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Incidence of nephrotoxicity with prolonged aminoglycoside exposure in patients with cystic fibrosis.
Saad A, Young MR, Studtmann AE, Autry EB, Schadler A, Beckman EJ, Gardner BM, Wurth MA, Kuhn RJ. Saad A, et al. Among authors: kuhn rj. Pediatr Pulmonol. 2020 Dec;55(12):3384-3390. doi: 10.1002/ppul.25066. Epub 2020 Oct 23. Pediatr Pulmonol. 2020. PMID: 32910553
The baseline and final estimated glomerular filtration rate (eGFR) were calculated to assess long-term effects on renal function. Sixty-six patients, representing greater than 700 courses, were included in the final analysis. ...Cumulative exposure to IV aminoglycosides in …
The baseline and final estimated glomerular filtration rate (eGFR) were calculated to assess long-term effects on renal function. Six …
Hypertonic saline treatment of cystic fibrosis.
Taylor LM, Kuhn RJ. Taylor LM, et al. Among authors: kuhn rj. Ann Pharmacother. 2007 Mar;41(3):481-4. doi: 10.1345/aph.1H425. Epub 2007 Feb 27. Ann Pharmacother. 2007. PMID: 17327291 Review.
HS has been shown to improve mucociliary clearance versus placebo. A short-term efficacy trial showed a modest and variable increase in forced expiratory volume in 1 second (FEV(1)) over a 2 week period (15.0 +/- 16.0% from baseline vs 2.8 +/- 13.1% with HS 6% and NaCl 0.9 …
HS has been shown to improve mucociliary clearance versus placebo. A short-term efficacy trial showed a modest and variable increase …
Treating the asthmatic child with dry powder inhalers: a possible breakthrough.
Schoelles-Williams J, Kuhn RJ. Schoelles-Williams J, et al. Among authors: kuhn rj. Pediatr Nurs. 1999 Jul-Aug;25(4):433-5, 455. Pediatr Nurs. 1999. PMID: 12024364
In the last decade, advances in both oral and inhalation therapy have expanded the long-term control options available to these patients. Inhalation therapy has received increased attention during this period due to the fact that this method of therapy is convenient, nonin …
In the last decade, advances in both oral and inhalation therapy have expanded the long-term control options available to these patie …
Pharmacologic management of supraventricular tachycardias in children. Part 2: Atrial flutter, atrial fibrillation, and junctional and atrial ectopic tachycardia.
Luedtke SA, Kuhn RJ, McCaffrey FM. Luedtke SA, et al. Among authors: kuhn rj. Ann Pharmacother. 1997 Nov;31(11):1347-59. doi: 10.1177/106002809703101113. Ann Pharmacother. 1997. PMID: 9391691 Review.
Although relatively unsuccessful in the management of congenital JET and AET, conventional agents are typically used prior to the initiation of long-term therapy with potentially more toxic agents such as amiodarone or propafenone. ...
Although relatively unsuccessful in the management of congenital JET and AET, conventional agents are typically used prior to the initiation …
Therapeutic management of cystic fibrosis.
Kuhn RJ, Nahata MC. Kuhn RJ, et al. Clin Pharm. 1985 Sep-Oct;4(5):555-65. Clin Pharm. 1985. PMID: 3931959 Review.
Aerosolized antibiotics have not been consistently useful in treating these patients, and there is no convincing evidence to support their long-term use. There are also no clear data to support the use of oral or aerosolized mucolytic agents. ...
Aerosolized antibiotics have not been consistently useful in treating these patients, and there is no convincing evidence to support their l …