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Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction.
Prather AA, Gao Y, Betancourt L, Kordahl RC, Sriram A, Huang CY, Hays SR, Kukreja J, Calabrese DR, Venado A, Kapse B, Greenland JR, Singer JP. Prather AA, et al. Among authors: kukreja j. medRxiv [Preprint]. 2024 Jan 23:2023.10.12.23296973. doi: 10.1101/2023.10.12.23296973. medRxiv. 2024. PMID: 37873197 Free PMC article. Preprint.
Many lung transplant recipients fail to derive the expected improvements in functioning, HRQL, or long-term survival. Sleep may represent an important, albeit rarely examined, factor influencing lung transplant outcomes. ...
Many lung transplant recipients fail to derive the expected improvements in functioning, HRQL, or long-term survival. Sleep may repre …
CD16+ natural killer cells in bronchoalveolar lavage are associated with antibody-mediated rejection and chronic lung allograft dysfunction.
Calabrese DR, Chong T, Singer JP, Rajalingam R, Hays SR, Kukreja J, Leard L, Golden JA, Lanier LL, Greenland JR. Calabrese DR, et al. Among authors: kukreja j. Am J Transplant. 2023 Jan;23(1):37-44. doi: 10.1016/j.ajt.2022.10.006. Epub 2023 Jan 11. Am J Transplant. 2023. PMID: 36695619 Free PMC article.
Acute and chronic rejections limit the long-term survival after lung transplant. Pulmonary antibody-mediated rejection (AMR) is an incompletely understood driver of long-term outcomes characterized by donor-specific antibodies (DSAs), innate immune infiltration, and …
Acute and chronic rejections limit the long-term survival after lung transplant. Pulmonary antibody-mediated rejection (AMR) is an in …
Early Postoperative Management of Lung Transplant Recipients.
Trinh BN, Brzezinski M, Kukreja J. Trinh BN, et al. Among authors: kukreja j. Thorac Surg Clin. 2022 May;32(2):185-195. doi: 10.1016/j.thorsurg.2021.11.006. Thorac Surg Clin. 2022. PMID: 35512937 Review.
Prompt recognition and treatment of primary graft dysfunction can alter long-term allograft function. Cardiovascular, gastrointestinal, renal, and hematologic derangements are common and require close management to limit their negative sequelae....
Prompt recognition and treatment of primary graft dysfunction can alter long-term allograft function. Cardiovascular, gastrointestina …
Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction.
Dugger DT, Calabrese DR, Gao Y, Deiter F, Tsao T, Maheshwari J, Hays SR, Leard L, Kleinhenz ME, Shah R, Golden J, Kukreja J, Gordon ED, Singer JP, Greenland JR. Dugger DT, et al. Among authors: kukreja j. Front Immunol. 2021 Oct 7;12:704172. doi: 10.3389/fimmu.2021.704172. eCollection 2021. Front Immunol. 2021. PMID: 34691018 Free PMC article.
These data show how PGD might suppress key promoter methylation resulting in long-term impacts on the allograft....
These data show how PGD might suppress key promoter methylation resulting in long-term impacts on the allograft....
Lung Transplantation for Patients With COVID-19.
King CS, Mannem H, Kukreja J, Aryal S, Tang D, Singer JP, Bharat A, Behr J, Nathan SD. King CS, et al. Among authors: kukreja j. Chest. 2022 Jan;161(1):169-178. doi: 10.1016/j.chest.2021.08.041. Epub 2021 Aug 19. Chest. 2022. PMID: 34418410 Free PMC article. Review.
Others may develop post-COVID fibrosis, resulting in substantial disability and need for long-term supplemental oxygen. In both of these situations, treatment teams often inquire about the possibility of lung transplantation. ...
Others may develop post-COVID fibrosis, resulting in substantial disability and need for long-term supplemental oxygen. In both of th …
Lung transplantation from swimming pool drowning victims: A case series.
Tsou S, Chen J, Brzezinski M, Hays S, Leard L, Singer JP, Trinh B, Kukreja J. Tsou S, et al. Among authors: kukreja j. Am J Transplant. 2021 Jun;21(6):2273-2278. doi: 10.1111/ajt.16510. Epub 2021 Feb 25. Am J Transplant. 2021. PMID: 33508883 Free article.
Here, we describe three cases of bilateral lung transplantation from donors who drowned in swimming pools, with good short- and long-term outcomes. These cases lend further evidence to the feasibility of using such organs that have traditionally been viewed with much trepi …
Here, we describe three cases of bilateral lung transplantation from donors who drowned in swimming pools, with good short- and long-term …
Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection.
Dugger DT, Fung M, Zlock L, Caldera S, Sharp L, Hays SR, Singer JP, Leard LE, Golden JA, Shah RJ, Kukreja J, Gordon E, Finkbeiner W, Kleinhenz ME, Langelier C, Greenland JR. Dugger DT, et al. Among authors: kukreja j. Cell Rep Med. 2020 Jul 21;1(4):100055. doi: 10.1016/j.xcrm.2020.100055. Cell Rep Med. 2020. PMID: 32754722 Free PMC article.
Lung transplantation can be lifesaving in end-stage cystic fibrosis (CF), but long-term survival is limited by chronic lung allograft dysfunction (CLAD). ...
Lung transplantation can be lifesaving in end-stage cystic fibrosis (CF), but long-term survival is limited by chronic lung allograft …
Airway Epithelial Telomere Dysfunction Drives Remodeling Similar to Chronic Lung Allograft Dysfunction.
Naikawadi RP, Green G, Jones KD, Achtar-Zadeh N, Mieleszko JE, Arnould I, Kukreja J, Greenland JR, Wolters PJ. Naikawadi RP, et al. Among authors: kukreja j. Am J Respir Cell Mol Biol. 2020 Oct;63(4):490-501. doi: 10.1165/rcmb.2019-0374OC. Am J Respir Cell Mol Biol. 2020. PMID: 32551854 Free PMC article.
Telomere dysfunction is associated with multiple fibrotic lung processes, including chronic lung allograft dysfunction (CLAD)-the major limitation to long-term survival following lung transplantation. Although shorter donor telomere lengths are associated with an increased …
Telomere dysfunction is associated with multiple fibrotic lung processes, including chronic lung allograft dysfunction (CLAD)-the major limi …
Redefining marginality: donor lung criteria.
Kukreja J, Chen J, Brzezinski M. Kukreja J, et al. Curr Opin Organ Transplant. 2020 Jun;25(3):280-284. doi: 10.1097/MOT.0000000000000764. Curr Opin Organ Transplant. 2020. PMID: 32304425 Review.
SUMMARY: The decision to use such organs, including those with smoking history, should be taken in totality weighing both donor and recipient characteristics. Hence, authors would advocate removing the term 'marginal' or 'extended' from lung donor criteria....
SUMMARY: The decision to use such organs, including those with smoking history, should be taken in totality weighing both donor and recipien …
Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study.
Warnecke G, Van Raemdonck D, Smith MA, Massard G, Kukreja J, Rea F, Loor G, De Robertis F, Nagendran J, Dhital KK, Moradiellos Díez FJ, Knosalla C, Bermudez CA, Tsui S, McCurry K, Wang IW, Deuse T, Lesèche G, Thomas P, Tudorache I, Kühn C, Avsar M, Wiegmann B, Sommer W, Neyrinck A, Schiavon M, Calabrese F, Santelmo N, Olland A, Falcoz PE, Simon AR, Varela A, Madsen JC, Hertz M, Haverich A, Ardehali A. Warnecke G, et al. Among authors: kukreja j. Lancet Respir Med. 2018 May;6(5):357-367. doi: 10.1016/S2213-2600(18)30136-X. Epub 2018 Apr 9. Lancet Respir Med. 2018. PMID: 29650408 Clinical Trial.
INTERPRETATION: The INSPIRE trial met its primary effectiveness and safety endpoints. Although no short-term survival benefit was reported, further research is needed to see whether the reduced incidence of PGD3 within 72 h of a transplant might translate into earlier reco …
INTERPRETATION: The INSPIRE trial met its primary effectiveness and safety endpoints. Although no short-term survival benefit was rep …
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