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NOXA Accentuates Apoptosis Induction by a Novel Histone Deacetylase Inhibitor.
Ashry R, Mustafa AM, Hausmann K, Linnebacher M, Strand S, Sippl W, Wirth M, Krämer OH. Ashry R, et al. Among authors: kramer oh. Cancers (Basel). 2023 Jul 17;15(14):3650. doi: 10.3390/cancers15143650. Cancers (Basel). 2023. PMID: 37509312 Free PMC article.
We evaluated a novel hydroxamic acid-based HDACi (KH16; termed yanostat) in human pancreatic ductal adenocarcinoma (PDAC) cells, short- and long-term cultured colorectal cancer (CRC) cells, and retinal pigment epithelial cells. ...
We evaluated a novel hydroxamic acid-based HDACi (KH16; termed yanostat) in human pancreatic ductal adenocarcinoma (PDAC) cells, short- and …
Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress.
Marx C, Sonnemann J, Maddocks ODK, Marx-Blümel L, Beyer M, Hoelzer D, Thierbach R, Maletzki C, Linnebacher M, Heinzel T, Krämer OH. Marx C, et al. Among authors: kramer oh. Cancer Metab. 2022 Jul 4;10(1):10. doi: 10.1186/s40170-022-00286-9. Cancer Metab. 2022. PMID: 35787728 Free PMC article.
METHODS: We incubated p53-positive and p53-negative permanent CRC cells and short-term cultured primary CRC cells with the topoisomerase-1 inhibitor irinotecan and other drugs that cause DNA replication stress and consequently DNA damage. ...
METHODS: We incubated p53-positive and p53-negative permanent CRC cells and short-term cultured primary CRC cells with the topoisomer …
The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracil.
Kiweler N, Schwarz H, Nguyen A, Matschos S, Mullins C, Piée-Staffa A, Brachetti C, Roos WP, Schneider G, Linnebacher M, Brenner W, Krämer OH. Kiweler N, et al. Among authors: kramer oh. Cell Biol Toxicol. 2023 Oct;39(5):2401-2419. doi: 10.1007/s10565-022-09731-3. Epub 2022 May 24. Cell Biol Toxicol. 2023. PMID: 35608750 Free PMC article.
MSI promotes a genetic frameshift and consequently a loss of HDAC2 in up to 43% of these tumors. We show that long-term and short-term cultures of colorectal cancers with MSI contain subpopulations of cells lacking HDAC2. ...
MSI promotes a genetic frameshift and consequently a loss of HDAC2 in up to 43% of these tumors. We show that long-term and short- …
Class 1 Histone Deacetylases and Ataxia-Telangiectasia Mutated Kinase Control the Survival of Murine Pancreatic Cancer Cells upon dNTP Depletion.
Nguyen A, Dzulko M, Murr J, Yen Y, Schneider G, Krämer OH. Nguyen A, et al. Among authors: kramer oh. Cells. 2021 Sep 23;10(10):2520. doi: 10.3390/cells10102520. Cells. 2021. PMID: 34685500 Free PMC article.
Here, we show how an inhibition of de novo dNTP synthesis by the ribonucleotide reductase (RNR) inhibitor hydroxyurea and an inhibition of epigenetic modifiers of the histone deacetylase (HDAC) family affect short-term cultured primary murine PDAC cells. We used clinically …
Here, we show how an inhibition of de novo dNTP synthesis by the ribonucleotide reductase (RNR) inhibitor hydroxyurea and an inhibition of e …
Establishment and characterization of HROC69 - a Crohn´s related colonic carcinoma cell line and its matched patient-derived xenograft.
Kuehn F, Mullins CS, Krohn M, Harnack C, Ramer R, Krämer OH, Klar E, Huehns M, Linnebacher M. Kuehn F, et al. Among authors: kramer oh. Sci Rep. 2016 Apr 18;6:24671. doi: 10.1038/srep24671. Sci Rep. 2016. PMID: 27087592 Free PMC article.
We first describe the clinical case of a fast growing CAC in a long-term immunosuppressed patient with Crohns disease and successful establishment and characterization of carcinoma cell lines along with their corresponding patient-derived xenograft. ...
We first describe the clinical case of a fast growing CAC in a long-term immunosuppressed patient with Crohns disease and successful …
Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.
Drube S, Weber F, Loschinski R, Beyer M, Rothe M, Rabenhorst A, Göpfert C, Meininger I, Diamanti MA, Stegner D, Häfner N, Böttcher M, Reinecke K, Herdegen T, Greten FR, Nieswandt B, Hartmann K, Krämer OH, Kamradt T. Drube S, et al. Among authors: kramer oh. Oncotarget. 2015 Mar 10;6(7):5354-68. doi: 10.18632/oncotarget.3022. Oncotarget. 2015. PMID: 25749030 Free PMC article.
We show here that IL-3 induces a SFK- and Ca2+-dependent activation of the inhibitor of kappaB kinases 2 (IKK2) which results in mast cell proliferation and survival but does not induce IkappaBalpha-degradation and NFkappaB activation. Therefore we propose the term "subthr …
We show here that IL-3 induces a SFK- and Ca2+-dependent activation of the inhibitor of kappaB kinases 2 (IKK2) which results in mast cell p …
Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.
Romanski A, Schwarz K, Keller M, Wietbrauk S, Vogel A, Roos J, Oancea C, Brill B, Krämer OH, Serve H, Ruthardt M, Bug G. Romanski A, et al. Among authors: kramer oh. Cell Cycle. 2012 Sep 1;11(17):3219-26. doi: 10.4161/cc.21565. Epub 2012 Aug 16. Cell Cycle. 2012. PMID: 22895185 Free PMC article.
The aim of the study was to investigate the effects of DACi on leukemic stem and progenitor cells using murine transduction-transplantation models of hematopoietic cells harboring the leukemia-associated fusion proteins (LAFP) PLZF/RARalpha or a truncated AML1/ETO protein (AML1/E …
The aim of the study was to investigate the effects of DACi on leukemic stem and progenitor cells using murine transduction-transplantation …
A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer.
Stauber RH, Knauer SK, Habtemichael N, Bier C, Unruhe B, Weisheit S, Spange S, Nonnenmacher F, Fetz V, Ginter T, Reichardt S, Liebmann C, Schneider G, Krämer OH. Stauber RH, et al. Among authors: kramer oh. Oncotarget. 2012 Jan;3(1):31-43. doi: 10.18632/oncotarget.430. Oncotarget. 2012. PMID: 22289787 Free PMC article.
As inherent and acquired resistance to therapy counteracts improvement of long-term survival, novel multi-targeting strategies triggering cancer cell death are urgently required. ...
As inherent and acquired resistance to therapy counteracts improvement of long-term survival, novel multi-targeting strategies trigge …