Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.
Drube S, Weber F, Loschinski R, Beyer M, Rothe M, Rabenhorst A, Göpfert C, Meininger I, Diamanti MA, Stegner D, Häfner N, Böttcher M, Reinecke K, Herdegen T, Greten FR, Nieswandt B, Hartmann K, Krämer OH, Kamradt T.
Drube S, et al. Among authors: kramer oh.
Oncotarget. 2015 Mar 10;6(7):5354-68. doi: 10.18632/oncotarget.3022.
Oncotarget. 2015.
PMID: 25749030
Free PMC article.
We show here that IL-3 induces a SFK- and Ca2+-dependent activation of the inhibitor of kappaB kinases 2 (IKK2) which results in mast cell proliferation and survival but does not induce IkappaBalpha-degradation and NFkappaB activation. Therefore we propose the term "subthr …
We show here that IL-3 induces a SFK- and Ca2+-dependent activation of the inhibitor of kappaB kinases 2 (IKK2) which results in mast cell p …