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Trial watch: dexmedetomidine in cancer therapy.
Carnet Le Provost K, Kepp O, Kroemer G, Bezu L. Carnet Le Provost K, et al. Among authors: kroemer g. Oncoimmunology. 2024 Mar 11;13(1):2327143. doi: 10.1080/2162402X.2024.2327143. eCollection 2024. Oncoimmunology. 2024. PMID: 38481729 Free PMC article. Review.
Similarly, published clinical trials including ancillary studies described an immunostimulatory role of DEX during the perioperative period of cancer surgery. The impact of DEX on long-term patient survival remains elusive. Nevertheless, DEX-mediated immunostimulation offe …
Similarly, published clinical trials including ancillary studies described an immunostimulatory role of DEX during the perioperative period …
A guideline on the molecular ecosystem regulating ferroptosis.
Dai E, Chen X, Linkermann A, Jiang X, Kang R, Kagan VE, Bayir H, Yang WS, Garcia-Saez AJ, Ioannou MS, Janowitz T, Ran Q, Gu W, Gan B, Krysko DV, Zhu X, Wang J, Krautwald S, Toyokuni S, Xie Y, Greten FR, Yi Q, Schick J, Liu J, Gabrilovich DI, Liu J, Zeh HJ, Zhang DD, Yang M, Iovanna J, Kopf M, Adolph TE, Chi JT, Li C, Ichijo H, Karin M, Sankaran VG, Zou W, Galluzzi L, Bush AI, Li B, Melino G, Baehrecke EH, Lotze MT, Klionsky DJ, Stockwell BR, Kroemer G, Tang D. Dai E, et al. Among authors: kroemer g. Nat Cell Biol. 2024 Feb 29. doi: 10.1038/s41556-024-01360-8. Online ahead of print. Nat Cell Biol. 2024. PMID: 38424270 Review.
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mech …
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest …
Immunogenic cell stress and death in the treatment of cancer.
Pan H, Liu P, Zhao L, Pan Y, Mao M, Kroemer G, Kepp O. Pan H, et al. Among authors: kroemer g. Semin Cell Dev Biol. 2024 Mar 15;156:11-21. doi: 10.1016/j.semcdb.2023.10.007. Epub 2023 Nov 16. Semin Cell Dev Biol. 2024. PMID: 37977108 Review.
The successful treatment of oncological malignancies which results in long-term disease control or the complete eradication of cancerous cells necessitates the onset of adaptive immune responses targeting tumor-specific antigens. ...
The successful treatment of oncological malignancies which results in long-term disease control or the complete eradication of cancer …
From mucosal infection to successful cancer immunotherapy.
Goubet AG, Rouanne M, Derosa L, Kroemer G, Zitvogel L. Goubet AG, et al. Among authors: kroemer g. Nat Rev Urol. 2023 Nov;20(11):682-700. doi: 10.1038/s41585-023-00784-5. Epub 2023 Jul 11. Nat Rev Urol. 2023. PMID: 37433926 Review.
Moreover, growing evidence suggests that urinary or intestinal commensals, BCG and uropathogenic Escherichia coli influence long-term responses in patients with kidney or bladder cancer treated with ICBs. ...
Moreover, growing evidence suggests that urinary or intestinal commensals, BCG and uropathogenic Escherichia coli influence long-term …
Anticancer effects of ikarugamycin and astemizole identified in a screen for stimulators of cellular immune responses.
Zhang S, Zhao L, Guo M, Liu P, Li S, Xie W, Tian AL, Pol JG, Chen H, Pan H, Mao M, Li Y, Zitvogel L, Jin Y, Kepp O, Kroemer G. Zhang S, et al. Among authors: kroemer g. J Immunother Cancer. 2023 Jul;11(7):e006785. doi: 10.1136/jitc-2023-006785. J Immunother Cancer. 2023. PMID: 37419511 Free PMC article.
The combination of astemizole and oxaliplatin was able to cure the majority of mice bearing orthotopic non-small cell lung cancers (NSCLC), then inducing a state of protective long-term immune memory. The NSCLC-eradicating effect of astemizole plus oxaliplatin was lost on …
The combination of astemizole and oxaliplatin was able to cure the majority of mice bearing orthotopic non-small cell lung cancers (NSCLC), …
Assessment of immunological memory formation in vivo.
Zhang S, Zhao L, Chen H, Kroemer G, Liu P, Kepp O. Zhang S, et al. Among authors: kroemer g. Methods Cell Biol. 2023;174:65-73. doi: 10.1016/bs.mcb.2021.12.029. Epub 2022 Jan 17. Methods Cell Biol. 2023. PMID: 36710052
The reinstatement of cancer immunosurveillance during cancer therapy is the sole means of achieving long term success with durable disease control and sometimes even cure. ...
The reinstatement of cancer immunosurveillance during cancer therapy is the sole means of achieving long term success with durable di …
AIF Overexpression Aggravates Oxidative Stress in Neonatal Male Mice After Hypoxia-Ischemia Injury.
Li T, Sun Y, Zhang S, Xu Y, Li K, Xie C, Wang Y, Wang Y, Cao J, Wang X, Penninger JM, Kroemer G, Blomgren K, Zhu C. Li T, et al. Among authors: kroemer g. Mol Neurobiol. 2022 Nov;59(11):6613-6631. doi: 10.1007/s12035-022-02987-0. Epub 2022 Aug 17. Mol Neurobiol. 2022. PMID: 35974295 Free PMC article.
Under physiological conditions (without HI), the doublecortin-positive area in the dentate gyrus of females was 1.15 times larger than in males, indicating that AIF upregulation effectively promoted neurogenesis in females in the long term. We also found that AIF stimulate …
Under physiological conditions (without HI), the doublecortin-positive area in the dentate gyrus of females was 1.15 times larger than in ma …
Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer.
Terrisse S, Goubet AG, Ueda K, Thomas AM, Quiniou V, Thelemaque C, Dunsmore G, Clave E, Gamat-Huber M, Yonekura S, Ferrere G, Rauber C, Pham HP, Fahrner JE, Pizzato E, Ly P, Fidelle M, Mazzenga M, Costa Silva CA, Armanini F, Pinto F, Asnicar F, Daillère R, Derosa L, Richard C, Blanchard P, Routy B, Culine S, Opolon P, Silvin A, Ginhoux F, Toubert A, Segata N, McNeel DG, Fizazi K, Kroemer G, Zitvogel L. Terrisse S, et al. Among authors: kroemer g. J Immunother Cancer. 2022 Mar;10(3):e004191. doi: 10.1136/jitc-2021-004191. J Immunother Cancer. 2022. PMID: 35296557 Free PMC article.
Moreover, cohousing of PC-bearing mice with tumor-free mice or oral gavage with Akkermansia improved the efficacy of ADT. This appears to be applicable to PC patients because long-term ADT resulted in an increase of thymic output, as demonstrated by an increase in circulat …
Moreover, cohousing of PC-bearing mice with tumor-free mice or oral gavage with Akkermansia improved the efficacy of ADT. This appears to be …
Direct Cytotoxic and Indirect, Immune-Mediated Effects of Local Anesthetics Against Cancer.
Wu Chuang A, Kepp O, Kroemer G, Bezu L. Wu Chuang A, et al. Among authors: kroemer g. Front Oncol. 2022 Jan 14;11:821785. doi: 10.3389/fonc.2021.821785. eCollection 2021. Front Oncol. 2022. PMID: 35096626 Free PMC article. Review.
Retrospective studies have revealed an unexpected correlation between increased long-term survival and the use of local anesthetics during oncological surgery. ...
Retrospective studies have revealed an unexpected correlation between increased long-term survival and the use of local anesthetics d …
Autophagy in healthy aging and disease.
Aman Y, Schmauck-Medina T, Hansen M, Morimoto RI, Simon AK, Bjedov I, Palikaras K, Simonsen A, Johansen T, Tavernarakis N, Rubinsztein DC, Partridge L, Kroemer G, Labbadia J, Fang EF. Aman Y, et al. Among authors: kroemer g. Nat Aging. 2021 Aug;1(8):634-650. doi: 10.1038/s43587-021-00098-4. Epub 2021 Aug 12. Nat Aging. 2021. PMID: 34901876 Free PMC article. Review.
Understanding the precise interplay between autophagy and the risk of age-related pathologies across organisms will eventually facilitate the development of clinical applications that promote long-term health....
Understanding the precise interplay between autophagy and the risk of age-related pathologies across organisms will eventually facilitate th …
67 results