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Metformin Attenuates Hyperglycaemia-Stimulated Pro-Fibrotic Gene Expression in Adventitial Fibroblasts via Inhibition of Discoidin Domain Receptor 2.
Titus AS, Ushakumary MG, Venugopal H, Wang M, Lakatta EG, Kailasam S. Titus AS, et al. Among authors: lakatta eg. Int J Mol Sci. 2022 Dec 29;24(1):585. doi: 10.3390/ijms24010585. Int J Mol Sci. 2022. PMID: 36614028 Free PMC article.
Molecular mechanisms underlying the diverse therapeutic effects of anti-diabetic metformin, beyond its anti-hyperglycaemic effects, remain largely unclear. Metformin is reported to reduce the long-term complications of diabetes, including cardiovascular fibrosis and remode …
Molecular mechanisms underlying the diverse therapeutic effects of anti-diabetic metformin, beyond its anti-hyperglycaemic effects, remain l …
Disulfiram Treatment Normalizes Body Weight in Obese Mice.
Bernier M, Mitchell SJ, Wahl D, Diaz A, Singh A, Seo W, Wang M, Ali A, Kaiser T, Price NL, Aon MA, Kim EY, Petr MA, Cai H, Warren A, Di Germanio C, Di Francesco A, Fishbein K, Guiterrez V, Harney D, Koay YC, Mach J, Enamorado IN, Pulpitel T, Wang Y, Zhang J, Zhang L, Spencer RG, Becker KG, Egan JM, Lakatta EG, O'Sullivan J, Larance M, LeCouteur DG, Cogger VC, Gao B, Fernandez-Hernando C, Cuervo AM, de Cabo R. Bernier M, et al. Among authors: lakatta eg. Cell Metab. 2020 Aug 4;32(2):203-214.e4. doi: 10.1016/j.cmet.2020.04.019. Epub 2020 May 14. Cell Metab. 2020. PMID: 32413333 Free PMC article.
Reductions in feeding efficiency and increases in energy expenditure were associated with body weight regulation in response to long-term disulfiram treatment. Loss of fat tissue and an increase in liver fenestrations were also observed in rats on disulfiram. ...
Reductions in feeding efficiency and increases in energy expenditure were associated with body weight regulation in response to long-term …
Long-term low dose dietary resveratrol supplement reduces cardiovascular structural and functional deterioration in chronic heart failure in rats.
Ahmet I, Tae HJ, Lakatta EG, Talan M. Ahmet I, et al. Among authors: lakatta eg. Can J Physiol Pharmacol. 2017 Mar;95(3):268-274. doi: 10.1139/cjpp-2016-0512. Epub 2016 Dec 17. Can J Physiol Pharmacol. 2017. PMID: 28134561 Free PMC article.
A short-term exposure to resveratrol at high dosages exerts a remarkable cardioprotective effect. Whether a long-term exposure to resveratrol at low dosages that can be obtained through consumption of a resveratrol-rich diet is beneficial to heart diseases is unknow …
A short-term exposure to resveratrol at high dosages exerts a remarkable cardioprotective effect. Whether a long-term exposure …
Hemodynamic Determinants of the Short-Term Blood Pressure Variability: Differential Roles of Arterial Stiffness and Wave Reflection.
Hsu PF, Cheng HM, Sung SH, Chuang SY, Lakatta EG, Yin FC, Chou P, Chen CH. Hsu PF, et al. Among authors: lakatta eg. Am J Hypertens. 2017 Mar 1;30(3):256-263. doi: 10.1093/ajh/hpw144. Am J Hypertens. 2017. PMID: 28096150 Free PMC article.
BACKGROUND: A high 24-hour ambulatory diastolic (DBP) but not systolic (SBP) blood pressure variability (BPV) is significantly predictive of long-term cardiovascular mortality in untreated hypertensive subjects, independent of office or 24-hour SBP. ...
BACKGROUND: A high 24-hour ambulatory diastolic (DBP) but not systolic (SBP) blood pressure variability (BPV) is significantly predictive of …
Prognostic significance of mechanical biomarkers derived from pulse wave analysis for predicting long-term cardiovascular mortality in two population-based cohorts.
Cheng HM, Chuang SY, Wang JJ, Shih YT, Wang HN, Huang CJ, Huang JT, Sung SH, Lakatta EG, Yin FC, Chou P, Yeh CJ, Bai CH, Pan WH, Chen CH. Cheng HM, et al. Among authors: lakatta eg. Int J Cardiol. 2016 Jul 15;215:388-95. doi: 10.1016/j.ijcard.2016.04.070. Epub 2016 Apr 17. Int J Cardiol. 2016. PMID: 27128568 Free PMC article.
High Short-Term Blood Pressure Variability Predicts Long-Term Cardiovascular Mortality in Untreated Hypertensives But Not in Normotensives.
Hsu PF, Cheng HM, Wu CH, Sung SH, Chuang SY, Lakatta EG, Yin FC, Chou P, Chen CH. Hsu PF, et al. Among authors: lakatta eg. Am J Hypertens. 2016 Jul;29(7):806-13. doi: 10.1093/ajh/hpw002. Epub 2016 Feb 1. Am J Hypertens. 2016. PMID: 26837643 Free PMC article.
BACKGROUND: The prognostic value of the short-term blood pressure variability (BPV) from the 24-hour ambulatory blood pressure monitoring (ABPM) remains controversial. ...A high ARVd or ARVs did not significantly predict cardiovascular mortality in the normotensive subject …
BACKGROUND: The prognostic value of the short-term blood pressure variability (BPV) from the 24-hour ambulatory blood pressure monito …
The conundrum of arterial stiffness, elevated blood pressure, and aging.
AlGhatrif M, Lakatta EG. AlGhatrif M, et al. Among authors: lakatta eg. Curr Hypertens Rep. 2015 Feb;17(2):12. doi: 10.1007/s11906-014-0523-z. Curr Hypertens Rep. 2015. PMID: 25687599 Free PMC article. Review.
This homeostasis is disturbed by age-associated, minute alterations in aortic hemodynamic and mechanical properties that induce short- and long-term alterations in each other. Hence, it is impossible to detect an "initial insult" at an epidemiological level. ...
This homeostasis is disturbed by age-associated, minute alterations in aortic hemodynamic and mechanical properties that induce short- and l …
Plasma level of the endogenous sodium pump ligand marinobufagenin is related to the salt-sensitivity in men.
Fedorova OV, Lakatta EG, Bagrov AY, Melander O. Fedorova OV, et al. Among authors: lakatta eg. J Hypertens. 2015 Mar;33(3):534-41; discussion 541. doi: 10.1097/HJH.0000000000000437. J Hypertens. 2015. PMID: 25479026 Free PMC article.
Here, we tested, in humans, whether MBG levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake induces changes in MBG and any salt-induced change in MBG is related to salt sensitivity. ...
Here, we tested, in humans, whether MBG levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake …
Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations.
Ganesh SK, Chasman DI, Larson MG, Guo X, Verwoert G, Bis JC, Gu X, Smith AV, Yang ML, Zhang Y, Ehret G, Rose LM, Hwang SJ, Papanicolau GJ, Sijbrands EJ, Rice K, Eiriksdottir G, Pihur V, Ridker PM, Vasan RS, Newton-Cheh C; Global Blood Pressure Genetics Consortium; Raffel LJ, Amin N, Rotter JI, Liu K, Launer LJ, Xu M, Caulfield M, Morrison AC, Johnson AD, Vaidya D, Dehghan A, Li G, Bouchard C, Harris TB, Zhang H, Boerwinkle E, Siscovick DS, Gao W, Uitterlinden AG, Rivadeneira F, Hofman A, Willer CJ, Franco OH, Huo Y, Witteman JC, Munroe PB, Gudnason V, Palmas W, van Duijn C, Fornage M, Levy D, Psaty BM, Chakravarti A. Ganesh SK, et al. Am J Hum Genet. 2014 Jul 3;95(1):49-65. doi: 10.1016/j.ajhg.2014.06.002. Epub 2014 Jun 26. Am J Hum Genet. 2014. PMID: 24975945 Free PMC article.

Replication analyses conducted in cohorts with single-visit BP data showed positive replication of associations and a nominal association (p < 0.05). We estimated a 20% gain in statistical power with long-term average (LTA) as compared to single-visit BP association stu

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Replication analyses conducted in cohorts with single-visit BP data showed positive replication of associations and a nominal association (p …
Derivation and validation of diagnostic thresholds for central blood pressure measurements based on long-term cardiovascular risks.
Cheng HM, Chuang SY, Sung SH, Yu WC, Pearson A, Lakatta EG, Pan WH, Chen CH. Cheng HM, et al. Among authors: lakatta eg. J Am Coll Cardiol. 2013 Nov 5;62(19):1780-7. doi: 10.1016/j.jacc.2013.06.029. Epub 2013 Jul 10. J Am Coll Cardiol. 2013. PMID: 23850921 Free PMC article.
CONCLUSIONS: CBP of 130/90 mm Hg was determined to be the cutoff limit for normality and was characterized by a greater discriminatory power for long-term events in our validation cohort. This report represents an important step toward the application of the CBP concept in …
CONCLUSIONS: CBP of 130/90 mm Hg was determined to be the cutoff limit for normality and was characterized by a greater discriminatory power …
28 results