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Adler hantavirus, a new genetic variant of Tula virus identified in Major's pine voles (Microtus majori) sampled in southern European Russia.
Tkachenko EA, Witkowski PT, Radosa L, Dzagurova TK, Okulova NM, Yunicheva YV, Vasilenko L, Morozov VG, Malkin GA, Krüger DH, Klempa B. Tkachenko EA, et al. Among authors: kruger dh. Infect Genet Evol. 2015 Jan;29:156-63. doi: 10.1016/j.meegid.2014.11.018. Epub 2014 Nov 26. Infect Genet Evol. 2015. PMID: 25433134
High intra-cluster nucleotide sequence variability (up to 18%) and geographic clustering indicate long-term presence of the virus in this region....
High intra-cluster nucleotide sequence variability (up to 18%) and geographic clustering indicate long-term presence of the virus in …
Broad geographical distribution and high genetic diversity of shrew-borne Seewis hantavirus in Central Europe.
Schlegel M, Radosa L, Rosenfeld UM, Schmidt S, Triebenbacher C, Löhr PW, Fuchs D, Heroldová M, Jánová E, Stanko M, Mošanský L, Fričová J, Pejčoch M, Suchomel J, Purchart L, Groschup MH, Krüger DH, Klempa B, Ulrich RG. Schlegel M, et al. Among authors: kruger dh. Virus Genes. 2012 Aug;45(1):48-55. doi: 10.1007/s11262-012-0736-7. Epub 2012 Mar 31. Virus Genes. 2012. PMID: 22467179
The low intra-cluster sequence variability and the high inter-cluster divergence suggest a long-term SWSV evolution in isolated Sorex populations. In 28 of the 49 SWSV S-segment sequences, an additional putative open reading frame (ORF) on the opposite strand to the nucleo …
The low intra-cluster sequence variability and the high inter-cluster divergence suggest a long-term SWSV evolution in isolated Sorex …
Pyrosequencing allows the detection of emergent ganciclovir resistance mutations after HCMV infection.
Kampmann SE, Schindele B, Apelt L, Bührer C, Garten L, Weizsaecker K, Krüger DH, Ehlers B, Hofmann J. Kampmann SE, et al. Among authors: kruger dh. Med Microbiol Immunol. 2011 May;200(2):109-13. doi: 10.1007/s00430-010-0181-y. Epub 2010 Dec 17. Med Microbiol Immunol. 2011. PMID: 21165648
In a preterm baby born after 28 weeks of gestation and suffering from disseminated congenital HCMV infection, long-term control could not be achieved under ganciclovir/valganciclovir therapy and the infant died on the 113th day of life. ...
In a preterm baby born after 28 weeks of gestation and suffering from disseminated congenital HCMV infection, long-term control could …
High yields of stable and highly pure nucleocapsid proteins of different hantaviruses can be generated in the yeast Saccharomyces cerevisiae.
Razanskiene A, Schmidt J, Geldmacher A, Ritzi A, Niedrig M, Lundkvist A, Krüger DH, Meisel H, Sasnauskas K, Ulrich R. Razanskiene A, et al. Among authors: kruger dh. J Biotechnol. 2004 Aug 5;111(3):319-33. doi: 10.1016/j.jbiotec.2004.04.010. J Biotechnol. 2004. PMID: 15246668
The nucleocapsid proteins can be easily purified by nickel chelate chromatography; the yield for all nucleocapsid proteins ranged from 0.5 to 1.5 mg per g wet weight of yeast cells. In general, long-term storage of all nucleocapsid proteins without degradation can be obtai …
The nucleocapsid proteins can be easily purified by nickel chelate chromatography; the yield for all nucleocapsid proteins ranged from 0.5 t …
Proteasome inhibitors: a novel tool to suppress human cytomegalovirus replication and virus-induced immune modulation.
Prösch S, Priemer C, Höflich C, Liebenthaf C, Babel N, Krüger DH, Volk HD. Prösch S, et al. Among authors: kruger dh. Antivir Ther. 2003 Dec;8(6):555-67. Antivir Ther. 2003. PMID: 14760889
MG132 also reduced the immune modulatory activity of the virus by abrogating virus-induced up-regulation of cellular ICAM-1. These data suggest that short-term therapy with proteasome inhibitors might be an alternative strategy to prevent (re)activation, replication and im …
MG132 also reduced the immune modulatory activity of the virus by abrogating virus-induced up-regulation of cellular ICAM-1. These data sugg …
Complex HBV populations with mutations in core promoter, C gene, and pre-S region are associated with development of cirrhosis in long-term renal transplant recipients.
Preikschat P, Günther S, Reinhold S, Will H, Budde K, Neumayer HH, Krüger DH, Meisel H. Preikschat P, et al. Among authors: kruger dh. Hepatology. 2002 Feb;35(2):466-77. doi: 10.1053/jhep.2002.30698. Hepatology. 2002. PMID: 11826424
Long-term immunosuppressed renal transplant recipients with chronic hepatitis B virus (HBV) infection often develop liver cirrhosis (LC) and end-stage liver disease (ESLD). ...In conclusion, these data suggest that accumulation and persistence of specific HBV populations c …
Long-term immunosuppressed renal transplant recipients with chronic hepatitis B virus (HBV) infection often develop liver cirrhosis ( …
Pentoxifylline promotes replication of human cytomegalovirus in vivo and in vitro.
Staak K, Prosch S, Stein J, Priemer C, Ewert R, Docke WD, Kruger DH, Volk HD, Reinke P. Staak K, et al. Among authors: kruger dh. Blood. 1997 May 15;89(10):3682-90. Blood. 1997. PMID: 9160673 Free article.
Unfortunately, this therapy is associated with several short-term (cytokine release syndrome) and long-term (infections, EBV-related lymphoma) side effects. ...
Unfortunately, this therapy is associated with several short-term (cytokine release syndrome) and long-term (infections, EBV-r …
Accumulation and persistence of hepatitis B virus core gene deletion mutants in renal transplant patients are associated with end-stage liver disease.
Günther S, Baginski S, Kissel H, Reinke P, Krüger DH, Will H, Meisel H. Günther S, et al. Among authors: kruger dh. Hepatology. 1996 Oct;24(4):751-8. doi: 10.1002/hep.510240401. Hepatology. 1996. PMID: 8855172
These results indicate that HBV C-gene deletion mutants can accumulate in long-term immunosuppressed patients, and that their persistence is associated with progressive liver disease. ...
These results indicate that HBV C-gene deletion mutants can accumulate in long-term immunosuppressed patients, and that their persist …