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Angiogenic Self-Assembling Peptide Scaffolds for Functional Tissue Regeneration.
Sarkar B, Nguyen PK, Gao W, Dondapati A, Siddiqui Z, Kumar VA. Sarkar B, et al. Among authors: kumar va. Biomacromolecules. 2018 Sep 10;19(9):3597-3611. doi: 10.1021/acs.biomac.8b01137. Epub 2018 Aug 29. Biomacromolecules. 2018. PMID: 30132656 Review.
These peptides may be implanted in vivo at the site of ischemia, bypassing the first-pass metabolism and enabling long-term retention and sustained efficacy. Mimics of angiogenic proteins show tremendous potential for clinical use. ...
These peptides may be implanted in vivo at the site of ischemia, bypassing the first-pass metabolism and enabling long-term retention …
Implantable anti-angiogenic scaffolds for treatment of neovascular ocular pathologies.
Sarkar B, Siddiqui Z, Kim KK, Nguyen PK, Reyes X, McGill TJ, Kumar VA. Sarkar B, et al. Among authors: kumar va. Drug Deliv Transl Res. 2020 Oct;10(5):1191-1202. doi: 10.1007/s13346-020-00753-0. Drug Deliv Transl Res. 2020. PMID: 32232681 Free PMC article. Review.
We discuss recent developments for the treatment of these diseases, including bioactive tissue-engineered materials, which may reduce frequency of dosage and propose a path forward for improving patient outcomes. Graphical abstract Development of materials for long-term in …
We discuss recent developments for the treatment of these diseases, including bioactive tissue-engineered materials, which may reduce freque …
Self-Assembling Peptides with Insulin-Like Growth Factor Mimicry.
Roy A, Dodd-O JB, Robang AS, He D, West O, Siddiqui Z, Aguas ED, Goldberg H, Griffith A, Heffernan C, Hu Y, Paravastu AK, Kumar VA. Roy A, et al. Among authors: kumar va. ACS Appl Mater Interfaces. 2024 Jan 10;16(1):364-375. doi: 10.1021/acsami.3c15660. Epub 2023 Dec 25. ACS Appl Mater Interfaces. 2024. PMID: 38145951
Furthermore, infiltrated hydrogels are stable for weeks to months. We conclude that the enhanced targeting and long-term stability of our SAP/GF mimicry implants may improve the efficacy and safety of future GF mimic therapeutics....
Furthermore, infiltrated hydrogels are stable for weeks to months. We conclude that the enhanced targeting and long-term stability of …
In vivo Neuroprotective Effect of a Self-assembled Peptide Hydrogel.
Sarkar B, Ma X, Agas A, Siddiqui Z, Iglesias-Montoro P, Nguyen PK, Kim KK, Haorah J, Kumar VA. Sarkar B, et al. Among authors: kumar va. Chem Eng J. 2021 Mar 15;408:127295. doi: 10.1016/j.cej.2020.127295. Epub 2020 Oct 9. Chem Eng J. 2021. PMID: 37842134 Free PMC article.
Traumatic brain injury (TBI) is associated with poor intrinsic healing responses and long-term cognitive decline. A major pathological outcome of TBI is acute glutamate-mediated excitotoxicity (GME) experienced by neurons. ...Further work is needed to evaluate less invasiv …
Traumatic brain injury (TBI) is associated with poor intrinsic healing responses and long-term cognitive decline. A major pathologica …
Drug-triggered and cross-linked self-assembling nanofibrous hydrogels.
Kumar VA, Shi S, Wang BK, Li IC, Jalan AA, Sarkar B, Wickremasinghe NC, Hartgerink JD. Kumar VA, et al. J Am Chem Soc. 2015 Apr 15;137(14):4823-30. doi: 10.1021/jacs.5b01549. Epub 2015 Apr 1. J Am Chem Soc. 2015. PMID: 25831137 Free PMC article.
In this study, we demonstrate this process of ionic cross-linking of peptides using multivalent drugs to create hydrogels for sustained long-term delivery of drugs. Using phosphate, heparin, clodronate, trypan, and suramin, we demonstrate the utility of this strategy. ...O …
In this study, we demonstrate this process of ionic cross-linking of peptides using multivalent drugs to create hydrogels for sustained long …
Preclinical Efficacy of Pro- and Anti-Angiogenic Peptide Hydrogels to Treat Age-Related Macular Degeneration.
Acevedo-Jake A, Shi S, Siddiqui Z, Sanyal S, Schur R, Kaja S, Yuan A, Kumar VA. Acevedo-Jake A, et al. Among authors: kumar va. Bioengineering (Basel). 2021 Nov 23;8(12):190. doi: 10.3390/bioengineering8120190. Bioengineering (Basel). 2021. PMID: 34940343 Free PMC article.
Unexpectedly, treatment with pro-angiogenic peptide hydrogel showed significant, immediate improvement in reducing vascular leak; in the short term, the pro-angiogenic peptide performed better than anti-angiogenic peptide hydrogel and was comparable to Aflibercept. ...Base …
Unexpectedly, treatment with pro-angiogenic peptide hydrogel showed significant, immediate improvement in reducing vascular leak; in the sho …
Inhalation Dose and Source Term Studies in a Tribal Area of Wayanad, Kerala, India.
Bhaskaran R, Damodaran RC, Kumar VA, Panakal John J, Bangaru D, Natarajan C, Sathiamurthy BS, Mundiyanikal Thomas J, Mishra R. Bhaskaran R, et al. Among authors: kumar va. J Environ Public Health. 2017;2017:1930787. doi: 10.1155/2017/1930787. Epub 2017 May 22. J Environ Public Health. 2017. PMID: 28611847 Free PMC article.
Progeny concentration of radon and thoron and the diurnal variation of radon were also studied. In order to assess source term, wall and floor exhalation studies have been done for the houses showing elevated concentration of radon and thoron. ...
Progeny concentration of radon and thoron and the diurnal variation of radon were also studied. In order to assess source term, wall …
Seasonal characteristics of boundary layer over a high-altitude rural site in Western India: implications on dispersal of particulate matter.
Aslam MY, Mukherjee S, Kumar VA, Patil RD, Patil SS, Dudhambe SD, Saha SK, Pandithurai G. Aslam MY, et al. Among authors: kumar va. Environ Sci Pollut Res Int. 2021 Jul;28(26):35266-35277. doi: 10.1007/s11356-021-13163-7. Epub 2021 Mar 5. Environ Sci Pollut Res Int. 2021. PMID: 33666849
In contrast, cold and moist air mass during the monsoon season enhances the wind shear with lower buoyancy term which results in lowering of PBLH. The comparison of PBLH between MWR and radiosonde observations shows a good correlation (r(2) = 0.66, p=0.001). ...
In contrast, cold and moist air mass during the monsoon season enhances the wind shear with lower buoyancy term which results in lowe …
Speech and Swallowing Function Outcome Following Early Tracheostomy in Patients Who Underwent Neurosurgical Intervention.
Kumar VA, Reddy BU, Kiran Kumar VA, Pal R, Kumar RL, Jahnavi M, Agrawal A. Kumar VA, et al. Indian J Crit Care Med. 2018 Jun;22(6):427-430. doi: 10.4103/ijccm.IJCCM_31_18. Indian J Crit Care Med. 2018. PMID: 29962743 Free PMC article.
CONCLUSIONS: Our study suggested that though, majority of neurotrauma patients require tracheostomy for long term ventilator support and associated speech and swallowing problems are expected....
CONCLUSIONS: Our study suggested that though, majority of neurotrauma patients require tracheostomy for long term ventilator support …
Lorazepam-induced Short-term Remission of Symptoms in a Case of Paranoid Schizophrenia.
Parkar SR, Dhuri C, Kumar VA. Parkar SR, et al. Among authors: kumar va. Indian J Psychol Med. 2011 Jul;33(2):205-7. doi: 10.4103/0253-7176.92053. Indian J Psychol Med. 2011. PMID: 22345853 Free PMC article.
Here, we are reporting a case of an elderly female patient with chronic paranoid schizophrenia showing short-term remission in paranoid symptoms with injectable lorazepam....
Here, we are reporting a case of an elderly female patient with chronic paranoid schizophrenia showing short-term remission in parano …
11 results