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Long-Term Survivors after Failure of Chimeric Antigen Receptor T Cell Therapy for Large B Cell Lymphoma: A Role for Allogeneic Hematopoietic Cell Transplantation? A German Lymphoma Alliance and German Registry for Stem Cell Transplantation Analysis.
Derigs P, Bethge WA, Krämer I, Holtick U, von Tresckow B, Ayuk F, Penack O, Vucinic V, von Bonin M, Baldus C, Mougiakakos D, Wulf G, Schnetzke U, Stelljes M, Fante M, Schroers R, Kroeger N, Dreger P; German Lymphoma Alliance and the German Registry for Stem Cell Transplantation. Derigs P, et al. Among authors: kramer i. Transplant Cell Ther. 2023 Dec;29(12):750-756. doi: 10.1016/j.jtct.2023.09.008. Epub 2023 Sep 13. Transplant Cell Ther. 2023. PMID: 37709204
The purpose of this study was to investigate characteristics, relapse patterns, and management strategies in long-term survivors after CAR-T failure, with a particular focus on the feasibility and outcome of alloHCT. ...AlloHCT after CAR-T failure in LBCL is feasible and m …
The purpose of this study was to investigate characteristics, relapse patterns, and management strategies in long-term survivors afte …
Glucocorticoids in Graves' orbitopathy: mechanisms of action and clinical application.
Längericht J, Krämer I, Kahaly GJ. Längericht J, et al. Among authors: kramer i. Ther Adv Endocrinol Metab. 2020 Dec 14;11:2042018820958335. doi: 10.1177/2042018820958335. eCollection 2020. Ther Adv Endocrinol Metab. 2020. PMID: 33403097 Free PMC article. Review.
Fast and significant improvements in orbital symptoms and signs are noted in 65-70% of patients. Long-term experience over decades, and worldwide availability at low cost, underline the clinical and therapeutic relevance of GC. ...Innovative biologicals, like monoclonal an …
Fast and significant improvements in orbital symptoms and signs are noted in 65-70% of patients. Long-term experience over decades, a …
Cortical bone adaptation to a moderate level of mechanical loading in male Sost deficient mice.
Yang H, Büttner A, Albiol L, Julien C, Thiele T, Figge C, Kramer I, Kneissel M, Duda GN, Checa S, Willie BM. Yang H, et al. Among authors: kramer i. Sci Rep. 2020 Dec 18;10(1):22299. doi: 10.1038/s41598-020-79098-0. Sci Rep. 2020. PMID: 33339872 Free PMC article.
A decrease in the Wnt inhibitor Dkk1 expression was observed 3 h after loading in 52-week-old Sost KO and LC mice, and an increase in Lef1 expression was observed 8 h after loading in 10-week-old Sost KO mice. The current results suggest that long-term inhibition of sclero …
A decrease in the Wnt inhibitor Dkk1 expression was observed 3 h after loading in 52-week-old Sost KO and LC mice, and an increase in Lef1 e …
Sost deficiency leads to reduced mechanical strains at the tibia midshaft in strain-matched in vivo loading experiments in mice.
Albiol L, Cilla M, Pflanz D, Kramer I, Kneissel M, Duda GN, Willie BM, Checa S. Albiol L, et al. Among authors: kramer i. J R Soc Interface. 2018 Apr;15(141):20180012. doi: 10.1098/rsif.2018.0012. J R Soc Interface. 2018. PMID: 29669893 Free PMC article.
Sost knockout (KO) mice were examined to gain insight into how long-term Sost deficiency alters the local mechanical environment within the bone. ...
Sost knockout (KO) mice were examined to gain insight into how long-term Sost deficiency alters the local mechanical environment with …
Effects of momentary self-monitoring on empowerment in a randomized controlled trial in patients with depression.
Simons CJ, Hartmann JA, Kramer I, Menne-Lothmann C, Höhn P, van Bemmel AL, Myin-Germeys I, Delespaul P, van Os J, Wichers M. Simons CJ, et al. Among authors: kramer i. Eur Psychiatry. 2015 Nov;30(8):900-6. doi: 10.1016/j.eurpsy.2015.09.004. Epub 2015 Oct 6. Eur Psychiatry. 2015. PMID: 26647864 Clinical Trial.
CONCLUSIONS: These findings tentatively suggest that self-monitoring to complement standard antidepressant treatment may increase patients' feelings of empowerment. Further research is necessary to investigate long-term empowering effects of self-monitoring in combination …
CONCLUSIONS: These findings tentatively suggest that self-monitoring to complement standard antidepressant treatment may increase patients' …
Mechanical load increases in bone formation via a sclerostin-independent pathway.
Morse A, McDonald MM, Kelly NH, Melville KM, Schindeler A, Kramer I, Kneissel M, van der Meulen MC, Little DG. Morse A, et al. Among authors: kramer i. J Bone Miner Res. 2014 Nov;29(11):2456-67. doi: 10.1002/jbmr.2278. J Bone Miner Res. 2014. PMID: 24821585 Free PMC article.
Sclerostin, encoded by the Sost gene, is an important negative regulator of bone formation that has been proposed to have a key role in regulating the response to mechanical loading. To investigate the effect of long-term Sclerostin deficiency on mechanotransduction in bon …
Sclerostin, encoded by the Sost gene, is an important negative regulator of bone formation that has been proposed to have a key role in regu …
Increased medication compliance of liver transplant patients switched from a twice-daily to a once-daily tacrolimus-based immunosuppressive regimen.
Eberlin M, Otto G, Krämer I. Eberlin M, et al. Among authors: kramer i. Transplant Proc. 2013 Jul-Aug;45(6):2314-20. doi: 10.1016/j.transproceed.2012.10.037. Epub 2013 May 29. Transplant Proc. 2013. PMID: 23726723
BACKGROUND: Compliance with immunosuppressive therapy plays a major role in the long-term success of liver transplantation. Thus, the development of strategies to promote compliance of liver transplant patients and its evaluation over time are of particular interest. ...
BACKGROUND: Compliance with immunosuppressive therapy plays a major role in the long-term success of liver transplantation. Thus, the …
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