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Kidney-in-a-lymph node: A novel organogenesis assay to model human renal development and test nephron progenitor cell fates.
Francipane MG, Han B, Oxburgh L, Sims-Lucas S, Li Z, Lagasse E. Francipane MG, et al. Among authors: lagasse e. J Tissue Eng Regen Med. 2019 Sep;13(9):1724-1731. doi: 10.1002/term.2924. Epub 2019 Jul 30. J Tissue Eng Regen Med. 2019. PMID: 31267702 Free PMC article.
Unfortunately, although organoids containing renal structures have been generated from mouse and human pluripotent stem cells, there are still critical unanswered questions that are difficult to attain via in vitro systems, including whether these nonvascularized organoids have a …
Unfortunately, although organoids containing renal structures have been generated from mouse and human pluripotent stem cells, there are sti …
Establishment and Characterization of 5-Fluorouracil-Resistant Human Colorectal Cancer Stem-Like Cells: Tumor Dynamics under Selection Pressure.
Francipane MG, Bulanin D, Lagasse E. Francipane MG, et al. Among authors: lagasse e. Int J Mol Sci. 2019 Apr 12;20(8):1817. doi: 10.3390/ijms20081817. Int J Mol Sci. 2019. PMID: 31013771 Free PMC article.
To identify mechanisms of drug resistance, CRC stem-like cells were subjected to long-term 5-FU selection using either intermittent treatment regimen with the IC50 drug dose or continuous treatment regimen with escalating drug doses. ...
To identify mechanisms of drug resistance, CRC stem-like cells were subjected to long-term 5-FU selection using either intermittent t …
Identification, expansion and characterization of cancer cells with stem cell properties from head and neck squamous cell carcinomas.
Kaseb HO, Fohrer-Ting H, Lewis DW, Lagasse E, Gollin SM. Kaseb HO, et al. Among authors: lagasse e. Exp Cell Res. 2016 Oct 15;348(1):75-86. doi: 10.1016/j.yexcr.2016.09.003. Epub 2016 Sep 9. Exp Cell Res. 2016. PMID: 27619333 Free PMC article.
We show that spheroid enrichment of CSC from early and short-term HNSCC cell cultures was associated with increased expression of CD44, CD133, SOX2 and BMI1 compared with normal oral epithelial cells. ...
We show that spheroid enrichment of CSC from early and short-term HNSCC cell cultures was associated with increased expression of CD4 …
Identification of a candidate stem cell in human gallbladder.
Manohar R, Li Y, Fohrer H, Guzik L, Stolz DB, Chandran UR, LaFramboise WA, Lagasse E. Manohar R, et al. Among authors: lagasse e. Stem Cell Res. 2015 May;14(3):258-69. doi: 10.1016/j.scr.2014.12.003. Epub 2015 Feb 7. Stem Cell Res. 2015. PMID: 25765520 Free PMC article.
Primary EpCAM+CD44+CD13+ cells gave rise to EpCAM+CD44+CD13+ and EpCAM+CD44+CD13- cells in vitro, and gallbladder cells expanded in vitro exhibited short-term engraftment in vivo. Last, we found that CD13, CD227, CD66, CD26 and CD49b were differentially expressed between g …
Primary EpCAM+CD44+CD13+ cells gave rise to EpCAM+CD44+CD13+ and EpCAM+CD44+CD13- cells in vitro, and gallbladder cells expanded in vitro ex …
The lymph node as a new site for kidney organogenesis.
Francipane MG, Lagasse E. Francipane MG, et al. Among authors: lagasse e. Stem Cells Transl Med. 2015 Mar;4(3):295-307. doi: 10.5966/sctm.2014-0208. Epub 2015 Feb 2. Stem Cells Transl Med. 2015. PMID: 25646529 Free PMC article.
Thus, the LN might provide a unique tool for studying the mechanisms of renal maturation, cell proliferation, and fluid secretion during cyst development. Moreover, we provide evidence that inside the LN, short-term cultured embryonic kidney cells stimulated with the Wnt a …
Thus, the LN might provide a unique tool for studying the mechanisms of renal maturation, cell proliferation, and fluid secretion during cys …
Cancer Stem Cells: A Moving Target.
Francipane MG, Chandler J, Lagasse E. Francipane MG, et al. Among authors: lagasse e. Curr Pathobiol Rep. 2013 Jun 1;1(2):111-118. doi: 10.1007/s40139-013-0010-2. Curr Pathobiol Rep. 2013. PMID: 23914341 Free PMC article.
The main explanation for such a dismal prognosis is that current therapies might leave behind a population of cancer cells with the capacity for long-term self-renewal, so-called cancer stem cells (CSCs), from which most tumors are believed to be derived and fueled. ...
The main explanation for such a dismal prognosis is that current therapies might leave behind a population of cancer cells with the capacity …
Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming.
Hickey RD, Galivo F, Schug J, Brehm MA, Haft A, Wang Y, Benedetti E, Gu G, Magnuson MA, Shultz LD, Lagasse E, Greiner DL, Kaestner KH, Grompe M. Hickey RD, et al. Among authors: lagasse e. Stem Cell Res. 2013 Jul;11(1):503-15. doi: 10.1016/j.scr.2013.02.005. Epub 2013 Feb 18. Stem Cell Res. 2013. PMID: 23562832 Free PMC article.
Reprogramming was also enhanced by addition of retinoic acid and inhibition of Notch signaling. Importantly, rGBCs were able to engraft long term in vivo and remained insulin-positive for 15weeks. We conclude that GBCs are a viable source for autologous cell replacement in …
Reprogramming was also enhanced by addition of retinoic acid and inhibition of Notch signaling. Importantly, rGBCs were able to engraft long …
Identification and expansion of a unique stem cell population from adult mouse gallbladder.
Manohar R, Komori J, Guzik L, Stolz DB, Chandran UR, LaFramboise WA, Lagasse E. Manohar R, et al. Among authors: lagasse e. Hepatology. 2011 Nov;54(5):1830-41. doi: 10.1002/hep.24568. Hepatology. 2011. PMID: 21793026 Free PMC article.
EpCAM(+) CD49f(hi) cells expressed cluster of differentiation (CD)29, CD133, and stem cell antigen-1, but were negative for lineage markers CD31, CD45, and F4/80. Using a novel feeder cell-culture system, we observed long-term (>passage 20) and clonal expansion of the E …
EpCAM(+) CD49f(hi) cells expressed cluster of differentiation (CD)29, CD133, and stem cell antigen-1, but were negative for lineage markers …