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Year Number of Results
1997 1
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2004 1
2005 1
2007 1
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2012 2
2017 1
2018 4
2019 3
2020 2
2022 2
2023 2
2024 0

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Page 1
Impact of Thrombolytic Therapy on the Long-Term Outcome of Intermediate-Risk Pulmonary Embolism.
Konstantinides SV, Vicaut E, Danays T, Becattini C, Bertoletti L, Beyer-Westendorf J, Bouvaist H, Couturaud F, Dellas C, Duerschmied D, Empen K, Ferrari E, Galiè N, Jiménez D, Kostrubiec M, Kozak M, Kupatt C, Lang IM, Lankeit M, Meneveau N, Palazzini M, Pruszczyk P, Rugolotto M, Salvi A, Sanchez O, Schellong S, Sobkowicz B, Meyer G. Konstantinides SV, et al. Among authors: kupatt c. J Am Coll Cardiol. 2017 Mar 28;69(12):1536-1544. doi: 10.1016/j.jacc.2016.12.039. J Am Coll Cardiol. 2017. PMID: 28335835 Free article. Clinical Trial.
BACKGROUND: The long-term effect of thrombolytic treatment of pulmonary embolism (PE) is unknown. ...RESULTS: Long-term (median 37.8 months) survival was assessed in 353 of 359 (98.3%) patients in the thrombolysis arm and in 343 of 350 (98.0%) in the placebo arm. .. …
BACKGROUND: The long-term effect of thrombolytic treatment of pulmonary embolism (PE) is unknown. ...RESULTS: Long-term (media …
Five-Year Outcomes after PCI or CABG for Left Main Coronary Disease.
Stone GW, Kappetein AP, Sabik JF, Pocock SJ, Morice MC, Puskas J, Kandzari DE, Karmpaliotis D, Brown WM 3rd, Lembo NJ, Banning A, Merkely B, Horkay F, Boonstra PW, van Boven AJ, Ungi I, Bogáts G, Mansour S, Noiseux N, Sabaté M, Pomar J, Hickey M, Gershlick A, Buszman PE, Bochenek A, Schampaert E, Pagé P, Modolo R, Gregson J, Simonton CA, Mehran R, Kosmidou I, Généreux P, Crowley A, Dressler O, Serruys PW; EXCEL Trial Investigators. Stone GW, et al. N Engl J Med. 2019 Nov 7;381(19):1820-1830. doi: 10.1056/NEJMoa1909406. Epub 2019 Sep 28. N Engl J Med. 2019. PMID: 31562798 Free article. Clinical Trial.
BACKGROUND: Long-term outcomes after percutaneous coronary intervention (PCI) with contemporary drug-eluting stents, as compared with coronary-artery bypass grafting (CABG), in patients with left main coronary artery disease are not clearly established. ...
BACKGROUND: Long-term outcomes after percutaneous coronary intervention (PCI) with contemporary drug-eluting stents, as compared with …
Endothelial Retargeting of AAV9 In Vivo.
Bozoglu T, Lee S, Ziegler T, Jurisch V, Maas S, Baehr A, Hinkel R, Hoenig A, Hariharan A, Kim CI, Decker S, Sami H, Koppara T, Oellinger R, Müller OJ, Frank D, Megens R, Nelson P, Weber C, Schnieke A, Sperandio M, Santamaria G, Rad R, Moretti A, Laugwitz KL, Soehnlein O, Ogris M, Kupatt C. Bozoglu T, et al. Among authors: kupatt c. Adv Sci (Weinh). 2022 Mar;9(7):e2103867. doi: 10.1002/advs.202103867. Epub 2022 Jan 12. Adv Sci (Weinh). 2022. PMID: 35023328 Free PMC article.
Functionally, G2(CNN) AAV9-S1FG mediates S1FG-leukocyte adhesion, whereas G2(CNN) AAV9-Anxa1-application reduces long-term leukocyte recruitment. Moreover, blood pressure increases in Cas9-expressing mice subjected to G2(CNN) AAV9-gRNA(eNOS) . ...
Functionally, G2(CNN) AAV9-S1FG mediates S1FG-leukocyte adhesion, whereas G2(CNN) AAV9-Anxa1-application reduces long-term leukocyte …
Consistent success in life-supporting porcine cardiac xenotransplantation.
Längin M, Mayr T, Reichart B, Michel S, Buchholz S, Guethoff S, Dashkevich A, Baehr A, Egerer S, Bauer A, Mihalj M, Panelli A, Issl L, Ying J, Fresch AK, Buttgereit I, Mokelke M, Radan J, Werner F, Lutzmann I, Steen S, Sjöberg T, Paskevicius A, Qiuming L, Sfriso R, Rieben R, Dahlhoff M, Kessler B, Kemter E, Kurome M, Zakhartchenko V, Klett K, Hinkel R, Kupatt C, Falkenau A, Reu S, Ellgass R, Herzog R, Binder U, Wich G, Skerra A, Ayares D, Kind A, Schönmann U, Kaup FJ, Hagl C, Wolf E, Klymiuk N, Brenner P, Abicht JM. Längin M, et al. Among authors: kupatt c. Nature. 2018 Dec;564(7736):430-433. doi: 10.1038/s41586-018-0765-z. Epub 2018 Dec 5. Nature. 2018. PMID: 30518863
Genetically multi-modified pig hearts that lack galactose-alpha1,3-galactose epitopes (alpha1,3-galactosyltransferase knockout) and express a human membrane cofactor protein (CD46) and human thrombomodulin have survived for up to 945 days after heterotopic abdominal transplantati …
Genetically multi-modified pig hearts that lack galactose-alpha1,3-galactose epitopes (alpha1,3-galactosyltransferase knockout) and express …
Coronary Angiography After Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation: One-Year Outcomes of a Randomized Clinical Trial.
Desch S, Freund A, Akin I, Behnes M, Preusch MR, Zelniker TA, Skurk C, Landmesser U, Graf T, Eitel I, Fuernau G, Haake H, Nordbeck P, Hammer F, Felix SB, Hassager C, Kjærgaard J, Fichtlscherer S, Ledwoch J, Lenk K, Joner M, Steiner S, Liebetrau C, Voigt I, Zeymer U, Brand M, Schmitz R, Horstkotte J, Jacobshagen C, Pöss J, Abdel-Wahab M, Lurz P, Jobs A, de Waha S, Olbrich D, Sandig F, König IR, Brett S, Vens M, Klinge K, Thiele H; TOMAHAWK Investigators. Desch S, et al. JAMA Cardiol. 2023 Sep 1;8(9):827-834. doi: 10.1001/jamacardio.2023.2264. JAMA Cardiol. 2023. PMID: 37556123
IMPORTANCE: Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest (OHCA). The long-term effect of early coronary angiography on patients with OHCA with possible coronary trigger but no ST-segment elevation remains unclear. ...
IMPORTANCE: Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest (OHCA). The long-term effect of early coronar …
Thymosin β4-mediated protective effects in the heart.
Hinkel R, Klett K, Bähr A, Kupatt C. Hinkel R, et al. Among authors: kupatt c. Expert Opin Biol Ther. 2018 Jul;18(sup1):121-129. doi: 10.1080/14712598.2018.1490409. Expert Opin Biol Ther. 2018. PMID: 30063857 Review.
EXPERT OPINION: Induction of mature micro-vessels is a prerequisite for chronic myocardial ischemia and might be achieved via a long-term overexpression of Thymosin beta4....
EXPERT OPINION: Induction of mature micro-vessels is a prerequisite for chronic myocardial ischemia and might be achieved via a long-term …
Translational Aspects of Adeno-Associated Virus-Mediated Cardiac Gene Therapy.
Ziegler T, Ishikawa K, Hinkel R, Kupatt C. Ziegler T, et al. Among authors: kupatt c. Hum Gene Ther. 2018 Dec;29(12):1341-1351. doi: 10.1089/hum.2017.229. Epub 2018 Jul 24. Hum Gene Ther. 2018. PMID: 29848073 Review.
Specifically, for cardiovascular gene therapy, rAAVs appear superior to other vector systems such as lenti- and adenoviral vectors due to the ease of accomplishing long-term cardiac expression of target genes and the reduced risk of provoking immune responses or triggering …
Specifically, for cardiovascular gene therapy, rAAVs appear superior to other vector systems such as lenti- and adenoviral vectors due to th …
Interdependence of Angiogenesis and Arteriogenesis in Development and Disease.
le Noble F, Kupatt C. le Noble F, et al. Among authors: kupatt c. Int J Mol Sci. 2022 Mar 31;23(7):3879. doi: 10.3390/ijms23073879. Int J Mol Sci. 2022. PMID: 35409246 Free PMC article. Review.
We provide evidence showing that this loss of synchronization reduces arterial collateral network recruitment upon arterial stenosis, and the long-term clinical outcome of current revascularization strategies in these patient cohorts. We describe mechanisms and signals con …
We provide evidence showing that this loss of synchronization reduces arterial collateral network recruitment upon arterial stenosis, and th …
Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52.
Stirm M, Shashikadze B, Blutke A, Kemter E, Lange A, Stöckl JB, Jaudas F, Laane L, Kurome M, Keßler B, Zakhartchenko V, Bähr A, Klymiuk N, Nagashima H, Walter MC, Wurst W, Kupatt C, Fröhlich T, Wolf E. Stirm M, et al. Among authors: kupatt c. Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2301250120. doi: 10.1073/pnas.2301250120. Epub 2023 Jul 10. Proc Natl Acad Sci U S A. 2023. PMID: 37428903 Free PMC article.
Our findings indicate that ubiquitous deletion of DMD exon 51 in DMDdelta52 pigs largely rescues the rapidly progressing, severe muscular dystrophy and the reduced cardiac function of this model. Long-term follow-up studies of DMDdelta51-52 pigs will show if they develop s …
Our findings indicate that ubiquitous deletion of DMD exon 51 in DMDdelta52 pigs largely rescues the rapidly progressing, severe muscular dy …
Agrin Promotes Coordinated Therapeutic Processes Leading to Improved Cardiac Repair in Pigs.
Baehr A, Umansky KB, Bassat E, Jurisch V, Klett K, Bozoglu T, Hornaschewitz N, Solyanik O, Kain D, Ferraro B, Cohen-Rabi R, Krane M, Cyran C, Soehnlein O, Laugwitz KL, Hinkel R, Kupatt C, Tzahor E. Baehr A, et al. Among authors: kupatt c. Circulation. 2020 Sep;142(9):868-881. doi: 10.1161/CIRCULATIONAHA.119.045116. Epub 2020 Jun 8. Circulation. 2020. PMID: 32508131
A single dose of recombinant human agrin improved heart function, infarct size, fibrosis, and adverse remodeling parameters 28 days after MI. Short-term MI experiments along with complementary murine studies revealed myocardial protection, improved angiogenesis, inflammato …
A single dose of recombinant human agrin improved heart function, infarct size, fibrosis, and adverse remodeling parameters 28 days after MI …
21 results