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Repression of the stress granule protein G3BP2 inhibits immune checkpoint molecule PD-L1.
Zhang Y, Yue C, Krichevsky AM, Garkavtsev I. Zhang Y, et al. Among authors: krichevsky am. Mol Oncol. 2021 Feb 1. doi: 10.1002/1878-0261.12915. Online ahead of print. Mol Oncol. 2021. PMID: 33525064 Free article.
Moreover, treatment of breast tumor-bearing mice with C108 resulted in a significant survival benefit and long-term cures. Cancer cells treated with C108 or cancer cells with genetically repressed G3BP2 had decreased PD-L1 expression due to enhanced mRNA degradation. ...
Moreover, treatment of breast tumor-bearing mice with C108 resulted in a significant survival benefit and long-term cures. Cancer cel …
Environmental enrichment prevents Aβ oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways.
Wei Z, Meng X, El Fatimy R, Sun B, Mai D, Zhang J, Arora R, Zeng A, Xu P, Qu S, Krichevsky AM, Selkoe DJ, Li S. Wei Z, et al. Among authors: krichevsky am. Neurobiol Dis. 2020 Feb;134:104617. doi: 10.1016/j.nbd.2019.104617. Epub 2019 Oct 24. Neurobiol Dis. 2020. PMID: 31669733 Free PMC article.
Here we confirm that exposing wild-type mice to an enriched environment (EE) facilitates signaling in the hippocampus that promotes long-term potentiation (LTP). Exposing the hippocampus of mice kept in standard housing to soluble Abeta oligomers impairs LTP, but EE can fu …
Here we confirm that exposing wild-type mice to an enriched environment (EE) facilitates signaling in the hippocampus that promotes long- …
Co-cultures of Glioma Stem Cells and Primary Neurons, Astrocytes, Microglia, and Endothelial Cells for Investigation of Intercellular Communication in the Brain.
Wei Z, Kale S, El Fatimy R, Rabinovsky R, Krichevsky AM. Wei Z, et al. Among authors: krichevsky am. Front Neurosci. 2019 Apr 18;13:361. doi: 10.3389/fnins.2019.00361. eCollection 2019. Front Neurosci. 2019. PMID: 31057356 Free PMC article.
Yet, distinct culture conditions for different neural cell types often make them incompatible for co-culturing. Here we optimized short-term co-cultures of patient-derived low-passage glioma-initiating stem cells with normal cells of the brain microenvironment, such as pri …
Yet, distinct culture conditions for different neural cell types often make them incompatible for co-culturing. Here we optimized short-t …
MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways.
El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM. El Fatimy R, et al. Among authors: krichevsky am. Acta Neuropathol. 2018 Oct;136(4):537-555. doi: 10.1007/s00401-018-1880-5. Epub 2018 Jul 7. Acta Neuropathol. 2018. PMID: 29982852 Free PMC article.
Similarly, miR-132 attenuates PHF-Tau pathology and neurodegeneration, and enhances long-term potentiation in the P301S Tau transgenic mice. The neuroprotective effects are mediated by direct regulation of the Tau modifiers acetyltransferase EP300, kinase GSK3beta, RNA-bin …
Similarly, miR-132 attenuates PHF-Tau pathology and neurodegeneration, and enhances long-term potentiation in the P301S Tau transgeni …