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University of Pennsylvania Lung Transplantation: update 2012.
Lee JC, Blumenthal NP, Kotloff RM, Cantu E, Ahya VN; University of Pennsylvania Lung Transplant Program. Lee JC, et al. Among authors: kotloff rm. Clin Transpl. 2012:145-54. Clin Transpl. 2012. PMID: 23721017 Free PMC article.
We aim to continue to be leaders in the field of transplant related research, with goals of improving short- and long-term outcomes and safely allowing this procedure to be made available to more patients who need it. ...
We aim to continue to be leaders in the field of transplant related research, with goals of improving short- and long-term outcomes a …
Lung transplantation.
Kotloff RM, Thabut G. Kotloff RM, et al. Am J Respir Crit Care Med. 2011 Jul 15;184(2):159-71. doi: 10.1164/rccm.201101-0134CI. Epub 2011 Mar 31. Am J Respir Crit Care Med. 2011. PMID: 21471083 Review.
Post-transplantation survival has steadily improved, but significant constraints on long-term survival persist as evidenced by a median survival rate that currently stands at 5.7 years. ...Primary graft dysfunction, infection, and bronchiolitis obliterans syndrome are comm …
Post-transplantation survival has steadily improved, but significant constraints on long-term survival persist as evidenced by a medi …
Lung transplantation for chronic obstructive pulmonary disease: special considerations.
Diamond J, Kotloff RM. Diamond J, et al. Among authors: kotloff rm. Semin Respir Crit Care Med. 2010 Apr;31(2):115-22. doi: 10.1055/s-0030-1249108. Epub 2010 Mar 30. Semin Respir Crit Care Med. 2010. PMID: 20354925
Since the introduction of lung transplantation nearly half a century ago, more procedures have been performed for chronic obstructive pulmonary disease (COPD) than for any other single indication. Because COPD tends to progress slowly and long-term survival is possible eve …
Since the introduction of lung transplantation nearly half a century ago, more procedures have been performed for chronic obstructive pulmon …
Does lung transplantation confer a survival benefit?
Kotloff RM. Kotloff RM. Curr Opin Organ Transplant. 2009 Oct;14(5):499-503. doi: 10.1097/MOT.0b013e32832fb9f8. Curr Opin Organ Transplant. 2009. PMID: 19617824 Review.
Demonstration of a survival benefit has been more problematic, largely due to significant constraints on long-term survival. This article reviews the current literature addressing the question of whether transplantation is truly a life-extending procedure. ...
Demonstration of a survival benefit has been more problematic, largely due to significant constraints on long-term survival. This art …
Selection of candidates for lung transplantation.
Kreider M, Kotloff RM. Kreider M, et al. Among authors: kotloff rm. Proc Am Thorac Soc. 2009 Jan 15;6(1):20-7. doi: 10.1513/pats.200808-097GO. Proc Am Thorac Soc. 2009. PMID: 19131527 Review.
Finally, selection is influenced by the particular metric by which outcomes are judged to be successful (e.g., maximizing short-term net survival benefit versus maximizing post-transplant longevity). ...
Finally, selection is influenced by the particular metric by which outcomes are judged to be successful (e.g., maximizing short-term …
Renal and vestibular toxicity due to inhaled tobramycin in a lung transplant recipient.
Ahya VN, Doyle AM, Mendez JD, Lipson DA, Christie JD, Blumberg EA, Pochettino A, Nelson L, Bloom RD, Kotloff RM. Ahya VN, et al. Among authors: kotloff rm. J Heart Lung Transplant. 2005 Jul;24(7):932-5. doi: 10.1016/j.healun.2004.05.008. J Heart Lung Transplant. 2005. PMID: 15982625
Chronic rejection is the major hurdle to long-term survival after lung transplantation. Endobronchial infection with Pseudomonas aeruginosa is common in patients with chronic rejection and this may further contribute to deterioration of the allograft. ...
Chronic rejection is the major hurdle to long-term survival after lung transplantation. Endobronchial infection with Pseudomonas aeru …
The effect of primary graft dysfunction on survival after lung transplantation.
Christie JD, Kotloff RM, Ahya VN, Tino G, Pochettino A, Gaughan C, DeMissie E, Kimmel SE. Christie JD, et al. Among authors: kotloff rm. Am J Respir Crit Care Med. 2005 Jun 1;171(11):1312-6. doi: 10.1164/rccm.200409-1243OC. Epub 2005 Mar 11. Am J Respir Crit Care Med. 2005. PMID: 15764726 Free PMC article.
RATIONALE: Primary graft dysfunction is a severe acute lung injury syndrome after lung transplantation. Long-term outcomes of subjects with primary graft dysfunction have not been studied. ...CONCLUSION: Primary graft dysfunction contributes to nearly half of the short- …
RATIONALE: Primary graft dysfunction is a severe acute lung injury syndrome after lung transplantation. Long-term outcomes of subject …
Pulmonary complications of solid organ and hematopoietic stem cell transplantation.
Kotloff RM, Ahya VN, Crawford SW. Kotloff RM, et al. Am J Respir Crit Care Med. 2004 Jul 1;170(1):22-48. doi: 10.1164/rccm.200309-1322SO. Epub 2004 Apr 7. Am J Respir Crit Care Med. 2004. PMID: 15070821 Review.
Although advances in surgical techniques, immunosuppressive management, and prophylaxis and treatment of infectious diseases have made long-term survival an achievable goal, transplant recipients remain at high risk for developing a myriad of serious and often life-threate …
Although advances in surgical techniques, immunosuppressive management, and prophylaxis and treatment of infectious diseases have made long- …
Medical complications of lung transplantation.
Kotloff RM, Ahya VN. Kotloff RM, et al. Eur Respir J. 2004 Feb;23(2):334-42. doi: 10.1183/09031936.03.00043403. Eur Respir J. 2004. PMID: 14979513 Free article. Review.
Surgical advances, in conjunction with more effective immunosuppressive strategies, have propelled the field of lung transplantation forward and have made intermediate-term survival an achievable goal. Nonetheless, the post-transplant course is often marked by complication …
Surgical advances, in conjunction with more effective immunosuppressive strategies, have propelled the field of lung transplantation forward …
Apical perfusion fraction as a predictor of short-term functional outcome following bilateral lung volume reduction surgery.
Kotloff RM, Hansen-Flaschen J, Lipson DA, Tino G, Arcasoy SM, Alavi A, Kaiser LR. Kotloff RM, et al. Chest. 2001 Nov;120(5):1609-15. doi: 10.1378/chest.120.5.1609. Chest. 2001. PMID: 11713142
CONCLUSION: This retrospective analysis suggests that quantification of apical perfusion by nuclear scintigraphy assists in predicting the likelihood of short-term functional improvement after LVRS....
CONCLUSION: This retrospective analysis suggests that quantification of apical perfusion by nuclear scintigraphy assists in predicting the l …
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