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Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease.
Javonillo DI, Tran KM, Phan J, Hingco E, Kramár EA, da Cunha C, Forner S, Kawauchi S, Milinkeviciute G, Gomez-Arboledas A, Neumann J, Banh CE, Huynh M, Matheos DP, Rezaie N, Alcantara JA, Mortazavi A, Wood MA, Tenner AJ, MacGregor GR, Green KN, LaFerla FM. Javonillo DI, et al. Among authors: laferla fm. Front Neurosci. 2022 Jan 24;15:785276. doi: 10.3389/fnins.2021.785276. eCollection 2021. Front Neurosci. 2022. PMID: 35140584 Free PMC article.
This modern characterization of the 3xTg-AD model includes an assessment of impairments in long-term potentiation followed by quantification of amyloid beta (Abeta) plaque burden and neurofibrillary tau tangles, biochemical levels of Abeta and tau protein, and neuropatholo …
This modern characterization of the 3xTg-AD model includes an assessment of impairments in long-term potentiation followed by quantif …
Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer's disease.
Forner S, Kawauchi S, Balderrama-Gutierrez G, Kramár EA, Matheos DP, Phan J, Javonillo DI, Tran KM, Hingco E, da Cunha C, Rezaie N, Alcantara JA, Baglietto-Vargas D, Jansen C, Neumann J, Wood MA, MacGregor GR, Mortazavi A, Tenner AJ, LaFerla FM, Green KN. Forner S, et al. Among authors: laferla fm. Sci Data. 2021 Oct 15;8(1):270. doi: 10.1038/s41597-021-01054-y. Sci Data. 2021. PMID: 34654824 Free PMC article.
miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease.
Rodriguez-Ortiz CJ, Prieto GA, Martini AC, Forner S, Trujillo-Estrada L, LaFerla FM, Baglietto-Vargas D, Cotman CW, Kitazawa M. Rodriguez-Ortiz CJ, et al. Among authors: laferla fm. Aging Cell. 2020 Mar;19(3):e13118. doi: 10.1111/acel.13118. Epub 2020 Feb 22. Aging Cell. 2020. PMID: 32087004 Free PMC article.
In primary hippocampal cultures, we found that an activity-dependent upregulation of the microRNA-regulating protein, translin, correlated with reduction of miR-181a upon chemical long-term potentiation (cLTP), which induced upregulation of GluA2, a predicted target for mi …
In primary hippocampal cultures, we found that an activity-dependent upregulation of the microRNA-regulating protein, translin, correlated w …
Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus.
Forner S, Martini AC, Prieto GA, Dang CT, Rodriguez-Ortiz CJ, Reyes-Ruiz JM, Trujillo-Estrada L, da Cunha C, Andrews EJ, Phan J, Vu Ha J, Chang AVZD, Levites Y, Cruz PE, Ager R, Medeiros R, Kitazawa M, Glabe CG, Cotman CW, Golde T, Baglietto-Vargas D, LaFerla FM. Forner S, et al. Among authors: laferla fm. Sci Rep. 2019 Nov 4;9(1):15936. doi: 10.1038/s41598-019-52324-0. Sci Rep. 2019. PMID: 31685865 Free PMC article.
We observed that expression of Abeta in both cellular compartments affect learning and memory, reduce the number of synapses and the expression of synaptic-related proteins, and disrupt chemical long-term potentiation (cLTP). Together, these findings indicate that during t …
We observed that expression of Abeta in both cellular compartments affect learning and memory, reduce the number of synapses and the express …
Sex-dependent co-occurrence of hypoxia and beta-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3 Tg-AD mouse model of Alzheimer's disease.
Frontiñán-Rubio J, Sancho-Bielsa FJ, Peinado JR, LaFerla FM, Giménez-Llort L, Durán-Prado M, Alcain FJ. Frontiñán-Rubio J, et al. Among authors: laferla fm. Mol Cell Neurosci. 2018 Oct;92:67-81. doi: 10.1016/j.mcn.2018.06.005. Epub 2018 Jun 25. Mol Cell Neurosci. 2018. PMID: 29953929 Free article.
This study investigated whether these and other alterations in the cerebrovascular system associated with AD can be prevented by long-term dietary supplementation with the antioxidant ubiquinol (Ub) stabilized with Kaneka QH P30 powder containing ascorbic acid (ASC) in a m …
This study investigated whether these and other alterations in the cerebrovascular system associated with AD can be prevented by long-ter …
Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease.
Sosna J, Philipp S, Albay R 3rd, Reyes-Ruiz JM, Baglietto-Vargas D, LaFerla FM, Glabe CG. Sosna J, et al. Among authors: laferla fm. Mol Neurodegener. 2018 Mar 1;13(1):11. doi: 10.1186/s13024-018-0244-x. Mol Neurodegener. 2018. PMID: 29490706 Free PMC article.
Directly after this treatment, we analyzed the amount of intraneuronal amyloid and neuritic plaques and performed behavioral studies including Y-maze, fear conditioning and elevated plus maze. RESULTS: We found that early long-term PLX3397 administration results in a drama …
Directly after this treatment, we analyzed the amount of intraneuronal amyloid and neuritic plaques and performed behavioral studies includi …
Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus.
Prieto GA, Snigdha S, Baglietto-Vargas D, Smith ED, Berchtold NC, Tong L, Ajami D, LaFerla FM, Rebek J Jr, Cotman CW. Prieto GA, et al. Among authors: laferla fm. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E5078-87. doi: 10.1073/pnas.1514486112. Epub 2015 Aug 24. Proc Natl Acad Sci U S A. 2015. PMID: 26305968 Free PMC article.
To evaluate whether synapses develop a similar heightened sensitivity to IL-1beta with age, we used an assay to track long-term potentiation (LTP) in synaptosomes. We found that IL-1beta impairs LTP directly at the synapse and that sensitivity to IL-1beta is augmented in a …
To evaluate whether synapses develop a similar heightened sensitivity to IL-1beta with age, we used an assay to track long-term poten …
Short-term modern life-like stress exacerbates Abeta-pathology and synapse loss in 3xTg-AD mice.
Baglietto-Vargas D, Chen Y, Suh D, Ager RR, Rodriguez-Ortiz CJ, Medeiros R, Myczek K, Green KN, Baram TZ, LaFerla FM. Baglietto-Vargas D, et al. Among authors: laferla fm. J Neurochem. 2015 Sep;134(5):915-26. doi: 10.1111/jnc.13195. Epub 2015 Jul 14. J Neurochem. 2015. PMID: 26077803 Free PMC article.
Current epidemiological evidence indicates that life experiences, including chronic stress, are a risk for AD. However, it is unknown if short-term stress, lasting for hours, influences the onset or progression of AD. Here, we determined the effect of short-term, mu …
Current epidemiological evidence indicates that life experiences, including chronic stress, are a risk for AD. However, it is unknown if sho …
Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models.
Blurton-Jones M, Spencer B, Michael S, Castello NA, Agazaryan AA, Davis JL, Müller FJ, Loring JF, Masliah E, LaFerla FM. Blurton-Jones M, et al. Among authors: laferla fm. Stem Cell Res Ther. 2014 Apr 16;5(2):46. doi: 10.1186/scrt440. Stem Cell Res Ther. 2014. PMID: 25022790 Free PMC article.
INTRODUCTION: Short-term neural stem cell (NSC) transplantation improves cognition in Alzheimer's disease (AD) transgenic mice by enhancing endogenous synaptic connectivity. However, this approach has no effect on the underlying beta-amyloid (Abeta) and neurofibrillary tan …
INTRODUCTION: Short-term neural stem cell (NSC) transplantation improves cognition in Alzheimer's disease (AD) transgenic mice by enh …
α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles.
Medeiros R, Castello NA, Cheng D, Kitazawa M, Baglietto-Vargas D, Green KN, Esbenshade TA, Bitner RS, Decker MW, LaFerla FM. Medeiros R, et al. Among authors: laferla fm. Am J Pathol. 2014 Feb;184(2):520-9. doi: 10.1016/j.ajpath.2013.10.010. Epub 2013 Nov 19. Am J Pathol. 2014. PMID: 24269557 Free article.
Recent evidence suggests that activating alpha7 nicotinic acetylcholine receptors (alpha7 nAChR) may facilitate the specific modulation of brain cholinergic signaling, leading to cognitive enhancement and possibly to amelioration of AD pathologic findings. In the present study, w …
Recent evidence suggests that activating alpha7 nicotinic acetylcholine receptors (alpha7 nAChR) may facilitate the specific modulation of b …
20 results