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PROTECTIVE EFFECTS OF HUMANIN-G IN HEMORRHAGIC SHOCK IN FEMALE MICE VIA AMPKα1-INDEPENDENT MECHANISMS.
Wagner ML, Ammann A, Piraino G, Wolfe V, O'Connor M, Lahni P, Ziady A, Zingarelli B. Wagner ML, et al. Among authors: lahni p. Shock. 2023 Jul 1;60(1):64-74. doi: 10.1097/SHK.0000000000002134. Epub 2023 Apr 21. Shock. 2023. PMID: 37079467
Methods: AMPKalpha1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood and lactated Ringer's solution. In short-term studies, mice were treated with humanin-G or vehicle and sacrificed at 3 h after resuscit …
Methods: AMPKalpha1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood an …
Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.
Urban C, Hayes HV, Piraino G, Wolfe V, Lahni P, O'Connor M, Phares C, Zingarelli B. Urban C, et al. Among authors: lahni p. Front Immunol. 2022 Sep 2;13:984298. doi: 10.3389/fimmu.2022.984298. eCollection 2022. Front Immunol. 2022. PMID: 36119052 Free PMC article.
At molecular analysis, colivelin treatment was associated with inhibition of the signal transducer and activator of transcription 3 and activation of the AMP-activated protein kinase in the aorta and lung. In long-term outcomes studies up to 7 days, co-treatment of colivel …
At molecular analysis, colivelin treatment was associated with inhibition of the signal transducer and activator of transcription 3 and acti …
Combined zinc supplementation with proinsulin C-peptide treatment decreases the inflammatory response and mortality in murine polymicrobial sepsis.
Slinko S, Piraino G, Hake PW, Ledford JR, O'Connor M, Lahni P, Solan PD, Wong HR, Zingarelli B. Slinko S, et al. Among authors: lahni p. Shock. 2014 Apr;41(4):292-300. doi: 10.1097/SHK.0000000000000127. Shock. 2014. PMID: 24430544 Free PMC article.
These beneficial effects were associated with restored lung nuclear expression of PPARgamma and reduction of phosphorylated extracellular signal-regulated kinases 1 and 2 and nuclear factor kappaB activities in comparison to vehicle or single treatment protocols. Our data demonst …
These beneficial effects were associated with restored lung nuclear expression of PPARgamma and reduction of phosphorylated extracellular si …
Short-term high fat feeding increases organ injury and mortality after polymicrobial sepsis.
Kaplan JM, Nowell M, Lahni P, O'Connor MP, Hake PW, Zingarelli B. Kaplan JM, et al. Among authors: lahni p. Obesity (Silver Spring). 2012 Oct;20(10):1995-2002. doi: 10.1038/oby.2012.40. Epub 2012 Feb 15. Obesity (Silver Spring). 2012. PMID: 22334256 Free PMC article.
The purpose of this study was to examine the effect of short-term high fat feeding on the inflammatory response in polymicrobial sepsis. ...
The purpose of this study was to examine the effect of short-term high fat feeding on the inflammatory response in polymicrobial seps …