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Young-onset colorectal cancer.
Spaander MCW, Zauber AG, Syngal S, Blaser MJ, Sung JJ, You YN, Kuipers EJ. Spaander MCW, et al. Among authors: kuipers ej. Nat Rev Dis Primers. 2023 Apr 27;9(1):21. doi: 10.1038/s41572-023-00432-7. Nat Rev Dis Primers. 2023. PMID: 37105987 Free PMC article. Review.
Owing to a lack of screening, patients with YO-CRC are often diagnosed with advanced-stage disease. Long-term treatment-related complications should be taken into account in these younger patients, making the more traditional sequential approaches of drug therapy not alway …
Owing to a lack of screening, patients with YO-CRC are often diagnosed with advanced-stage disease. Long-term treatment-related compl …
Levothyroxine use and the risk of colorectal cancer: a large population-based case-control study.
Kuiper JG, Fenneman AC, van der Spek AH, Rampanelli E, Nieuwdorp M, van Herk-Sukel MPP, Lemmens VEPP, Kuipers EJ, Herings RMC, Fliers E. Kuiper JG, et al. Among authors: kuipers ej. Endocr Connect. 2022 Jan 20;11(1):e210463. doi: 10.1530/EC-21-0463. Endocr Connect. 2022. PMID: 34860178 Free PMC article.
RESULTS: A total of 1066 colorectal cancer patients (4%) and 4024 (4%) controls had used levothyroxine at any point before index date (adjusted odds ratio 0.95 (0.88-1.01)). Long-term use of levothyroxine was seen in 323 (30%) colorectal cancer patients and 1111 (28%) cont …
RESULTS: A total of 1066 colorectal cancer patients (4%) and 4024 (4%) controls had used levothyroxine at any point before index date (adjus …
A population-based linked cohort of cancer and primary care data: A new source to study the management of cancer in primary care.
Kuiper JG, van Herk-Sukel MPP, Lemmens VEPP, Kuipers EJ, Herings RMC. Kuiper JG, et al. Among authors: kuipers ej. Eur J Cancer Care (Engl). 2022 Jan;31(1):e13529. doi: 10.1111/ecc.13529. Epub 2021 Oct 17. Eur J Cancer Care (Engl). 2022. PMID: 34658095 Free PMC article.
CONCLUSION: The NCR-PHARMO GP cohort provides rich data on the primary care management of cancer facilitating large-scale observational cancer research in the primary care setting. The patient-level linkage allows for long-term follow-up of cancer patients, with ongoing an …
CONCLUSION: The NCR-PHARMO GP cohort provides rich data on the primary care management of cancer facilitating large-scale observational canc …
Longitudinal symptomatic interactions in long-standing schizophrenia: a novel five-point analysis based on directed acyclic graphs.
Moffa G, Kuipers J, Carrà G, Crocamo C, Kuipers E, Angermeyer M, Brugha T, Toumi M, Bebbington P. Moffa G, et al. Among authors: kuipers e. Psychol Med. 2023 Mar;53(4):1371-1378. doi: 10.1017/S0033291721002920. Epub 2021 Aug 5. Psychol Med. 2023. PMID: 34348816 Free PMC article.
RESULTS: Our DAG analysis suggests that the main drivers of symptoms in this long-term sample were delusions and paranoid thinking. These led to affective disturbance, not vice versa as we initially predicted. ...
RESULTS: Our DAG analysis suggests that the main drivers of symptoms in this long-term sample were delusions and paranoid thinking. T …
Conditionally immortalized brown preadipocytes can switch between proliferative and differentiated states.
Liu J, Kuipers EN, Sips HCM, Dorleijn JC, van Dam AD, Christodoulides C, Karpe F, Zhou G, Boon MR, Rensen PCN, de Vries AAF, Kooijman S. Liu J, et al. Among authors: kuipers en. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Dec;1864(12):158511. doi: 10.1016/j.bbalip.2019.08.007. Epub 2019 Aug 26. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 31465889 Free article.
In the presence of doxycycline, both the murine and human cell lines showed long-term proliferation capacity with a population doubling time of ~28 h. ...
In the presence of doxycycline, both the murine and human cell lines showed long-term proliferation capacity with a population doubli …
A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice.
Kuipers EN, Held NM, In Het Panhuis W, Modder M, Ruppert PMM, Kersten S, Kooijman S, Guigas B, Houtkooper RH, Rensen PCN, Boon MR. Kuipers EN, et al. Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E820-E830. doi: 10.1152/ajpendo.00123.2019. Epub 2019 Aug 6. Am J Physiol Endocrinol Metab. 2019. PMID: 31386566 Free article.
Brown adipose tissue (BAT) catabolizes glucose and fatty acids to produce heat and thereby contributes to energy expenditure. Long-term high-fat diet (HFD) feeding results in so-called 'whitening' of BAT characterized by increased lipid deposition, mitochondrial dysfunctio …
Brown adipose tissue (BAT) catabolizes glucose and fatty acids to produce heat and thereby contributes to energy expenditure. Long-term …
Percutaneous endoscopic gastrostomy in older patients with and without dementia: Survival and ethical considerations.
van Bruchem-Visser RL, Mattace-Raso FUS, de Beaufort ID, Kuipers EJ. van Bruchem-Visser RL, et al. Among authors: kuipers ej. J Gastroenterol Hepatol. 2019 Apr;34(4):736-741. doi: 10.1111/jgh.14573. Epub 2019 Jan 8. J Gastroenterol Hepatol. 2019. PMID: 30551264
RESULTS: Three-hundred-and-three patients were included, mean age of 77.4 years. Forty-two (13.9%) patients had dementia. Short-term complications did not differ between patients with and without cognitive disorders (P 0.224). ...
RESULTS: Three-hundred-and-three patients were included, mean age of 77.4 years. Forty-two (13.9%) patients had dementia. Short-term …
Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation.
Held NM, Kuipers EN, van Weeghel M, van Klinken JB, Denis SW, Lombès M, Wanders RJ, Vaz FM, Rensen PCN, Verhoeven AJ, Boon MR, Houtkooper RH. Held NM, et al. Among authors: kuipers en. Sci Rep. 2018 Jun 22;8(1):9562. doi: 10.1038/s41598-018-27875-3. Sci Rep. 2018. PMID: 29934543 Free PMC article.
Collectively, we show that while fatty acids are the main substrates for oxidation, glucose is also oxidized to meet the increased energy demand during short term beta3-AR activation. PDH plays an important role in directing glucose carbons towards oxidation....
Collectively, we show that while fatty acids are the main substrates for oxidation, glucose is also oxidized to meet the increased energy de …
Natural History of Barrett's Esophagus.
Kuipers EJ, Spaander MC. Kuipers EJ, et al. Dig Dis Sci. 2018 Aug;63(8):1997-2004. doi: 10.1007/s10620-018-5161-x. Dig Dis Sci. 2018. PMID: 29905908 Free PMC article. Review.
This results from many cross-sectional and cohort studies, many describing patients undergoing long-term surveillance. Their consent to use their clinical data has improved our knowledge to the benefit of these same and other patients. ...
This results from many cross-sectional and cohort studies, many describing patients undergoing long-term surveillance. Their consent …
The Coping with Unusual Experiences for Children Study (CUES): A pilot randomized controlled evaluation of the acceptability and potential clinical utility of a cognitive behavioural intervention package for young people aged 8-14 years with unusual experiences and emotional symptoms.
Jolley S, Kuipers E, Stewart C, Browning S, Bracegirdle K, Basit N, Gin K, Hirsch C, Corrigall R, Banerjea P, Turley G, Stahl D, Laurens KR. Jolley S, et al. Among authors: kuipers e. Br J Clin Psychol. 2018 Sep;57(3):328-350. doi: 10.1111/bjc.12176. Epub 2018 Mar 12. Br J Clin Psychol. 2018. PMID: 29527754 Clinical Trial.
This is a pilot study, and further evaluation is needed. Longer term outcomes should be a focus of future evaluation....
This is a pilot study, and further evaluation is needed. Longer term outcomes should be a focus of future evaluation....
99 results