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Coronary Angiography After Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation: One-Year Outcomes of a Randomized Clinical Trial.
Desch S, Freund A, Akin I, Behnes M, Preusch MR, Zelniker TA, Skurk C, Landmesser U, Graf T, Eitel I, Fuernau G, Haake H, Nordbeck P, Hammer F, Felix SB, Hassager C, Kjærgaard J, Fichtlscherer S, Ledwoch J, Lenk K, Joner M, Steiner S, Liebetrau C, Voigt I, Zeymer U, Brand M, Schmitz R, Horstkotte J, Jacobshagen C, Pöss J, Abdel-Wahab M, Lurz P, Jobs A, de Waha S, Olbrich D, Sandig F, König IR, Brett S, Vens M, Klinge K, Thiele H; TOMAHAWK Investigators. Desch S, et al. JAMA Cardiol. 2023 Sep 1;8(9):827-834. doi: 10.1001/jamacardio.2023.2264. JAMA Cardiol. 2023. PMID: 37556123
IMPORTANCE: Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest (OHCA). The long-term effect of early coronary angiography on patients with OHCA with possible coronary trigger but no ST-segment elevation remains unclear. ...
IMPORTANCE: Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest (OHCA). The long-term effect of early coronar …
Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52.
Stirm M, Shashikadze B, Blutke A, Kemter E, Lange A, Stöckl JB, Jaudas F, Laane L, Kurome M, Keßler B, Zakhartchenko V, Bähr A, Klymiuk N, Nagashima H, Walter MC, Wurst W, Kupatt C, Fröhlich T, Wolf E. Stirm M, et al. Among authors: kupatt c. Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2301250120. doi: 10.1073/pnas.2301250120. Epub 2023 Jul 10. Proc Natl Acad Sci U S A. 2023. PMID: 37428903 Free PMC article.
Our findings indicate that ubiquitous deletion of DMD exon 51 in DMDdelta52 pigs largely rescues the rapidly progressing, severe muscular dystrophy and the reduced cardiac function of this model. Long-term follow-up studies of DMDdelta51-52 pigs will show if they develop s …
Our findings indicate that ubiquitous deletion of DMD exon 51 in DMDdelta52 pigs largely rescues the rapidly progressing, severe muscular dy …
Interdependence of Angiogenesis and Arteriogenesis in Development and Disease.
le Noble F, Kupatt C. le Noble F, et al. Among authors: kupatt c. Int J Mol Sci. 2022 Mar 31;23(7):3879. doi: 10.3390/ijms23073879. Int J Mol Sci. 2022. PMID: 35409246 Free PMC article. Review.
We provide evidence showing that this loss of synchronization reduces arterial collateral network recruitment upon arterial stenosis, and the long-term clinical outcome of current revascularization strategies in these patient cohorts. We describe mechanisms and signals con …
We provide evidence showing that this loss of synchronization reduces arterial collateral network recruitment upon arterial stenosis, and th …
Endothelial Retargeting of AAV9 In Vivo.
Bozoglu T, Lee S, Ziegler T, Jurisch V, Maas S, Baehr A, Hinkel R, Hoenig A, Hariharan A, Kim CI, Decker S, Sami H, Koppara T, Oellinger R, Müller OJ, Frank D, Megens R, Nelson P, Weber C, Schnieke A, Sperandio M, Santamaria G, Rad R, Moretti A, Laugwitz KL, Soehnlein O, Ogris M, Kupatt C. Bozoglu T, et al. Among authors: kupatt c. Adv Sci (Weinh). 2022 Mar;9(7):e2103867. doi: 10.1002/advs.202103867. Epub 2022 Jan 12. Adv Sci (Weinh). 2022. PMID: 35023328 Free PMC article.
Functionally, G2(CNN) AAV9-S1FG mediates S1FG-leukocyte adhesion, whereas G2(CNN) AAV9-Anxa1-application reduces long-term leukocyte recruitment. Moreover, blood pressure increases in Cas9-expressing mice subjected to G2(CNN) AAV9-gRNA(eNOS) . ...
Functionally, G2(CNN) AAV9-S1FG mediates S1FG-leukocyte adhesion, whereas G2(CNN) AAV9-Anxa1-application reduces long-term leukocyte …
Agrin Promotes Coordinated Therapeutic Processes Leading to Improved Cardiac Repair in Pigs.
Baehr A, Umansky KB, Bassat E, Jurisch V, Klett K, Bozoglu T, Hornaschewitz N, Solyanik O, Kain D, Ferraro B, Cohen-Rabi R, Krane M, Cyran C, Soehnlein O, Laugwitz KL, Hinkel R, Kupatt C, Tzahor E. Baehr A, et al. Among authors: kupatt c. Circulation. 2020 Sep;142(9):868-881. doi: 10.1161/CIRCULATIONAHA.119.045116. Epub 2020 Jun 8. Circulation. 2020. PMID: 32508131
A single dose of recombinant human agrin improved heart function, infarct size, fibrosis, and adverse remodeling parameters 28 days after MI. Short-term MI experiments along with complementary murine studies revealed myocardial protection, improved angiogenesis, inflammato …
A single dose of recombinant human agrin improved heart function, infarct size, fibrosis, and adverse remodeling parameters 28 days after MI …
The importance of the Heart Team evaluation before transcatheter aortic valve replacement: Results from the BRAVO-3 trial.
Camaj A, Claessen BE, Mehran R, Yudi MB, Power D, Baber U, Hengstenberg C, Lefevre T, Van Belle E, Giustino G, Guedeney P, Sorrentino S, Kupatt C, Webb JG, Hildick-Smith D, Hink HU, Deliargyris EN, Anthopoulos P, Sharma SK, Kini A, Sartori S, Chandrasekhar J, Dangas GD. Camaj A, et al. Among authors: kupatt c. Catheter Cardiovasc Interv. 2020 Dec;96(7):E688-E694. doi: 10.1002/ccd.28717. Epub 2020 Jan 13. Catheter Cardiovasc Interv. 2020. PMID: 31943717
CONCLUSION: Patients undergoing TAVR and labeled high-risk by LES 18 or Heart Team assessment despite LES < 18 have comparable short-term outcomes. Assignment of high-risk status to over 50% of patients is attributable to Heart Team's clinical assessment....

CONCLUSION: Patients undergoing TAVR and labeled high-risk by LES 18 or Heart Team assessment despite LES < 18 have comparable short-t

…
Five-Year Outcomes after PCI or CABG for Left Main Coronary Disease.
Stone GW, Kappetein AP, Sabik JF, Pocock SJ, Morice MC, Puskas J, Kandzari DE, Karmpaliotis D, Brown WM 3rd, Lembo NJ, Banning A, Merkely B, Horkay F, Boonstra PW, van Boven AJ, Ungi I, Bogáts G, Mansour S, Noiseux N, Sabaté M, Pomar J, Hickey M, Gershlick A, Buszman PE, Bochenek A, Schampaert E, Pagé P, Modolo R, Gregson J, Simonton CA, Mehran R, Kosmidou I, Généreux P, Crowley A, Dressler O, Serruys PW; EXCEL Trial Investigators. Stone GW, et al. N Engl J Med. 2019 Nov 7;381(19):1820-1830. doi: 10.1056/NEJMoa1909406. Epub 2019 Sep 28. N Engl J Med. 2019. PMID: 31562798 Free article. Clinical Trial.
BACKGROUND: Long-term outcomes after percutaneous coronary intervention (PCI) with contemporary drug-eluting stents, as compared with coronary-artery bypass grafting (CABG), in patients with left main coronary artery disease are not clearly established. ...
BACKGROUND: Long-term outcomes after percutaneous coronary intervention (PCI) with contemporary drug-eluting stents, as compared with …
Monocyte-platelet aggregates affect local inflammation in patients with acute myocardial infarction.
Kossmann H, Rischpler C, Hanus F, Nekolla SG, Kunze KP, Götze K, Goedel A, Sager H, Kastrati A, Sinnecker D, Kupatt C, Ibrahim T, Schwaiger M, Laugwitz KL, Dirschinger RJ. Kossmann H, et al. Among authors: kupatt c. Int J Cardiol. 2019 Jul 15;287:7-12. doi: 10.1016/j.ijcard.2019.04.009. Epub 2019 Apr 8. Int J Cardiol. 2019. PMID: 31003796
Myocardial inflammation can be visualized in patients using fasting (18)F-FDG PET/MRI. Although this novel biosignal correlates with long-term functional outcome, the corresponding cellular substrate is not well understood. ...Taken together, the findings from this analysi …
Myocardial inflammation can be visualized in patients using fasting (18)F-FDG PET/MRI. Although this novel biosignal correlates with long- …
Incomplete echocardiographic recovery at 6 months predicts long-term sequelae after intermediate-risk pulmonary embolism. A post-hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial.
Barco S, Russo M, Vicaut E, Becattini C, Bertoletti L, Beyer-Westendorf J, Bouvaist H, Couturaud F, Danays T, Dellas C, Duerschmied D, Empen K, Ferrari E, Galiè N, Jiménez D, Klok FA, Kostrubiec M, Kozak M, Kupatt C, Lang IM, Lankeit M, Meneveau N, Palazzini M, Pruszczyk P, Rugolotto M, Salvi A, Sanchez O, Schellong S, Sobkowicz B, Meyer G, Konstantinides SV. Barco S, et al. Among authors: kupatt c. Clin Res Cardiol. 2019 Jul;108(7):772-778. doi: 10.1007/s00392-018-1405-1. Epub 2018 Dec 18. Clin Res Cardiol. 2019. PMID: 30564950 Free PMC article. Clinical Trial.
METHODS: In a post hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial, we focused on 219 survivors of acute intermediate-risk PE with clinical and echocardiographic follow-up 6 months after randomisation as well as over the long term (median, 3 years after …
METHODS: In a post hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial, we focused on 219 survivors of acute intermediate-ris …
Consistent success in life-supporting porcine cardiac xenotransplantation.
Längin M, Mayr T, Reichart B, Michel S, Buchholz S, Guethoff S, Dashkevich A, Baehr A, Egerer S, Bauer A, Mihalj M, Panelli A, Issl L, Ying J, Fresch AK, Buttgereit I, Mokelke M, Radan J, Werner F, Lutzmann I, Steen S, Sjöberg T, Paskevicius A, Qiuming L, Sfriso R, Rieben R, Dahlhoff M, Kessler B, Kemter E, Kurome M, Zakhartchenko V, Klett K, Hinkel R, Kupatt C, Falkenau A, Reu S, Ellgass R, Herzog R, Binder U, Wich G, Skerra A, Ayares D, Kind A, Schönmann U, Kaup FJ, Hagl C, Wolf E, Klymiuk N, Brenner P, Abicht JM. Längin M, et al. Among authors: kupatt c. Nature. 2018 Dec;564(7736):430-433. doi: 10.1038/s41586-018-0765-z. Epub 2018 Dec 5. Nature. 2018. PMID: 30518863
Genetically multi-modified pig hearts that lack galactose-alpha1,3-galactose epitopes (alpha1,3-galactosyltransferase knockout) and express a human membrane cofactor protein (CD46) and human thrombomodulin have survived for up to 945 days after heterotopic abdominal transplantati …
Genetically multi-modified pig hearts that lack galactose-alpha1,3-galactose epitopes (alpha1,3-galactosyltransferase knockout) and express …
21 results