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Exuberant fibroblast activity compromises lung function via ADAMTS4.
Boyd DF, Allen EK, Randolph AG, Guo XJ, Weng Y, Sanders CJ, Bajracharya R, Lee NK, Guy CS, Vogel P, Guan W, Li Y, Liu X, Novak T, Newhams MM, Fabrizio TP, Wohlgemuth N, Mourani PM; PALISI Pediatric Intensive Care Influenza (PICFLU) Investigators; Wight TN, Schultz-Cherry S, Cormier SA, Shaw-Saliba K, Pekosz A, Rothman RE, Chen KF, Yang Z, Webby RJ, Zhong N, Crawford JC, Thomas PG. Boyd DF, et al. Nature. 2020 Nov;587(7834):466-471. doi: 10.1038/s41586-020-2877-5. Epub 2020 Oct 28. Nature. 2020. PMID: 33116313 Free PMC article.
Here we demonstrate that respiratory viral infection induces distinct fibroblast activation states, which we term extracellular matrix (ECM)-synthesizing, damage-responsive and interferon-responsive states. ...
Here we demonstrate that respiratory viral infection induces distinct fibroblast activation states, which we term extracellular matri …
Tracheostomy for infants requiring prolonged mechanical ventilation: 10 years' experience.
Overman AE, Liu M, Kurachek SC, Shreve MR, Maynard RC, Mammel MC, Moore BM. Overman AE, et al. Among authors: kurachek sc. Pediatrics. 2013 May;131(5):e1491-6. doi: 10.1542/peds.2012-1943. Epub 2013 Apr 8. Pediatrics. 2013. PMID: 23569088
Infants were divided into 2 groups based on birth weight 1000 g (A) and >1000 g (B). Group A: 87 (57.6%) infants; group B 64 (42.4%). ...CONCLUSIONS: Tracheostomy rates were higher for extremely low birth weight infants than previously reported rates for all infa …
Infants were divided into 2 groups based on birth weight 1000 g (A) and >1000 g (B). Group A: 87 (57.6%) infants; group B 64 (42.4 …