory drug therapy for lung disease in cystic fibrosis.
Lands LC, Stanojevic S. Lands LC, et al. Cochrane Database Syst Rev. 2019 Sep 9;9(9):CD001505. doi: 10.1002/14651858.CD001505.pub5. Cochrane Database Syst Rev. 2019. PMID: 31499593 Free PMC article.
Data from four trials demonstrated the proportion of participants with at least one hospitalization may be slightly lower in the ibuprofen group compared to placebo, Peto odds ratio 0.61 (95% CI 0.37 to 1.01) (moderate-quality evidence). In one trial, long-term use of high …
Data from four trials demonstrated the proportion of participants with at least one hospitalization may be slightly lower in the ibuprofen g …
Nutritional Requirements of Lung Transplant Recipients: Challenges and Considerations.
Jomphe V, Lands LC, Mailhot G. Jomphe V, et al. Among authors: lands lc. Nutrients. 2018 Jun 19;10(6):790. doi: 10.3390/nu10060790. Nutrients. 2018. PMID: 29921799 Free PMC article. Review.
We provide an overview of the current state of knowledge regarding nutritional requirements in the post-lung transplant period from the immediate post-operative phase to long-term follow-up. In the immediate post-transplantation phase, the high doses of immunosuppressants …
We provide an overview of the current state of knowledge regarding nutritional requirements in the post-lung transplant period from the imme …
The benefits of newborn screening for cystic fibrosis: The Canadian experience.
Mak DY, Sykes J, Stephenson AL, Lands LC. Mak DY, et al. Among authors: lands lc. J Cyst Fibros. 2016 May;15(3):302-8. doi: 10.1016/j.jcf.2016.04.001. Epub 2016 Apr 21. J Cyst Fibros. 2016. PMID: 27118577 Free article.
BACKGROUND: The impact of newborn screening (NBS) for cystic fibrosis (CF) on early indicators of long-term health was evaluated in the context of government-sponsored healthcare and access to current therapies. ...After adjusting for age at clinic visit, gender, pancreati …
BACKGROUND: The impact of newborn screening (NBS) for cystic fibrosis (CF) on early indicators of long-term health was evaluated in t …
Oral non-steroidal anti-inflammatory drug therapy for lung disease in cystic fibrosis.
Lands LC, Stanojevic S. Lands LC, et al. Cochrane Database Syst Rev. 2016 Apr 7;4:CD001505. doi: 10.1002/14651858.CD001505.pub4. Cochrane Database Syst Rev. 2016. PMID: 27055154 Updated. Review.
The post-hoc analysis of data from two trials split by age showed a statistically significant slower rate of annual decline of percent predicted forced expiratory volume in one second and forced vital capacity in the ibuprofen group in younger children, mean difference 1.41% (95% …
The post-hoc analysis of data from two trials split by age showed a statistically significant slower rate of annual decline of percent predi …
Longitudinal relationship between physical activity and lung health in patients with cystic fibrosis.
Schneiderman JE, Wilkes DL, Atenafu EG, Nguyen T, Wells GD, Alarie N, Tullis E, Lands LC, Coates AL, Corey M, Ratjen F. Schneiderman JE, et al. Among authors: lands lc. Eur Respir J. 2014 Mar;43(3):817-23. doi: 10.1183/09031936.00055513. Epub 2013 Oct 31. Eur Respir J. 2014. PMID: 24176992 Free article.
Exercise is beneficial for patients with cystic fibrosis (CF) but long-term effects of physical activity on lung function evolution are unknown. ...
Exercise is beneficial for patients with cystic fibrosis (CF) but long-term effects of physical activity on lung function evolution a …
Oral non-steroidal anti-inflammatory drug therapy for lung disease in cystic fibrosis.
Lands LC, Stanojevic S. Lands LC, et al. Cochrane Database Syst Rev. 2013 Jun 13;(6):CD001505. doi: 10.1002/14651858.CD001505.pub3. Cochrane Database Syst Rev. 2013. PMID: 23765216 Updated. Review.
The post-hoc analysis of data from two trials split by age showed a statistically significant slower rate of annual decline of % predicted FEV1 and FVC in the ibuprofen group in younger children, MD 1.41% (95% CI 0.03 to 2.80) and MD 1.32% (95% CI 0.04 to 2.60) respectively. In o …
The post-hoc analysis of data from two trials split by age showed a statistically significant slower rate of annual decline of % predicted F …
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